Comparison of Therapeutic Outcomes Between Surgical Resection Followed By R-CHOP and R-CHOP Alone for Localized Primary Intestinal Diffuse Large B-cell Lymphoma

Lee, Ho Sup; Park, Lee Chun; Lee, Eun Mi; Shin, Seong Hoon; Ye, Byeong Jin; Oh, Sung Yong; Song, Moo-Kon; Lee, Sang Min; Lee, Won Sik; Kang, Byung Woog; Chang, Myung Hee; Cho, Seok Goo; Yahng, Seung Ah; Yoon, Sung‐Soo; Kwon, Jihoon; Kim, Yang Soo

doi:10.1097/coc.0b013e318271b125

Cited by 25 publications

(22 citation statements)

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“…Resection in addition to chemotherapy increases survival over chemotherapy alone for patients with intestinal diffuse large B-cell lymphoma. 45 In a recent retrospective cohort study, 2-yr OS for patients undergoing complete resection of intra-abdominal follicular lymphoma was similar to those treated with chemotherapy. 46 For PCNSL, available chemotherapeutic regimens are not as effective as those for systemic lymphoma.…”

Section: Discussionmentioning

confidence: 90%

Craniotomy and Survival for Primary Central Nervous System Lymphoma

Rae

Mehta

Cloney³

et al. 2018

Neurosurg.

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Section: Discussionmentioning

confidence: 90%

Craniotomy and Survival for Primary Central Nervous System Lymphoma

Rae

Mehta

Cloney³

et al. 2018

Neurosurg.

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“…A growing body of evidence demonstrates the potential for improved outcomes and survival in certain systemic lymphomas with surgical resection. For example, in patients with intestinal diffuse large B-cell lymphoma, those treated with surgical resection followed by chemotherapy had improved progression-free and overall survival versus chemotherapy alone [15]. Also, the surgical treatment for pediatric intra-abdominal lymphomas is typically limited to diagnostic laparotomies and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Primary Central Nervous System Lymphoma: A Critical Review of the Role of Surgery for Resection

2016

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Background Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that carry a poor prognosis, with most patients suffering recurrence. Progress has been made in the treatment of this pathology, notably with the widespread use of systemic high dose methotrexate. However, unlike most other malignant CNS neoplasms, surgery for cytoreduction is not routinely performed for this disease, mainly as a result of negative experiences decades ago. Since these studies were published, the availability of intraoperative monitoring, MR imaging and neuro-navigation as well as surgical adjuncts such as fluorescence- guided resection have greatly improved the safety of intracranial procedures. More recent data is suggestive of a potential survival benefit for resection of single PCNSL lesions when patients are subsequently treated with modern regimen high-dose methotrexate, yet this evidence is limited, and should be interpreted conservatively. Methods and findings A systematic review of the literature was performed to identify trials evaluating surgical options for the treatment of PCNSL. Conclusion In this review, we provide a critical overview of the evidence favoring and discouraging resection for PCNSL. This literature suffers from several biases and limitations that must be considered in the context of the extrapolation of this literature into clinical decision-making.

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“…Several studies have shown a survival benefit for surgery and chemotherapy/radiation therapy compared to chemotherapy and/or radiation therapy alone . The largest of these trials was a retrospective study of 345 patients with GI DLBCL .…”

Section: Discussionmentioning

confidence: 99%

“…15 Several studies have shown a survival benefit for surgery and chemotherapy/radiation therapy compared to chemotherapy and/or radiation therapy alone. [16][17][18][19][20][21] The largest of these trials was a retrospective study of 345 patients with GI DLBCL. 16 The study revealed that patients with Lugano stage I/II GI DLBCL who underwent resection followed by chemotherapy with CHOP or R-CHOP had a lower relapse rate compared to those who received chemotherapy alone (15.3% vs 36.8%, P < .001).…”

Section: Discussionmentioning

confidence: 99%