Comparison of the СT patterns and pulmonary histology in patients with COVID-19

Першина, Е. С.; Черняев, А. Л.; Самсонова, М. В.; Варясин, В. В.; Omarova, Zh.R.; Перешивайлов, С. О.; Бережная, Елена Эдуардовна; Parshin, V. V.; Михайличенко, К. Ю.; Shilova, Alexandra; Щекочихин, Д. Ю.; Гиляров, М. Ю.

doi:10.24835/1607-0763-2020-3-37-53

Cited by 7 publications

(2 citation statements)

References 16 publications

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“…According to Feng Pan and co-authors, the areas of GGO were caused by intra-alveolar edema or protein exudate, but according to Pershina et al [47], an increase in the number of cells, hyaline membranes, and desquamation of the alveolar epithelium was detected in the lumen of the alveoli at autopsy of more seriously ill patients. In any case, both types of changes lead to a decrease in the area of the functional surface of the lung involved in gas exchange.…”

Section: Discussionmentioning

confidence: 99%

Differences in Dynamics of Lung Computed Tomography Patterns between Survivors and Deceased Adult Patients with COVID-19

et al. 2021

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This study’s aim was to investigate CT (computed tomography) pattern dynamics differences within surviving and deceased adult patients with COVID-19, revealing new prognostic factors and reproducing already known data with our patients’ cohort: 635 hospitalized patients (55.3% of them were men, 44.7%—women), of which 87.3% had a positive result of RT-PCR (reverse transcription-polymerase chain reaction) at admission. The number of deaths was 53 people (69.8% of them were men and 30.2% were women). In total, more than 1500 CT examinations were performed on patients, using a GE Optima CT 660 computed tomography (General Electric Healthcare, USA). The study was performed at hospital admission, the frequency of repetitive scans further varied based on clinical need. The interpretation of the imaging data was carried out by 11 radiologists with filling in individual registration cards that take into account the scale of the lesion, the location, contours, and shape of the foci, the dominating types of changes, as well as the presence of additional findings and the dynamics of the process—a total of 45 parameters. Statistical analysis was performed using the software packages SPSS Statistics version 23.0 (IBM, Armonk, NY, USA) and R software version 3.3.2. For comparisons in pattern dynamics across hospitalization we used repeated measures general linear model with outcome and disease phase as factors. The crazy paving pattern, which is more common and has a greater contribution to the overall CT picture in different phases of the disease in deceased patients, has isolated prognostic significance and is probably a reflection of faster dynamics of the process with a long phase of progression of pulmonary parenchyma damage with an identical trend of changes in the scale of the lesion (as recovered) in this group of patients. Already known data on typical pulmonological CT manifestations of infection, frequency of occurrence, and the prognostic significance of the scale of the lesion were reproduced, new differences in the dynamics of the process between recovered and deceased adult patients were also found that may have prognostic significance and can be reflected in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Differences in Dynamics of Lung Computed Tomography Patterns between Survivors and Deceased Adult Patients with COVID-19

et al. 2021

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“…В настоящее время краткосрочные результаты компьютерной томографии (КТ) после перенесенной новой коронавирусной инфекции в значительной степени описаны [5][6][7][8]. Известно, что при выписке из отделения реанимации и интенсивной терапии (ОРИТ) у 94% пациентов сохраняются изменения в паренхиме легких, преимущественно в виде остаточного «матового стекла».…”

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Long-term effects of COVID-19 in patients according to the functional lung imaging in radiation therapy

Zolotnitskaya¹,

Speranskaya²,

Kuzubova³

et al. 2022

Russian Medical Inquiry

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Background: the majority of patients who experienced COVID-19, lung disorders persist for a long term. It remains unclear how reversible they are and what the clinical and radiation predictors of these changes are. Aim: to determine the consequences of pneumonia caused by the SARS-CoV-2 virus in patients who experienced COVID-19 during the period of 2020–2021; to evaluate possible clinical and radiation predictors of these changes and their reversibility. Patients and Methods: the article presents the analyzed results of radiation studies (computed tomography (CT), single-photon emission computed tomography (SPECT)), spirometry and diffusing capacity of the lungs for carbon monoxide (DLCO) performed in 68 patients who had COVID-19 during the period of 2020–2021 and complained of persistent shortness of breath, fatigue and disability. Results: 1–2 years after, there was a decrease in the bronchial patency to 39.2±4.5%pred in 63% of patients with mild COVID-19, which correlated (rs>0.92) with a decrease in microcirculation (MC) over 50% and mosaic attenuation (rs>0.77), air trapping (rs>0.89) and bronchiolectasis (rs>0.64). In mixed ventilatory defects (MEF75 to 46.8±3.6% of predicted, DLCO 62.4±3.1% of predicted), there were significant MC disorders over 70%, corresponding to zones of focal pneumosclerosis (rs>0.93). In the severe disease course, single areas of "frosted glass" were detected in 13% of patients, while mosaic attenuation and air trapping were detected in 34%, which was accompanied by a decrease in MEF75 to 37.4±3.7% of predicted. During a decrease in DLCO to 52.4±2.2% of predicted, there were a compaction of the interstitial by the type of usual interstitial pneumonia of small extent (65%), consolidation areas (34%), pneumosclerosis areas (54%), platelike atelectasis (31%), bronchiectasis (26%), signs of bronchiolitis obliterans (42%), and pulmonary hypertension development (38%). According to the single- photon emission computed tomography data, there were significant disorders of the MC. Irreversible changes were detected in lung areas with an inadequate perfusion of more than 50%, observed 6 months after the disease, and subsequently, after 1 year or more. Conclusions: a comprehensive functional lung imaging in radiation therapy increases the efficacy of clinical examination of patients in the postcovid period. The following type of patients need a comprehensive radiation monitoring: patients over 60 y.o., patients who had a severe COVID-19; patients who have respiratory complaints over 1 year, regardless of the COVID-19 severity. Microcirculation disorders over 50% detected 6 months after the disease are a predictor of changes in the lung parenchyma and may indicate long-term disease consequences. KEYWORDS: postcovid syndrome, microcirculation, computed tomography of the lungs, ventilation, artificial intelligence. FOR CITATION: Zolotnitskaya V.P., Speranskaya A.A., Kuzubova N.A. et al. Long-term effects of COVID-19 in patients according to the functional lung imaging in radiation therapy. Russian Medical Inquiry. 2022;6(7):360–366 (in Russ.). DOI: 10.32364/2587-6821- 2022-6-7-360-366.

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The achievements of pulmonology and the main directions of further improvement of medical care in the Russian Federation

Биличенко

Shutov

2021

Pulʹmonologiâ (Mosk.)

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The development of pulmonology in Russia is linked with the creative activity of the Scientific Research Institute of Pulmonology of the Federal Medico-Biological Agency (Research Institute of Pulmonology of the FMBA) and its scientific school.The aim of the analytical review was to assess the role and contribution of the research team of the Research Institute of Pulmonology in improving the quality of medical care to the population of Russia.Methods. The data of medical statistics of the Ministry of Health of the Russian Federation on morbidity and mortality of the population due to respiratory diseases (RD) from 2004 - 2018 are analyzed. The publications on scientific research conducted with the participation of employees of the Research Institute of Pulmonology for the period from 2005 to 2020 were studied.Results. Over the past 30 years in Russia, with the participation of the staff of the Research Institute of Pulmonology, the state task of creating a system for organizing medical care for the population with RD has been successfully solved. The study and implementation of modern innovative approaches in the diagnosis, treatment and prevention of RD, the training of primary care physicians allowed to improve the quality of medical care to patients to the level of world standards. For the period from 2004 - 2018 the mortality of the population from RD 35.6% decrease was registered. During the pandemic of a new coronavirus infection, the use of pulmonology achievements in clinical practice contributed to a decrease in the frequency of deaths in people with COVID-19.Conclusion. Currently, the Research Institute of Pulmonology of the FMBA of Russia retains a leading position in the country in the field of fundamental scientific research, innovative methods of diagnosis and treatment of RD, educational activities and training of specialists in the field of pulmonology.

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Comparison of the СT patterns and pulmonary histology in patients with COVID-19

Cited by 7 publications

References 16 publications

Differences in Dynamics of Lung Computed Tomography Patterns between Survivors and Deceased Adult Patients with COVID-19

Differences in Dynamics of Lung Computed Tomography Patterns between Survivors and Deceased Adult Patients with COVID-19

Long-term effects of COVID-19 in patients according to the functional lung imaging in radiation therapy

The achievements of pulmonology and the main directions of further improvement of medical care in the Russian Federation

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