Comparison of the Vβ Repertoire in Peripheral Blood and in Lymph Nodes of HIV-Infected Subjects Reveals Skewed Usage Predominantly in CD8+T Cells

Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody responses and rapid progression.

“…Some of the earliest studies on HIV infection documented the ability of virus antigens to stimulate polyclonal activation of peripheral blood B cells (Schnittman et al, 1986). More recently, bystander killing of B cells in HIV-positive lymph nodes was reported to proceed by an apoptotic mechanism (Carbonari et al, 1997). Our studies of acute SHIV infection in macaques showed apoptotic death of B cells in parallel with CD4 + T cell depletion (M. Wallace & C. D. Pauza, unpublished).…”

Oligoclonal T cells are infiltrating the brains of children with AIDS: sequence analysis reveals high proportions of identical β-chain T-cell receptor transcripts

“…In spleen white pulps HIV‐1‐specific T cells are highly compartmentalized [107]. In lymph nodes [108] and lungs [109] certain Vβ families were overrepresented in CD8+ T cells. T cells in labial salivary glands in patients with the sicca syndrome of HIV‐1 preferentially utilized Jβ1·2 [110].…”

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection

“…One possible explanation for the slightly stronger correlation in HIV-1 infection is that the memory CD8 + T cell repertoire often tends to greater representation of certain Vβ families in both the Ki-67 + and Ki-67 -memory compartment, as has been seen in some (16,17) but not all studies (18).…”