Comparison of the vertical bone defect healing abilities of carbonate apatite, β-tricalcium phosphate, hydroxyapatite and bovine-derived heterogeneous bone

Abstract

The treatment of vertical bone defects caused by severe periodontal disease requires the regeneration of periodontal tissue. Although various bone substitutes have been clinically applied to vertical bone defect correction, the evaluation of these materials in periodontal tissue remains incomplete. The purpose of this study was to examine the bone regeneration abilities of various bone substitutes including Cytrans, Cerasorb, Neobone and Bio-Oss in a 3-wall bone defect animal model. All of these bone substitutes showed a similar healing ability to periodontal ligament and cementum. However, Cytrans showed the fastest bone healing ability compared with the other materials at 4 weeks post-transplantation. In addition, the recruitment of osteoclasts and endothelial cells was observed in Cytrans grafts at 4 weeks, but only detected at 8 weeks in the other materials. These results suggest that Cytrans promotes faster bone healing by inducing bone remodeling and angiogenesis.

Histomorphometric Evaluation of Bone-Guided Regeneration in Maxillary Sinus Floor Augmentation Using Nano-Hydroxyapatite/Beta-Tricalcium Phosphate Composite Biomaterial: A Case Report

“… 24 Bone defects evaluation in dogs, using micro-HA, carbonate apatite (CO 3 Ap) and β-TCP, concluded that CO 3 Ap induced a higher production of new bone, due to its superior osteoconduction and osteoinduction potential. 25 The similar potential of osteoconduction and osteoinduction was demonstrated in studies using the composition of nano-HA (80%) and β-TCP (20%). Histomorphometric/histologic evaluation indicated a higher number of bone cells (Osteocytes, osteoblasts, and osteoclasts), in addition to a higher number of blood vessels and a new bone matrix.…”

Efficacy of bone grafting materials in preserving the alveolar ridge in a canine model

“…Following transplantation of CAP, HA, and β-TCP into dog mandibles for comparison of bone formation ability, CAP formed a large volume of regenerated bone when compared with other materials at 12 weeks after transplantation 16) . CAP formed vertical bone earlier than β-TCP, HA, or BBS in a three-wall bone defect model in the canine mandible 32) . In these reports, CAP showed excellent osteoconductivity.…”

“…In this study, the implant was placed 7 weeks after transplantation of the bone grafting material, and the tissue was collected 5 weeks later. Because CAP has been reported to form bone more rapidly than other bone grafting materials 31,32) , evaluation of the regenerated bone quantity and/or quality at earlier time points may demonstrate clear differences among the materials. Additionally, β-TCP is rapidly resorbed and may not support continued maintenance of bone mass 14,15) .…”

Replacement Process of Carbonate Apatite by Alveolar Bone in a Rat Extraction Socket

“…Furthermore, from the results of Azan staining in Figure 3 B, collagen fibers (type I collagen, a main component of the organic part of bone) were abundant according to the staining concentration. The presence of collagen fibers suggests that the stained area is still immature [ 41 ]. Therefore, there was immature bone formation in the experimental group with strong staining of collagen fibers after 5 days.…”