Comparison of the total antioxidant content of 30 widely used medicinal plants of New Mexico

Vanderjagt, Timothy J.; Ghattas, R.; VanderJagt, D.J.; Crossey, Michael J.; Glew, Robert H.

doi:10.1016/s0024-3205(01)01481-3

Cited by 130 publications

(62 citation statements)

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“…A number of medicinal plants have shown antiinflammatory activities and their extracts are used for a wide range of ailments. Recently, the total antioxidant capacity of wild medicinal plants widely used in New Mexico has been investigated (1). In particular, the aqueous extracts from wild plants such as the leaves of Marubium vulgare elicit a high degree of antioxidant avtivity.…”

Section: Introductionmentioning

confidence: 99%

Anti-proliferative effect of horehound leaf and wild cherry bark extracts on human colorectal cancer cells

Yamaguchi

Liggett²,

Kim³

et al. 2006

Oncol Rep

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Marubium vulgare (horehound) and Prunus serotina (wild cherry) have been traditionally used for the treatment of inflammatory-related symptoms such as cold, fever, and sore throat. In this report, we show that extracts of anti-inflammatory horehound leaves and wild cherry bark exhibit antiproliferative activity in human colorectal cancer cells. Both horehound and wild cherry extracts cause suppression of cell growth as well as induction of apoptosis. We found that horehound extract upregulates pro-apoptotic non-steroidal anti-inflammatory drug-activated gene (NAG-1) through transactivation of the NAG-1 promoter. In contrast, wild cherry extract decreased cyclin D1 expression and increased NAG-1 expression in HCT-116 and SW480 cell lines. Treatment with wild cherry extract resulted in the suppression of β-catenin/T cell factor transcription, as assessed by TOP/FOP reporter constructs, suggesting that suppressed β-catenin signaling by wild cherry extract leads to the reduction of cyclin D1 expression. Our data suggest the mechanisms by which these extracts suppress cell growth and induce apoptosis involve enhanced NAG-1 expression and/or downregulation of β-catenin signaling, followed by reduced cyclin D1 expression in human colorectal cancer cells. These findings may provide mechanisms for traditional anti-inflammatory products as cancer chemopreventive agents.

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Section: Introductionmentioning

confidence: 99%

Anti-proliferative effect of horehound leaf and wild cherry bark extracts on human colorectal cancer cells

Yamaguchi

Liggett²,

Kim³

et al. 2006

Oncol Rep

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“…The antioxidant activity of acetone extract found better than water extract [ Table 1]. In another study, total antioxidant activity of aqueous extracts of M. vulgare determined using a two-stage Trolox based assay [101]. Results indicated that the antioxidant potential of the aqueous extracts was 560 µmol/g Trolox equivalent/g dry weights.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Marrubium vulgare L.: A review on phytochemical and pharmacological aspects

Lodhi¹,

Vadnere²,

Sharma³

et al. 2017

J Intercult Ethnopharmacol

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Marrubium vulgare L. (family: Lamiaceae), also known as the white horehound, is widely used as an herbal remedy for chronic coughs and colds. It is used in various disorders related to skin, liver, gastric, heart, and immune system. This review abridges phytochemical, pharmacological studies, and medicinal uses of M. vulgare and provides scientific proof for various ethnobotanical claims to identify gaps, which will give impulsion for novel research on M. vulgare based herbal medicines. This review summarizes selected scientific evidence on phytochemistry and pharmacological properties of M. vulgare over the past 48 years . Works related to M. vulgare was reviewed from various sources such as books, internet source, i.e., Google Search engine, PubMed, and Science Direct, and chemical abstract. The exhaustive literature was studied, and critical analysis was performed according to their phytochemical and pharmacological properties. Phytochemical investigations on different parts of M. vulgare have been reported the presence of flavonoids, steroids, terpenoids, tannins, saponins, and volatile oils (0.05%). The aerial parts contain marrubiin, together with ursolic acid and choline. Pharmacological activities such as antinociceptive, antispasmodic, antihypertensive, antidiabetic, gastroprotective, anti-inflammatory, antimicrobial, anticancer, antioxidant, and antihepatotoxic activity have been reported. M. vulgare has therapeutic potential in the treatment of inflammatory conditions, liver disorders, pain, cardiovascular, gastric, and diabetic conditions. Aerial parts of M. vulgare is a good source of labdane type diterpene especially marrubiin which is present in high concentrations. However, further scientific studies are needed to explore clinical efficacy, toxicity and to explore the therapeutic effect of major secondary metabolites such as diterpenes, phenylpropanoid, and phenylethanoid glycosides of M. vulgare.

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“…Polyphenols are very important compounds in plants because their hydroxyl groups confer free radical scavenging activity (Yang et al, 2009). Recently, it has been revealed that various polyphenolic compounds such as flavonoids, tannin, catechins, coumarin, xanthones and procyanidin could scavenge radicals (VanderJagt et al, 2002). We have tested biological activities of leaf extracts of three Thai medicinal plants, PG, RN and PO.…”

Section: Disscussionmentioning

confidence: 99%

Anti-oxidant properties and anti-hemolytic activity of Psidium guajava, Pandanous odorus and Rhinacanthus nasutus

Thephinlap¹,

Pangjit²,

Suttajit³

et al. 2013

J. Med. Plants Res.

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The ethanolic extracts of leaves of Psidium guajava (PG), Pandanous odorus (PO), Rhinacanthus nasutus (RN) contained polyphenolic compounds in the order of PG > RN > PO. All the extracts exhibited 2,2-diphenyl-1-picryhydrazyl (DPPH) and 2,2'-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals scavenging activities. PG showed a marked antioxidant effect whereas PO and RN were comparable. Interestingly, they were able to bind with ferric (Fe 3+ ) and ferrous (Fe 2+) ion and completed within 5 min of incubation times. In accordance with previous results, PG extract could effectively protect erythrocytes from iron induced hemolysis with the activity higher than PO and RN. Based on all results, tested leaf extracts of three Thai medicinal plants might be used for alleviating or preventing harmfulness in many oxidative stress disorders.

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Comparison of the total antioxidant content of 30 widely used medicinal plants of New Mexico

Cited by 130 publications

References 0 publications

Anti-proliferative effect of horehound leaf and wild cherry bark extracts on human colorectal cancer cells

Anti-proliferative effect of horehound leaf and wild cherry bark extracts on human colorectal cancer cells

Marrubium vulgare L.: A review on phytochemical and pharmacological aspects

Anti-oxidant properties and anti-hemolytic activity of Psidium guajava, Pandanous odorus and Rhinacanthus nasutus

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