Comparison of the Tolerability of Diclofenac and Nepafenac

Achiron, Asaf; Karmona, Lily; Gershoni, Assaf; Dzhanov, Yana; Gur, Zvi; Burgansky, Zvia

doi:10.1089/jop.2016.0057

Cited by 7 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subjective ocular symptoms have been measured using a visual analogue scale (VAS) (Achiron et al 2016; Data are given as mean (AESEM) or absolute number and proportion. For two-group comparisons, qualitative data were analysed with the two-factor v² test.…”

Section: Discussionmentioning

confidence: 99%

“…Subjective ocular symptoms have been measured using a visual analogue scale (VAS) (Achiron et al 2016; The number of patients reporting subjective visual acuity to reach its maximum and remain stable in above 1 week. (iv) Difficulties with the dispenser/administration of the drug.…”

Section: Discussionmentioning

confidence: 99%

“…The tolerability of nepafenac and diclofenac has proven to be similar (Achiron et al 2016). Previous studies have shown preservative-free diclofenac to have better tolerability and cause less ocular discomfort than the preserved version (Maca et al 2010).…”

Section: Introductionmentioning

confidence: 96%

“…Preand postsurgical medical interventions with topical anti-inflammatory drugs are employed to minimize postoperative inflammation and the risk of developing pseudophakic cystoid macular oedema (PCME; Donnenfeld et al 2006;Yavas et al 2007;Kim et al 2010;Kessel et al 2014;Wielders et al 2015). Different NSAID eye drops have been tested against steroids, but there have not been enough head-to-head comparisons between NSAIDs to recommend one over another (Kessel et al 2014;Sahu et al 2015;Achiron et al 2016). In clinical practice, the treatment protocol for normal and high-risk patients regarding PCME is currently shifting from topical steroid use to either application of nonsteroidal anti-inflammatory drug (NSAID) medication or a combination of both types of medication (Kessel et al 2014;Wielders et al 2015;Margulis et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…In clinical practice, the treatment protocol for normal and high-risk patients regarding PCME is currently shifting from topical steroid use to either application of nonsteroidal anti-inflammatory drug (NSAID) medication or a combination of both types of medication (Kessel et al 2014;Wielders et al 2015;Margulis et al 2017). Different NSAID eye drops have been tested against steroids, but there have not been enough head-to-head comparisons between NSAIDs to recommend one over another (Kessel et al 2014;Sahu et al 2015;Achiron et al 2016).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Postoperative management in cataract surgery: nepafenac and preservative‐free diclofenac compared

Ylinen

Taipale

Lindholm

et al. 2018

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose: Current cataract surgery guidelines recommend routine use of topical nonsteroidal anti-inflammatory drugs (NSAIDs) in preventing pseudophakic cystoid macular oedema (PCME). Here, we compare the clinical efficacy and tolerability of two potent NSAIDs, nepafenac and preservative-free diclofenac following cataract surgery. Methods: Randomized, double-blind, prospective single-centre study. Ninety-six eyes of 95 patients undergoing routine cataract surgery were randomized 1:1 either to nepafenac (Nevanac, 1 mg/ml) or diclofenac (Dicloabak, 1 mg/ml) for 3 weeks. Seventy-three patients accounting for 73 eyes completed the entire follow-up. Aqueous flare and central retinal thickness (CRT) analysis were conducted preoperatively and at control visits 28 days and 3 months after surgery. A structured home questionnaire and interview were used to record any adverse effects of the topical medications, subjective visual recovery and the dispenser's ease of use. Results: No differences were observed between the groups for aqueous flare, CRT, speed of recovery or visual acuity gain. Seven patients (16%) on nepafenac and 20 patients (48%) on preservative-free diclofenac reported symptoms related to topical use of NSAID medications (p = 0.001). Conclusion: No differences in clinical efficacy were found between potent NSAIDs, while tolerability might be an issue.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Postoperative management in cataract surgery: nepafenac and preservative‐free diclofenac compared

Ylinen

Taipale

Lindholm

et al. 2018

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

Nonsteroidal anti-inflammatory drugs for retinal neurodegenerative diseases

Chen

Wang

Zhou

et al. 2021

Prostaglandins & Other Lipid Mediators

View full text Add to dashboard Cite

Reduction of Postintravitreal Injection Pain Using Ice

Yahalomi

Hecht

Lagstein

et al. 2020

Retina

View full text Add to dashboard Cite

Purpose: Intravitreal injections of intraocular therapeutic agents are a common and effective treatment for various retinal pathologies. Patient discomfort related to injection is a potential barrier to treatment. Our aim in this study was to evaluate whether cooling the eye using topical ice compresses before intravitreal injection will reduce pain or bleeding. Methods: This randomized controlled open-label study included 42 patients. All patients received a standard topical anesthesia protocol and then were randomly assigned to either receive a placement of ice packs (intervention group) or a room-temperature pack (control group) on the eyelid, 2 minutes before the intravitreal injection. Patients' discomfort, itching, burning and pain (using visual analog scale), and bleeding size (using photographs) were measured 1 and 10 minutes after the injection. Tolerability was calculated by averaging patients' discomfort, itching, burning, and pain scores. Results: At 1 minute, pain (1.95 vs. 4.27, P = 0.01) and overall tolerability (1.66 vs. 2.98, P = 0.03) were significantly lower in patients receiving ice packs. At 10 minutes, pain (1.6 vs. 3.73, P = 0.02), burning (0.9 vs. 3.09, P = 0.007), discomfort (2.1 vs. 4.27, P = 0.008), and overall tolerability (1.23 vs. 2.87, P = 0.004) were all significantly lower in the ice group compared with the controls. Bleeding size (area or circumference) was not statistical different between groups. Conclusion: Topical ice patch administered before intravitreal injection significantly decreased pain and overall tolerability. This simple and inexpensive method may be used to ameliorated pain and improve tolerability.

show abstract

Comparison of the Tolerability of Diclofenac and Nepafenac

Abstract: Both diclofenac and nepafenac seem to have similar high tolerability. Diclofenac may be an affordable alternative to nepafenac and therefore should be considered by prescribing physicians, specifically in preoperative cataract patients.

Cited by 7 publications

References 21 publications

Postoperative management in cataract surgery: nepafenac and preservative‐free diclofenac compared

Postoperative management in cataract surgery: nepafenac and preservative‐free diclofenac compared

Nonsteroidal anti-inflammatory drugs for retinal neurodegenerative diseases

Reduction of Postintravitreal Injection Pain Using Ice

Contact Info

Product

Resources

About