Nonsteroidal anti-inflammatory drugs for retinal neurodegenerative diseases

Chen, Chen; Wang, Chenguang; Zhou, Xinru; Xu, Lingxian; Chen, Han; Qian, Kun; Jia, Bo; Su, Guanfang; Fu, Jing

doi:10.1016/j.prostaglandins.2021.106578

Cited by 8 publications

(3 citation statements)

References 102 publications

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“…Thus, various techniques were proposed to “prepare” the conjunctival tissue for surgery, from replacing topical therapy with systemic therapy, to discontinuing the most inflammatory compounds (prostaglandin analogs and alpha agonists), to switching to unpreserved medications and using steroids or non-steroidal drugs. Nevertheless, adopting these measures is not always feasible due to practical problems and the lack of precise guidelines [ 7 ]. Table 1 and Figure 2 summarize the mechanism and characteristics of the drugs that are currently used and under investigation for controlling the scarring process.…”

Section: Pharmacological Approaches Targeting the Inflammatory Respon...mentioning

confidence: 99%

Pharmacological Approaches to Modulate the Scarring Process after Glaucoma Surgery

Collotta,

Colletta,

Carlucci

et al. 2023

Pharmaceuticals

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Glaucoma is an acquired optic neuropathy that results in a characteristic optic nerve head appearance and visual field loss. Reducing the IOP is the only factor that can be modified, and the progression of the disease can be managed through medication, laser treatment, or surgery. Filtering procedures are used when target pressure cannot be obtained with less invasive methods. Nevertheless, these procedures require accurate control of the fibrotic process, which can hamper filtration, thus, negatively affecting the surgical success. This review explores the available and potential pharmacological treatments that modulate the scarring process after glaucoma surgery, analyzing the most critical evidence available in the literature. The modulation of scarring is based on non-steroidal anti-inflammatory drugs (NSAIDs), mitomycin, and 5-fluorouracil. In the long term, the failure rate of filtering surgery is mainly due to the limitations of the current strategies caused by the complexity of the fibrotic process and the pharmacological and toxicological aspects of the drugs that are currently in use. Considering these limitations, new potential treatments were investigated. This review suggests that a better approach to tackle the fibrotic process may be to hit multiple targets, thus increasing the inhibitory potential against excessive scarring following surgery.

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Section: Pharmacological Approaches Targeting the Inflammatory Respon...mentioning

confidence: 99%

Pharmacological Approaches to Modulate the Scarring Process after Glaucoma Surgery

Collotta,

Colletta,

Carlucci

et al. 2023

Pharmaceuticals

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“…Myopia, a prevalent ophthalmic disease causing global visual impairment [ 18 ], is also considered a neurodegenerative disease, particularly high myopia and pathological myopia [ 19 ]. Despite extensive research, the complete pathogenesis of myopia remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the gut microbiota and metabolite profiles in guinea pigs with form deprivation myopia through 16S rRNA gene sequencing and untargeted metabolomics

Wu,

Fan,

Feng

et al. 2024

Heliyon

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“…The pathogenesis is still poorly understood and the current hypotheses involve the breakdown of the blood-retinal barrier (BRB), the dysfunction of retinal pigment epithelium (RPE) pumps, the impairment of macular Müller cells, as well as the presence of autoimmune-related phenomena and vitreous traction 3 . Current therapeutic options rely on topical or systemic carbonic anhydrase inhibitors, nonsteroidal anti-inflammatory drugs, steroids, anti-vascular endothelial growth factors and nutraceutical supplementations, with ME often assuming chronic or recurrent courses [3][4][5][6] . Multimodal imaging techniques now offer a more thorough, non-invasive way of investigating the characteristics and impairment of retinal and choroidal structures.The main aim of the present study was to assess quantitative quantitative OCT-based imaging findings in a cohort of RP patients, to characterize the morphological features associated with the presence of ME and to investigate the clinical impact of ME on visual function and outcome.…”

mentioning

confidence: 99%

Characterizing macular edema in retinitis pigmentosa through a combined structural and microvascular optical coherence tomography investigation

Arrigo

Aragona

Perra

et al. 2023

Sci Rep

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The aim of the study was to characterize macular edema (ME) in retinitis pigmentosa (RP) by means of quantitative optical coherence tomography (OCT)-based imaging. The study was designed as observational, prospective case series, with 1-year follow-up. All RP patients underwent complete ophthalmologic assessment, including structural OCT, OCT angiography, and microperimetry (MP). The primary outcome was the characterization through quantitative OCT-based imaging of RP eyes complicated by ME. A total of 68 RP patients’ eyes (68 patients) and 68 eyes of 68 healthy controls were recruited. Mean BCVA was 0.14 ± 0.17 LogMAR at baseline and 0.18 ± 0.23 LogMAR at 1-year follow-up (p > 0.05). Thirty-four eyes (17 patients; 25%) showed ME, with a mean ME duration of 8 ± 2 months. Most of the eyes were characterized by recurrent ME. The ME was mainly localized in the inner nuclear layer in all eyes. LogMAR BCVA was similar in all RP eyes, whether with or without ME, although those with ME were associated with higher vessel density values, as well as thicker choroidal layers, than those without ME. In conclusion, the inner retina is closely involved in the pathogenesis of ME. The impairment of retinal-choroidal exchanges and Müller cell disruption might be a major pathogenic factor leading to the onset of ME in RP.

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Nonsteroidal anti-inflammatory drugs for retinal neurodegenerative diseases

Cited by 8 publications

References 102 publications

Pharmacological Approaches to Modulate the Scarring Process after Glaucoma Surgery

Pharmacological Approaches to Modulate the Scarring Process after Glaucoma Surgery

Unveiling the gut microbiota and metabolite profiles in guinea pigs with form deprivation myopia through 16S rRNA gene sequencing and untargeted metabolomics

Characterizing macular edema in retinitis pigmentosa through a combined structural and microvascular optical coherence tomography investigation

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