Comparison of the sensitivity of 11 crosslinked hyaluronic acid gels to bovine testis hyaluronidase

Sall, Ibrahima; Férard, G

doi:10.1016/j.polymdegradstab.2006.11.020

Cited by 78 publications

(95 citation statements)

References 25 publications

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“…Because these bonds remain unaffected after the crosslinking reaction, it is thought that crosslinked HA is also susceptible to enzymatic degradation. Two separate studies using a variety of BDDE-crosslinked HA fillers with different physicochemical properties showed that the BDDE modification does not interfere with the natural enzymatic degradation mechanisms of HA 31,32. Similarly, it has been shown that the BDDE modification also does not affect the susceptibility of uncrosslinked HA to oxidative degradation (D. Stroumpoulis, unpublished data).…”

Section: Degradation Of Modified Hamentioning

confidence: 96%

A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether-Crosslinked Hyaluronic Acid Dermal Fillers

Boulle¹,

Glogau²,

Kono³

et al. 2013

Dermatologic Surgery

199

175

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BackgroundCosmetic procedures are growing ever more common, and the use of soft tissue fillers is increasing. Practicing physicians need to be aware of the biological behavior of these products in tissue to enable them to respond to any safety concerns that their patients raise.ObjectivesTo provide an overview of the metabolism of 1,4-butanediol diglycidyl ether (BDDE)-crosslinked hyaluronic acid (HA) dermal fillers and to examine the safety of the resulting byproducts.MethodsA review of available evidence was conducted.ResultsAfter reaction with HA, the epoxide groups of BDDE are neutralized, and only trace amounts of unreacted BDDE remain in the product (<2 parts per million). When crosslinked HA, uncrosslinked HA, and unreacted BDDE degrade, they break down into harmless byproducts or into byproducts that are identical to substances already found in the skin.ConclusionClinical and biocompatibility data from longer than 15 years support the favorable clinical safety profile of BDDE-crosslinked HA and its degradation products. Given the strength of the empirical evidence, physicians should be confident in offering these products to their patients.

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Section: Degradation Of Modified Hamentioning

confidence: 96%

A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether-Crosslinked Hyaluronic Acid Dermal Fillers

Boulle¹,

Glogau²,

Kono³

et al. 2013

Dermatologic Surgery

199

175

View full text Add to dashboard Cite

show abstract

“…Juvéderm ULTRA contains a high proportion of crosslinked HA and comprises a smooth, cohesive gel with uniform consistency, even fl ow characteristics and extended duration due to its advanced cohesive 3D-matrix that provides high resistance to degradation (8,9). It is suitable for injection into the medium and/or deep dermis to treat moderate to severe wrinkles and folds.…”

Section: Patient Assessmentmentioning

confidence: 99%

A split‐face comparison of a new hyaluronic acid facial filler containing pre‐incorporated lidocaine versus a standard hyaluronic acid facial filler in the treatment of naso‐labial folds

Levy¹,

Boulle

Raspaldo³

2009

Journal of Cosmetic and Laser Therapy

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This split-face, single-blind study compared the comfort and ease of injection of a new hyaluronic acid facial filler containing pre-incorporated lidocaine (Juvederm ULTRA 3) versus the established hyaluronic acid facial filler Restylane-Perlane. A total of 126 individuals were treated with both products, randomly assigned to the right or left naso-labial fold. Injector assessment-indicated mean injection pain, pain of massaging the injected area and post-injection discomfort (based on a scale of 0=no pain to 10=extreme pain) were 2.1, 0.9 and 0.4 for Juvederm ULTRA 3, and 4.1, 3.3 and 1.7 for Restylane-Perlane, respectively (p<0.0001). Patient assessment of the same parameters were 2.8, 1.3 and 0.4 for Juvederm ULTRA 3, and 4.9, 3.6 and 1.8 for Restylane-Perlane (p<0.0001). Injectors indicated that 92% of Juvederm ULTRA 3 injections were 'very easy', compared with 21% for Restylane-Perlane. Post-treatment smoothness was comparable, but 95% of individuals preferred Juvederm ULTRA 3 for overall injection comfort. A total of 95% of individuals indicated that Juvederm ULTRA 3 was a more comfortable and gentle experience.

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“…The most of today commercial HA fillers are cross-linked with BDDE and unfortunately a very few numbers of analytical methods have been described in literature to follow-up the in-vitro degradation rate of BDDE-HA hydrogels. The majority of reported methods included change in viscosity, change in water content, and colorimetric assay (carbazol reaction) for the liberated glucuronic acid [13]. These methods are time-consuming, not much accurate and all of them are substantially employed to test the sensitivity of linear HA to the action of hyaluronidase.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in-vitro degradation rate of hyaluronic acid-based hydrogel cross-linked with 1, 4-butanediol diglycidyl ether (BDDE) using RP-HPLC and UV–Vis spectroscopy

Al-Sibani

Al‐Harrasi

Neubert

2015

Journal of Drug Delivery Science and Technology

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Comparison of the sensitivity of 11 crosslinked hyaluronic acid gels to bovine testis hyaluronidase

Cited by 78 publications

References 25 publications

A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether-Crosslinked Hyaluronic Acid Dermal Fillers

A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether-Crosslinked Hyaluronic Acid Dermal Fillers

A split‐face comparison of a new hyaluronic acid facial filler containing pre‐incorporated lidocaine versus a standard hyaluronic acid facial filler in the treatment of naso‐labial folds

Evaluation of in-vitro degradation rate of hyaluronic acid-based hydrogel cross-linked with 1, 4-butanediol diglycidyl ether (BDDE) using RP-HPLC and UV–Vis spectroscopy

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