A split‐face comparison of a new hyaluronic acid facial filler containing pre‐incorporated lidocaine versus a standard hyaluronic acid facial filler in the treatment of naso‐labial folds

Abstract

This split-face, single-blind study compared the comfort and ease of injection of a new hyaluronic acid facial filler containing pre-incorporated lidocaine (Juvederm ULTRA 3) versus the established hyaluronic acid facial filler Restylane-Perlane. A total of 126 individuals were treated with both products, randomly assigned to the right or left naso-labial fold. Injector assessment-indicated mean injection pain, pain of massaging the injected area and post-injection discomfort (based on a scale of 0=no pain to 10=extreme pain) were 2.1, 0.9 and 0.4 for Juvederm ULTRA 3, and 4.1, 3.3 and 1.7 for Restylane-Perlane, respectively (p<0.0001). Patient assessment of the same parameters were 2.8, 1.3 and 0.4 for Juvederm ULTRA 3, and 4.9, 3.6 and 1.8 for Restylane-Perlane (p<0.0001). Injectors indicated that 92% of Juvederm ULTRA 3 injections were 'very easy', compared with 21% for Restylane-Perlane. Post-treatment smoothness was comparable, but 95% of individuals preferred Juvederm ULTRA 3 for overall injection comfort. A total of 95% of individuals indicated that Juvederm ULTRA 3 was a more comfortable and gentle experience.

Hyaluronic acid dermal fillers: can adjunctive lidocaine improve patient satisfaction without decreasing efficacy or duration?

“…All of the studies highlighted in this article focus on the primary outcome of pain during injection and postinjection. Almost all of the studies reviewed use a filler with 0.3% lidocaine (excluding Beasley et al and Lupo et al) 1–4,8,17,18…”

“…There are several acute and delayed inflammatory and hypersensitivity reactions that are attributed to contamination of by-products from bacterial fermentation or preservatives instead of HA 1,13,20. In a European review of adverse reactions associated with dermal fillers, Andre et al reported that a small amount of proteins are found in HA dermal fillers 24.…”

“…The major determinants of facial aging are a combination of nature and nurture, including sun exposure, smoking, muscle activity, and genetics 1. Decreased collagen production, loss of elastin, muscle hyperactivity, atrophy of bone, and soft tissue structure lead to aging changes in the face.…”

Long-term efficacy, safety and durability of Juv&eacute;derm&reg; XC

“…Studies and the authors’ experience have shown that the incorporation of lidocaine to HA fillers significantly reduces pain and discomfort 18,20–22. Furthermore, returning to the previously injected area for optimal results frequently causes no more pain.…”

A Randomized Clinical Trial to Evaluate the Efficacy and Safety of Lidocaine-Containing Monophasic Hyaluronic Acid Filler for Nasolabial Folds

“…4 Therefore, more hyaluronic acid fillers are now incorporating lidocaine to reduce injection discomfort. [4][5][6][7][8][9][10] There are several studies comparing hyaluronic acid fillers with lidocaine versus those without lidocaine [5][6][7][8][9][10] ; however, to our knowledge, no recent studies have been conducted to compare two different hyaluronic acid fillers that both contain lidocaine.…”