Comparison of the Rheological Properties of Viscosity and Elasticity in Two Categories of Soft Tissue Fillers: Calcium Hydroxylapatite and Hyaluronic Acid

Sundaram, Hema; Voigts, Bob; Beer, Kenneth; Meland, Melissa

doi:10.1111/j.1524-4725.2010.01743.x

Cited by 181 publications

(164 citation statements)

References 13 publications

(16 reference statements)

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“…During implantation of viscous HAP-91 ® , it was used a caliber needle, in view of the difficulty of injecting the material at the proposed site, which is consistent with the rheological properties cited by Sundaram et al (2010). Nevertheless, no difference was observed in the behavior of animals during implantation and no difference in the clinical analysis, being the property of the biomaterial at the predetermined times of no relevance for the dermal filling.…”

Section: Resultsmentioning

confidence: 63%

“…The correction of the effects of facial aging should be directed primarily to the correction of volume as, without it, the patient continues with an aged appearance. Skin fillers have become popular for this purpose because are minimally invasive and durable, showing no potential comorbidities as a surgical procedure (Smith et al, 2007;Dayan & Bassichis, 2008;Vargas et al, 2009;Sundaram et al, 2010;Sturm et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…After implantation, these properties influence the manner in which the biomaterial will resist tension forces inherent to the site in which it was deployed, for example, facial movements. When deployed in the face, the greater elasticity of the biomaterial, the better is its resistance to skin tension forces (Sundaram et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Composite synthetic hydroxyapatite 30%, in two physical states, as dermal filler

et al. 2013

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RESUMO Compósito de hidroxiapatita sintética 30%, em dois estados físicos, como preenchedor de relevo cutâneoObjetivou-se avaliar a resposta tecidual, após implantação de hidroxiapatita sintética 30% (HAP-91 ® ), em dois estados físicos, para preenchimento cutâneo. Foram utilizados 18 coelhos da raça Nova Zelândia, distribuídos aleatoriamente em dois grupos ® fluida e viscosa) e, posteriormente, divididos em três subgrupos, de acordo com o período pós-implante, em oito, 21 e 49 dias. Em cada grupo foi implantado 1,0 mL de HAP-91 ® , fluida ou viscosa, no tecido subcutâneo, 1 cm cranial à crista da escápula direita. Foi realizada a mensuração da espessura cutânea, imediatamente antes e durante 15 dias após a implantação do compósito. Avaliações de sensibilidade dolorosa foram realizadas, atribuindo-se os escores: 0 -quando o animal permitiu o toque e não manifestou reação; 1 -quando permitiu o toque, mas manifestou reação de dor, como aumento da frequência respiratória ou tentativa de fuga; 2 -quando não permitiu o toque. Aos oito, 21 e 49 dias, foi realizada a biópsia da região implantada. Não foi observada diferença entre a espessura cutânea dos animais (p > 0,05) e todos os animais receberam escore 0 para sensibilidade dolorosa. Na análise histológica, não foi notado processo inflamatório evidente. Houve predomínio de células mononucleares, nas amostras de oito dias, e uma organização tecidual ao redor do biomaterial, com tendência ao encapsulamento. A HAP-91 ® , tanto fluida quanto viscosa, é biocompatível e indicada para o preenchimento cutâneo.Palavras-chave: implante cutâneo, compósito, medicina estética. The aim of this study was to evaluate the response to the implantation of synthetic hydroxyapatite 30% (HAP-91 ® ) in different physical states as dermal filler. Eighteen New Zealand rabbits were used, distributed randomly into two equal groups and then divided into three groups according to the postoperative period at 8, 21 and 49 days. One mL of HAP-91 ® , fluid and viscous, was implanted in the subcutaneous tissue, 1 cm proximal to the cranial crest of the right scapula. The thickness of the skin was measured before and after implantation and for the following 15 days. Pain sensitivity assessment was conducted, assigning the following scores: 0 -when the animal allowed the touch of the implant area and expressed no signs of pain; 1 -when the animal allowed the touch, but pain reaction occurred, like increase of the respiratory rate or attempt to escape; 2 -when the animal did not allow the touch to the implanted area. At 8, 21 and 49 days, biopsy of the implanted area was performed. No difference was observed between the thickness of the skin (p>0.05) and all animals received a score 0 for soreness. Histological analysis did not reveal any obvious inflammatory process, showing a predominance of mononuclear cells in samples of eight days and tissue organization around the biomaterial with a tendency to encapsulation. The results indicate that HAP-91 ® , both viscous and fluid, is biocompatible...

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Section: Resultsmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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Composite synthetic hydroxyapatite 30%, in two physical states, as dermal filler

et al. 2013

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“…• Use a filler with high viscosity and elasticity that provides volume-efficient lifting and stable postinjection contours [6].…”

Section: Discussionmentioning

confidence: 99%

Structured Nonsurgical Asian Rhinoplasty

Kim¹,

Ahn

2012

Aesth Plast Surg

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The Asian nose is characterized by a flat nasal bridge, indistinct dorsal aesthetic line, an underprojected and broad nasal tip, and a short columella. Cosmetic procedures to enhance these features are popular in Asians and surgical rhinoplasty is the therapeutic gold standard for individuals seeking to enhance the appearance of their nose. However, in recent years, there appears to be an increasing number of Asians seeking nonsurgical rhinoplasty and this tendency is seen in both primary and revision cases. The biggest strength of filler rhinoplasty is that it is minimally invasive, has a good safety record, provides immediately visible results, and can be done conveniently in the office setting without the downtime of surgery. Despite its temporary longevity, it is popular because it is simple, effective, and economical. This article describes a "structured" nonsurgical Asian rhinoplasty approach using dermal fillers that can produce a comprehensive cosmetic enhancement of the Asian nose.

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“…The differences in their respective properties have been described in the literature (Sundaram and Cassuto 2013 ;Sundaram et al 2010 ). We primarily use Restylane for revolumization in the upper and lower lids.…”

Section: Techniquementioning

confidence: 98%