Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy

Liu, Chun-Hsiu; Wu, Wei‐Chi; Sun, Ming‐Hui; Kao, Ling-Yuh; Lee, Yung-Sung; Chen, Henry Shen-Lih

doi:10.1167/iovs.17-22021

Cited by 30 publications

(54 citation statements)

References 33 publications

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“…A significant correlation was found between the OCTA parameters and visual field MD, between OCTA parameters and glaucoma stage, and, as previously described, between the OCTA and OCT parameters in the peripapillary area [6, 17-20, 22-24, 26, 28-30, 33, 35, 36, 38, 39, 41, 45, 48, 50, 71-75], the optic disc [19, 23, 29, 36, 51-53, 57, 58], and the macular area [21, 36, 38, 61, 62, 64, 69, 75, 76]. As mentioned above, the results for the parafoveal area were not significant in some of the studies [38, 70].…”

Section: Resultssupporting

confidence: 72%

“…As mentioned above, the results for the parafoveal area were not significant in some of the studies [38, 70]. Vessel density defects (measured with OCTA) were spatially associated with OCT and visual field defects in the 3 above-mentioned regions [6, 17, 18, 20-24, 29, 30, 45, 48, 69, 72, 74, 76-78].…”

Section: Resultsmentioning

confidence: 96%

“…Significantly lower OCTA parameters (vessel density, blood flow index, and flow index) were found in glaucoma eyes in comparison with normal eyes in the peripapillary area [6, 16-50], the optic disc [19, 23, 25, 32, 36, 51-60] and the whole image macular area [16, 21, 32, 34, 36-38, 61-64]. In all of those areas, the diagnostic abilities increased with increasing severity of glaucoma [32, 34, 52].…”

Section: Resultsmentioning

confidence: 99%

“…However, the results regarding the parafoveal and foveal areas were not consensual, with some studies reporting a significant difference [32, 34, 36, 38, 68, 69] and others not [32, 37]. The macular sectors that were found to be the most vulnerable to glaucoma, i.e., the supero- and inferotemporal areas, were lying mostly outside of the central, parafoveal area [21, 67].…”

Section: Resultsmentioning

confidence: 99%

“…Most studies investigated the OCTA parameters in the superficial layers (above the inner plexiform layer) [3, 16, 18, 20-22, 25-29, 32-38, 41, 45, 47, 48, 50, 61-63, 69-71, 75-77, 85-88] or in the full-thickness scan [6, 17, 19, 21, 23, 30, 36, 39, 46, 51-54, 56-58, 62, 72, 83]. …”

Section: Resultsmentioning

confidence: 99%

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Optical Coherence Tomography Angiography in Glaucoma: A Review

et al. 2018

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Background: Glaucoma is the leading cause of irreversible blindness worldwide. Several techniques exist for the diagnosis and follow-up of patients. Optical coherence tomography (OCT) angiography (OCTA) is a recently developed technique that provides a quantitative assessment of the microcirculation of the retina and choroid in a fast, noninvasive way. Despite it being a novel technique, several publications have already been done in the glaucoma field. However, a summary of findings is currently lacking. Aims: To perform a literature review to assess the role of OCTA in glaucoma diagnosis and follow-up. Methods: A database search was carried out using MEDLINE, Embase, and Web of Science, including all original works registered until July 23, 2017. Results: OCTA (1) has a high repeatability and reproducibility, (2) has good discriminatory power to differentiate normal eyes from glaucoma eyes, (3) is more strongly correlated with visual function than conventional OCT, (4) has good discriminatory power to differentiate early-glaucoma eyes from normal eyes (i.e., at least equal to that of OCT), (5) reaches a floor effect at a more advanced disease stage than OCT, and (6) is able to detect progression in glaucoma eyes. Conclusion: OCTA shows potential to become a part of everyday glaucoma management.

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