Comparison of the quantification precision of human short echo time1H spectroscopy at 1.5 and 4.0 Tesla

Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease

“…Several software packages have been developed specifically for MRS data quantification, including: (1) LCModel [45], widely used for automatic quantification of in vivo proton MR spectra, is a commercial software that accepts time-domain data input and generates one-page summary output through non-interactive, operator-independent analyses; (2) PROBE-Q [46], an on-line program embedded in the General Electric Medical System, displays and processes MRS spectra to provide measures of metabolite peak heights and ratios while they are acquired; (3) fitMANSuite [47, 48], a comprehensive MRS processing and qualification package in either time domain or frequency domain, has been used mostly in handling data acquired at high-fields using the LASER pulse sequence with a short TE; and (4) jMRUI [49], a distributed software package for time domain MRS and MRSI analysis that has a user-friendly graphical interface and uses a semi-parametric algorithm based on quantification of uncertainty in extreme scale computations.…”

“…( 1 ) shows in vitro SV 1 H MRS spectra at 1.5T and at 4.0T. At high fields, all metabolites show greater frequency dispersion, resulting in greater discrimination of peaks with similar chemical shift values, leading to more reliable quantification [48, 54-56]. For example, at 3.0T a peak at 3.91 ppm for creatine and at 3.93 ppm for phosphorylated creatine can be identified, while the mI peak can be resolved into peaks at 3.55 and 3.61 ppm.…”

Proton Magnetic Resonance Spectroscopy

“…With any increase in magnetic field strength, there is a decrease in metabolite T2* relaxation times resulting in increased metabolite line widths. 10 It is important to mention that other post-processing factors also influence the overall appearance of the peaks (i.e. spectral apodization as known as line broadening) (Fig.2).…”

In vivo proton MR spectroscopy of the human brain

“…In vivo MRS of the human brain has been reported at a range of field strengths including 0.5 [118] [122,124,125]. At low fields (<1.5 T), chemical shift resolution is reduced and SNR lower than at 1.5 T, although interestingly some of the most strongly coupled multiplets (such as those from glutamate) start to coalesce into a single resonance, giving a high signal intensity [118].…”