In vivo proton MR spectroscopy of the human brain

Barker, Peter B.; Lin, Doris

doi:10.1016/j.pnmrs.2006.06.002

Cited by 113 publications

(135 citation statements)

References 246 publications

(292 reference statements)

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“…41,42 The advantages and disadvantages of a variety of different approaches to whole-brain CSI have been discussed in detail by Barker and Lin 26 and Keevil. 24 A comparison of the performance of many of these CSI methods has been provided by Pohmann et al 43 Barker and Lin 26 have an excellent discussion of methods that use multireceiver arrays (e.g., an eightchannel head array) to accelerate CSI acquisitions, similar to the methods used in parallel imaging. An added complication is that, although there have been descriptions of algorithms 44,45 used in combining CSI spectra obtained from each individual coil element, few of these are routinely available on commercial whole-body clinical scanners.…”

Section: Spatial Localizationmentioning

confidence: 99%

“…28,56 -59 This proposed role for NAA implies that NAA changes might be reversible, an observation that has been made in several human studies including MS, acquired immunodeficiency syndrome (AIDS), and temporal lobe epilepsy. 26 …”

Section: N-acetylaspartatementioning

confidence: 99%

“…Barker and Lin 26 have provided an excellent discussion of the effects of dynamic susceptibility broadening on the apparent T 2 of a given resonance. They point out that, although the real T 2 of a resonance such as that of NAA (measured with a CPMG sequence) does not change with field strength, the T 2 determined with a single spin echo becomes much shorter at higher fields, due to the effects of dynamic susceptibility broadening.…”

Section: Is Proton Mrs Of Human Brain Better At Fields Higher Than 1mentioning

confidence: 99%

“…[25][26][27][28] Here, we will describe the localization methods currently used in MRS studies of the…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Magnetic Resonance Neurospectroscopy

Rosen

Lenkinski

2007

Neurotherapeutics

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Summary:Over the past two decades, proton magnetic resonance spectroscopy (proton MRS) of the brain has made the transition from research tool to a clinically useful modality. In this review, we first describe the localization methods currently used in MRS studies of the brain and discuss the technical and practical factors that determine the applicability of the methods to particular clinical studies. We also describe each of the resonances detected by localized solvent-suppressed proton MRS of the brain and discuss the metabolic and biochemical information that can be derived from an analysis of their concentrations. We discuss spectral quantitation and summarize the reproducibility of both single-voxel and multivoxel methods at 1.5 and 3-4 T. We have selected three clinical neurologic applications in which there has been a consensus as to the diagnostic value of MRS and summarize the information relevant to clinical applications. Finally, we speculate about some of the potential technical developments, either in progress or in the future, that may lead to improvements in the performance of proton MRS.

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Section: Spatial Localizationmentioning

confidence: 99%

Section: N-acetylaspartatementioning

confidence: 99%

Section: Is Proton Mrs Of Human Brain Better At Fields Higher Than 1mentioning

confidence: 99%

“…[25][26][27][28] Here, we will describe the localization methods currently used in MRS studies of the…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances in Magnetic Resonance Neurospectroscopy

Rosen

Lenkinski

2007

Neurotherapeutics

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“…It is reported that NAA reduces significantly in the cerebellum of patients with cerebellar degeneration (21) and familial hemiplegic migraine type 1 (22). Although absolute concentration measurement of metabolite is important, many studies do not attempt to quantify absolute metabolite concentrations, but rather report relative ratio of each metabolite, often using Cr as a reference (23). Quantification based on metabolite ratio was adopted in this study.…”

Section: Resultsmentioning

confidence: 99%

High‐resolution MRS in the presence of field inhomogeneity via intermolecular double‐quantum coherences on a 3‐T whole‐body scanner

Lin

Chen

et al. 2010

Magnetic Resonance in Med

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Signals from intermolecular double-quantum coherences (iDQCs) have been shown to be insensitive to macroscopic field inhomogeneities and thus enable acquisition of highresolution MR spectroscopy in the presence of large inhomogeneous fields. In this paper, localized iDQC 1 H spectroscopy on a whole-body 3-T MR scanner is reported. Experiments with a brain metabolite phantom were performed to quantify characteristics of the iDQC signal under different conditions. The feasibility of in vivo iDQC high-resolution MR spectroscopy in the presence of large intrinsic and external field inhomogeneity (in the order of hundreds of hertz) was demonstrated in the whole cerebellum of normal volunteers in a scan time of about 6.5 min. Major metabolite peaks were well resolved in the reconstructed one-dimensional spectra projected from two-dimensional iDQC acquisitions. Investigations on metabolite ratios, signal-to-noise ratio, and line width were performed and compared with results obtained with conventional point-resolved spectroscopy/MR spectroscopy in homogeneous fields. Metabolite ratios from iDQC results showed excellent consistency under different in vitro and in vivo conditions, and they were similar to those from point-resolved spectroscopy with small voxel sizes in homogeneous fields. MR spectroscopy with iDQCs can be applied potentially for quantification of gross metabolite changes due to diseases in large brain volumes with high field inhomogeneity. Magn Reson Med 63:303-311, 2010. V C 2010 Wiley-Liss, Inc.Key words: intermolecular double-quantum coherences (iDQCs); inhomogeneous broadening; high-resolution; localized spectroscopy; human cerebellumIn vivo magnetic resonance spectroscopy (MRS) allows noninvasive analysis of metabolites in humans. It is widely used for investigation of pathogenesis, monitoring metabolite responses, and clinical diagnosis of cancers and various neurologic diseases. However, magnetic field homogeneity in vivo is often degraded by magnetic susceptibility variation near, for example, air/tissue interfaces, bones and cerebrospinal fluid in brain, or with large interferences from fat and other fluid signals in the prostate. The field distortions can be as large as 2.0 part per million (ppm) over a 20 Â 20 Â 20 mm 3 voxel (1) and are not well corrected with the 1st-and 2nd-order shimming available in most clinical MR scanners. Under such circumstances, spectra obtained by conventional MRS techniques are often poor and unusable. One way to remove the effect of inhomogeneous fields up to hundreds of hertz is to use techniques based on intermolecular multiple-quantum coherences that originate from dipole-dipole interactions between spins of different molecules. Intermolecular zero-quantum coherences (iZQCs) have been explored to obtain high-resolution spectra from nonlocalized controlled inhomogeneous samples (2-4) and biologic samples (5-7) at high magnetic fields. Localized iZQC spectra of living animals were also obtained on a 17.6-T spectrometer (8,9). In comparison to the iZQCs, previous...

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Accelerated Spatially Encoded Spectroscopy of Arbitrarily Shaped Compartments Using Prior Knowledge and Linear Algebraic Modeling

Bottomley

Zhang

2015

eMagRes

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In vivo proton MR spectroscopy of the human brain

Cited by 113 publications

References 246 publications

Recent Advances in Magnetic Resonance Neurospectroscopy

Recent Advances in Magnetic Resonance Neurospectroscopy

High‐resolution MRS in the presence of field inhomogeneity via intermolecular double‐quantum coherences on a 3‐T whole‐body scanner

Accelerated Spatially Encoded Spectroscopy of Arbitrarily Shaped Compartments Using Prior Knowledge and Linear Algebraic Modeling

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