Comparison of the prognostic value of C-Reactive protein and troponin I in patients with unstable angina pectoris

Benamer, Hakim; Steg, Philippe Gabriel; Bénessiano, Joëlle; Vicaut, Éric; Gaultier, C; Boccara, Albert Claude; Aubry, P; Nicaise, Pascale; Brochet, Éric; Juliard, Jean-Michel; Himbert, Dominique; Assayag, Patrick

doi:10.1016/s0002-9149(98)00490-1

Cited by 98 publications

(65 citation statements)

References 21 publications

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“…In acute coronary syndromes, hs-CRP predicts recurrent myocardial infarction independent of troponins, which suggests it is not merely a marker for the extent of myocardial damage. [52][53][54] Recent data also suggest that hs-CRP may be a marker for risk of restenosis after PCIs, 55,56 but all studies are not in agreement with these results. 57 Elevated hs-CRP levels also seem to predict prognosis and recurrent events in patients with stroke 58,59 and peripheral arterial disease.…”

Section: B Prediction Of Recurrent Cvd Events and Death: Secondary Pmentioning

confidence: 98%

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Markers of Inflammation and Cardiovascular Disease

Pearson¹,

Mensah²,

Alexander³

et al. 2003

Circulation

5,348

2,141

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Section: B Prediction Of Recurrent Cvd Events and Death: Secondary Pmentioning

confidence: 98%

“…hs-CRP consistently predicts new coronary events in patients with unstable angina and acute myocardial infarction. [42][43][44][45][46][47][48][49][50][51] Most of these studies have been long term, but some in-hospital survivorship studies [52][53][54] have also shown an association.…”

Section: B Prediction Of Recurrent Cvd Events and Death: Secondary Pmentioning

confidence: 99%

Markers of Inflammation and Cardiovascular Disease

Pearson¹,

Mensah²,

Alexander³

et al. 2003

Circulation

5,348

2,141

View full text Add to dashboard Cite

“…1992;Gohkan Cin, Gok & Kaptanoglu 1996;Stubbs et al 1996;Kerr & Dunt 1997;Luscher et al 1997;Pettijohn et␣ al.␣ 1997;Benamer et al 1998;Brscic et al 1998;Olatidoye et al 1998;Polamczyk et al 1998), and…”

Section: Discussionunclassified

Managing unstable angina and coronary care beds effectively

Kelly

Edmonds²,

Newman³

et al. 1999

Aust. Health Review

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“…Nineteen studies were selected; 15 were carried out by North American or European groups 1,[14][15][16][17][18][19][20][21][22][23][24][25][26][27] , three by Brazilian groups [28][29][30] and one by an Argentinean group 31 . All these studies were published in journals with an impact factor ≥ 3, except for two Brazilian studies 28,29 .…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…The sample size of the studies increased throughout the years, ranging from 32 to 7,108 patients (mean of 1,123 ± 1,674); seven studies had more than 1,000 patients 20,21,[23][24][25][26][27] , in a total of 21,339 patients studied. C-reactive protein was measured in all studies by means of a high-sensitivity method; 11 used nephelometry [14][15][16][17][18][19][21][22][23][24]26,[28][29][30] , three used turbidimetry 1,25,27 , one used luminometry 20 , and two used ELISA (Enzyme Liked Immunosorbent Assay) 31 .…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Proteína C-reativa e prognóstico em síndromes coronarianas agudas: revisão sistemática e metanálise

Correia¹,

Esteves²

2011

Arq. Bras. Cardiol.

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Despite the association between high-sensitivity C-reactive protein (CRP) and recurrent events in non-ST elevation acute coronary syndromes (ACS), routine determination of this marker has not been recommended.In order to verify whether the current scientific evidence justifies the inclusion of CRP for risk stratification at hospital admission of patients with ACS, we carried out a systematic review and meta-analysis of the studies indexed in MEDLINE, SciELO or LILACS, with the following inclusion criteria: prospective cohort design and assessment of the prognostic value of CPR, as measured using a high-sensitivity method at the moment of hospital admission of patients with ACS. Nineteen studies met the inclusion criteria.In relation to the long-term follow-up, there was a consistent association between CRP and cardiovascular events, with an overall odds ratio (OR) of 4.6 (95% CI = 2.3 -7.6) and overall multivariate OR of 2.5 (95% CI = 1.8-3.4). As for the short-term, nine studies were positive and six were negative, with an overall OR of 1.65 (95% CI = 1.2-2.3). The overall multivariate OR was not obtained for the short-term follow-up, because this measurement was described only in three heterogeneous studies. Only two short-term studies analyzed the incremental predictive value of CRP in relation to multivariate models, with contradicting results.In conclusion, the small number of assessments of the incremental value of CRP, in conjunction with controversial results regarding the independent predictive value of CRP for short-term events does not support the recommendation of the routine use of CRP for risk stratification at admission of patients with ACS.

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Comparison of the prognostic value of C-Reactive protein and troponin I in patients with unstable angina pectoris

Cited by 98 publications

References 21 publications

Markers of Inflammation and Cardiovascular Disease

Markers of Inflammation and Cardiovascular Disease

Managing unstable angina and coronary care beds effectively

Proteína C-reativa e prognóstico em síndromes coronarianas agudas: revisão sistemática e metanálise

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