Markers of Inflammation and Cardiovascular Disease

Pearson, Thomas A.; Mensah, George A.; Alexander, R. Wayne; Anderson, Jeffrey L.; Cannon, Richard O.; Criqui, Michael H.; Fadl, Yazid Y.; Fortmann, Stephen P.; Hong, Yuling; Myers, Gary L.; Rifai, Nader; Smith, Sidney C.; Taubert, Kathryn A.; Tracy, Russell P.; Vinicor, Frank

doi:10.1161/01.cir.0000052939.59093.45

Cited by 5,335 publications

(2,174 citation statements)

References 115 publications

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“…Although various new pharmacological approaches have been introduced to reduce hs‐CRP levels17, 18, 19, 20, 21, 22, 23, 24, 25, 26, there are still many cardiovascular diseases all over the world. In the present study, serum hs‐CRP levels were lower in patients with a larger number of risk factors reaching a desired value (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

“…In consequence, CRP could be strongly responsible for foam cell formation in atherogenesis20. Furthermore, the Centers for Disease Control and Prevention and the American Heart Association gave the guidelines that we should use to measure hs‐CRP levels in patients who have cardiovascular risks21. Various new pharmacological approaches have been introduced to reduce hs‐CRP levels22, 23, 24, 25, 26.…”

Section: Introductionmentioning

confidence: 99%

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Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients

Shimoda

Kaneto

Yoshioka

et al. 2015

J of Diabetes Invest

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Aims/IntroductionIncreased levels of high‐sensitivity C‐reactive protein (hs‐CRP) likely leads to the development of atherosclerosis. Therefore, it is very important to know which factors largely influence hs‐CRP levels. In the present study, we examined the influence of various atherosclerosis‐related factors on hs‐CRP levels in patients with type 2 diabetes.Materials and MethodsA total of 275 patients (176 men, 99 women) were enrolled in this study. We tested the relationship between the number of risk factors reaching a desired value and hs‐CRP levels. The Mann–Whitney U‐test was used to compare two groups. The Kruskal–Wallis test was used to carry out overall group comparisons, and the Steel–Dwass test was used to carry out between‐group comparisons. Spearman's rank correlation was carried out to study the correlation between hs‐CRP levels and clinical parameters. Multivariate regression method was used to analyze the factors independently contributing to hs‐CRP levels.ResultsHs‐CRP levels were lower in patients with a larger number of risk factors reaching a desired value. In particular, triglyceride and body mass index (BMI) were independent risk factors determining hs‐CRP levels in a multivariate regression analysis. Furthermore, we compared the influence of various factors on hs‐CRP levels in both obese (BMI ≥25 kg/m2) and non‐obese patients with type 2 diabetes (BMI <25 kg/m2). In obese groups, BMI and urinary albumin were independent risk factors determining hs‐CRP levels, whereas triglyceride and statin were independent risk factors in non‐obese patients.ConclusionsThere is some difference in the factors responsible for hs‐CRP levels in obese and non‐obese patients with type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients

Shimoda

Kaneto

Yoshioka

et al. 2015

J of Diabetes Invest

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“…The hs‐CRP concentrations were categorized into two groups as follows16: high level (hs‐CRP+, >3 mg/L) and low level (hs‐CRP−, <3 mg/L).…”

Section: Methodsmentioning

confidence: 99%

Association between high‐sensitivity C‐reactive protein, lipoprotein‐associated phospholipase A2 and carotid atherosclerosis: A cross‐sectional study

Liu

Yao

Wang

et al. 2018

J Cellular Molecular Medi

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High‐sensitivity C‐reactive protein (hs‐CRP) and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) have been reported to be independent predictors of atherosclerosis. However, whether the combination of these two markers can improve the prediction of atherosclerosis is unknown. This study aimed to evaluate the association between combining hs‐CRP and Lp‐PLA2 and predicting carotid atherosclerosis. A total of 1982 participants aged ≥40 years were included in this study. Hs‐CRP and Lp‐PLA2 were measured by a high‐sensitivity nephelometry assay and quantitative sandwich enzyme‐linked immunosorbent assay, respectively. Ultrasonography was performed on the bilateral carotid arteries to evaluate stenosis and plaques. Multivariable logistic regression models were used to analyse the association between the combination of the hs‐CRP and Lp‐PLA2 levels and carotid plaques and stenosis. A total of 1579 (79.7%) and 181 (9.1%) subjects had carotid plaques and carotid stenosis, respectively. The group with high hs‐CRP and Lp‐PLA2 levels had the highest prevalence of carotid plaques (90.6%) and stenosis (20.8%). A significant association was found between high hs‐CRP and Lp‐PLA2 levels and carotid stenosis (adjusted odds ratio [OR]: 2.39; 95% confidence interval [CI]: 1.13‐5.09), but this combination was not associated with carotid plaques (OR: 2.62, 95% CI: 0.93‐7.38). The results suggested that the combination of hs‐CRP and Lp‐PLA2 were better predictors than either protein alone with regard to carotid atherosclerosis.

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“…Participants were divided into 3 groups according to risk category of hsCRP (low hsCRP group <1.0 mg/L, median hsCRP group 1.0–3.0 mg/L, high hsCRP group >3.0 mg/L)18 or according to tertiles of hsCRP level. The baseline characteristics among the 3 groups were analyzed by ANOVA for parametric variables, the Kruskal–Wallis test for nonparametric variables, and the χ 2 test for categorical variables.…”

Section: Methodsmentioning

confidence: 99%

Prognostic Significance of Plasma High‐Sensitivity C‐Reactive Protein in Patients With Hypertrophic Cardiomyopathy

Zhu

Zou

Wang

et al. 2017

JAHA

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BackgroundElevated high‐sensitivity C‐reactive protein (hsCRP) has been associated with increased risks of adverse outcomes of various cardiovascular diseases. The relationship between hsCRP and the prognosis of hypertrophic cardiomyopathy remains to be evaluated.Methods and ResultsThe study used an observational cohort methodology. A total of 490 patients were enrolled in the Fuwai Hospital from 2001 to 2011 and were followed for 3.7±2.0 years. According to the risk category of hsCRP, subjects in the high hsCRP group (>3.0 mg/L) had a higher risk of developing adverse events than the low hsCRP group (<1.0 mg/L): cardiovascular death (adjusted hazard ratios[HR] 5.41, 95% CI 1.96–14.93, P=0.001), all‐cause mortality (adjusted HR 4.78, 95% CI 1.99–11.47, P<0.001), sudden cardiac death (adjusted HR 11.29, 95% CI 1.38–92.20, P=0.024), and heart failure–related death (adjusted HR 4.38, 95% CI 1.15–16.60, P=0.030). Similarly, the continuous variable of hsCRP was also an independent predictor for adverse outcomes: cardiovascular death (adjusted HR 1.15, 95% CI 1.06–1.25, P=0.001), all‐cause mortality (adjusted HR 1.17, 95% CI 1.09–1.26, P<0.001), sudden cardiac death (adjusted HR 1.20, 95% CI 1.06–1.36, P=0.003), and heart failure–related death (adjusted HR 1.15, 95% CI 1.02–1.30, P=0.020).ConclusionsOur results indicate that elevated plasma hsCRP is associated with increased risk for adverse outcomes in patients with hypertrophic cardiomyopathy.

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Markers of Inflammation and Cardiovascular Disease

Cited by 5,335 publications

References 115 publications

Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients

Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients

Association between high‐sensitivity C‐reactive protein, lipoprotein‐associated phospholipase A2 and carotid atherosclerosis: A cross‐sectional study

Prognostic Significance of Plasma High‐Sensitivity C‐Reactive Protein in Patients With Hypertrophic Cardiomyopathy

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