Comparison of the pattern of metastatic spread of squamous cell cancer and adenocarcinoma of the uterine cervix

Cw, Drescher; Hopkins, M.P.; Ja, Roberts

doi:10.1016/0020-7292(90)90229-e

Cited by 3 publications

(3 citation statements)

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“…One striking difference between currently reported literature data and our case report is the metastatic site. Current literature data suggest that cervix uteri AS/AC are associated with higher rates of ascites, abdominal carcinomatosis, and para-aortic and supraclavicular spread [5, 9, 14]. However, our patient presented with a biopsy-proven left pulmonary hilum metastasis.…”

Section: Discussionmentioning

confidence: 67%

Changing the Prognosis of Metastatic Cervix Uteri Adenosquamous Carcinoma through a Multimodal Approach: A Case Report

Géorgescu

Georgescu

et al. 2020

Case Rep Oncol

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Adenocarcinoma and adenosquamous carcinoma (AS) are 2 rare histological types of cervix uteri cancer constituting almost 20% of all cervix cancers, leading to a lack in patient management guidelines. We report the case of a 32-year-old woman with an oligometastatic cervix AS for which a multimodal treatment approach was used. Despite the patient’s bad prognosis, a complete response was achieved, which further resulted in excellent local control and prolonged survival. This case report serves the purpose of encouraging multidisciplinary team work and out-of-the-box thinking that should result in an individualized treatment for rare cancer subtypes.

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Section: Discussionmentioning

confidence: 67%

Changing the Prognosis of Metastatic Cervix Uteri Adenosquamous Carcinoma through a Multimodal Approach: A Case Report

Géorgescu

Georgescu

et al. 2020

Case Rep Oncol

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“…Bone metastasis is an undesired, but frequent course of certain cancers, particularly breast and prostate cancer, and less frequently, cancers of the lungs and kidneys [12]. The recent literature has described head and neck metastasis from uterine cervical cancer [13,14]. In fact, there were 19 cases of metastatic cancers in the mandibular condyle over the 56-year period between 1956 and 2012 ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

Metastatic adenocarcinoma of the mandibular condyle from uterine cervix: Report of a case

Sugiyama

Ohyama

Kiyoshima

et al. 2013

Oral Science International

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a b s t r a c tMetastasis to the mandibular condyle is rare, and such lesions should be identified by both clinical and pathological examinations. We experienced a case of adenocarcinoma occurring in the right mandibular condyle. A 65-year-old female with uterine cervical cancer showed condylar dysfunction. Imaging examinations revealed a tumor with bone destruction and a rapidly progressive course, while pathological examinations suggested metastasis originating from another site. Based on the clinical and pathological findings, the patient was diagnosed with condylar metastasis derived from the uterine cervix, in addition to a recurrence of uterine cervical cancer.

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“…Adenocarcinoma of the cervix is being recognized with increasing frequency in diagnostic practice and is said to account for as much as 15% of invasive cervical neoplasia. The natural history of cervical adenocarcinoma is said to differ from the natural history of squamous carcinoma of the cervix since it has been reported to have an increased propensity to metastasize to local lymph nodes (8)(9)(10) . Such a variation in behavior associated with different histological subtypes of cervical carcinoma may be explained by differences in integrin expression.…”

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confidence: 99%

Integrin expression in cervical carcinoma

Heatley¹,

Corke²

1998

Int J Gynecol Cancer

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Heatley MK, Corke K. Integrin expression in cervical carcinoma. Int J Gynecol Cancer 1998; 8: 203–206. Integrin expression was studied in a series of 36 cervical carcinomas using antibodies to integrins αvβ5, α3, β1 and β4. Integrins αvβ5, α3 and β1 were localized to the cell membrane in well differentiated (0/13, 2/4 and 4/14 cases) and moderately differentiated adenocarcinomas (0/6, 1/5 and 1/6 cases, respectively) and in adenosquamous (2/6, 2/5 and 3/6) well differentiated (1/4, 0/3, and 3/5) and moderately differentiated (1/2, 1/3 and 1/3) squamous cell carcinomas. Two antibodies (AA3 and 439‐B) located integrin β4 to the cell membranes and cytoplasm of well (13/13 and 10/12 cases) and moderately differentiated (6/7 and 5/6 cases) adenocarcinomas, cases of adenosquamous carcinoma (6/6 and 5/6 cases), and well (4/4 and 3/4 cases) and moderately (3/3 and 3/4 cases) differentiated squamous cell carcinomas. In conclusion, integrin expression was identified most frequently with the antibodies to β4 which was localized to cervical carcinomas of varying grades and histological types. Immuno‐staining was identified less frequently with the antibodies to αvβ5, α3 and β1.

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Comparison of the pattern of metastatic spread of squamous cell cancer and adenocarcinoma of the uterine cervix

Cited by 3 publications

References 0 publications

Changing the Prognosis of Metastatic Cervix Uteri Adenosquamous Carcinoma through a Multimodal Approach: A Case Report

Changing the Prognosis of Metastatic Cervix Uteri Adenosquamous Carcinoma through a Multimodal Approach: A Case Report

Metastatic adenocarcinoma of the mandibular condyle from uterine cervix: Report of a case

Integrin expression in cervical carcinoma

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