Comparison of the New Low-Cost Nonvalved Glaucoma Drainage Device with Ahmed Glaucoma Valve in Refractory Pediatric Glaucoma in Indian Eyes

Senthil, Sirisha; Gollakota, SriRamani; Ali, Mohammed; Turaga, Kiranmaye; Badakere, Swathi; Krishnamurthy, Rashmi; Garudadri, Chandra S.

doi:10.1016/j.ogla.2018.07.001

Cited by 26 publications

(20 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, as demonstrated in this study and others, the incidence of postoperative hypotony is less. 3 8 16 19 32 In our study, seven children developed transient choroidal detachment in the AADI group compared with only one in the AGV group. All the eight patients had resolution of the choroidal detachment without any surgical intervention and none of them persisted more than 2 months.…”

Section: Discussionmentioning

confidence: 47%

“… 2 3 5 6 8 18 In children, Kaushik et al 4 found that the AADI had a cumulative probability of success of 91.2% at 6 months and 81.7% at 18–24 months. Senthil et al 3 reported for the AADI group a cumulative probability of qualified success of 91.6% at 12 months and 81% at 36 months, while for the AGV group 88.1% at 12 months and 85% at 36 months, with no statistical significance, but complete success was significantly higher in AADI. Similar findings were observed in large controlled trials in adults that compared non-valved BGI with AGV.…”

Section: Discussionmentioning

confidence: 97%

“… 2 5 6 Similarly, in paediatric glaucoma, the AADI has shown greater complete success with better IOP control and less number of AGMs. 3 However, while studies showed similarity or superiority of the AADI compared with the AGV, 2 3 5 8 the majority of reports have emanated from India, the country of origin of AADI, and studied Indian eyes only. 2–6 8–11 Of the two studies in Middle Eastern populations, one conducted in a mixed adult and paediatric population reported favourable outcomes, 12 while another in younger children reported a high adverse event profile.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surgical outcomes of the Aurolab aqueous drainage implant (AADI) versus the Ahmed glaucoma valve for refractory paediatric glaucoma in Middle Eastern children

et al. 2021

View full text Add to dashboard Cite

ObjectiveThe Aurolab aqueous drainage implant (AADI) has the potential advantages of less encapsulation and greater cost-effectiveness than the Ahmed glaucoma valve (AGV). The aim of this study was to compare the surgical success and outcomes of the AADI compared to the AGV in Middle-Eastern children.MethodsA comparative retrospective study of consecutive paediatric patients in a tertiary eye hospital was undertaken. Data collected included demographics, type of glaucoma, intraocular pressure (IOP), number of anti-glaucoma medications (AGMs) and any subsequent complications or further surgeries.AnalysisThe mean IOP, number of AGMs, surgical success and number of reoperations was compared for the two groups. Surgical success at each visit was defined as IOP of ≥6 mm Hg and ≤21 mm Hg or if the reduction of IOP was ≥20% reduced from baseline.ResultsA total of 126 tube surgeries (56 eyes in AADI and 70 eyes in AGV) were performed in patients aged ≤18 years from 2014 to 2019. No difference was observed in the mean IOP between the two groups except at the first month post-operative visit. After six months, the AADI group had a consistently significant lower mean number of AGMs. At last follow-up, 21 (37.5%) eyes in the AADI group were glaucoma medication-free vs 15 (21.4%) eyes in the AGV group (pp=0.047). Kaplan-Meier analysis showed equivalent cumulative probability of success at two years of 69.9% [(45.9%–84.9%)] for AADI vs 66.8% [(53.4%–77.1%])) for the AGV, respectively. Twenty-four eyes in the AGV group needed one or more subsequent surgeries, whereas 13 eyes needed one or more surgery in the AADI group.ConclusionsThis study shows an acceptable safety profile for the AADI in children, with a rate of failure that is comparable to the AGV, but less need for glaucoma re-operation or glaucoma medication in the first post-postoperative year.

show abstract

Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surgical outcomes of the Aurolab aqueous drainage implant (AADI) versus the Ahmed glaucoma valve for refractory paediatric glaucoma in Middle Eastern children

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Non-flow restrictive/non-valved glaucoma drainage devices are associated with higher incidence of post-operative hypotony compared to flow restrictive/valved devices. [ 1 2 ] The hypotony in non-flow restrictive devices occurs due to excess aqueous outflow after dissolution of tube ligature. This complication could be transient due to inflammation, which resolves with enhanced topical steroids therapy and the hypotony eventually resolves when the bleb capsule thickens and resists outflow.…”

mentioning

confidence: 99%

“…However, the hypotony could be persistent with serious consequences like choroidal detachment, hypotony maculopathy, cataract formation. [ 1 ] Persistent hypotony would need surgical intervention; several methods that have been tried include religature to the tube, stenting of the tube with 3-0 Nylon, Prolene, or Supramid sutures. [ 3 4 5 6 ]…”

mentioning

confidence: 99%