Comparison of the influence of selenium supplementation in organic and inorganic forms on oxidant/antioxidant balance in rat lungs

Abstract

The aim of the experiment was to compare the effect of two newly synthesised organic selenocompounds with that exerted by sodium selenite on oxidant processes in rat lungs. Total antioxidant status (TAS), activity of antioxidant enzymes -superoxide dismutase (SOD) and glutathione peroxidase (GPx), concentrations of non-enzymatic antioxidants -ascorbic acid (AA) and reduced glutathione (GSH), concentration of lipid peroxidation marker -malonyldialdehyde (MDA), as well as tissue concentrations of silicon and magnesium were determined in rats receiving different selenocompounds (inorganic selenite and organic selenosemicarbazide in a chain form -compound A and selenazoline in a ring form -compound B). TAS values were elevated in comparison with control without Se-supplementation. GPx was insignificantly increased when compared to control, mainly in the group receiving compound B. Inorganic selenite significantly increased SOD and decreased levels of AA. MDA was slightly altered in Se-supplemented animals. Silicon levels were not affected, whereas magnesium concentrations were considerably reduced in all groups receiving selenium. Compound B increased TAS to the highest degree. It did not have any impact on components of the antioxidant barrier and slightly decreased MDA. Therefore, it could be suggested that further research, including in vitro studies on cancer cell lines, may reveal new possibilities of medical applications of selenocompounds.

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

“…All these results indicate that improvement of the effectiveness of the AHT in dogs with malignant tumours requires enhancement of antioxidative capacity. Such effects may be obtained by applying additional administration of constituents contributing to antioxidative capacity such as selenium, vitamin C, and vitamin E (21,24). The analysis of time-related changes of TAC in serum of dogs from the nonmalignant group demonstrated its significant improvement after one month of the AHT.…”

How Deltamethrin Produces Oxidative Stress in Liver and Kidney

“…Glutathione peroxidases are enzymes containing selenium (Se). The activity of GPx in the cells may increase until an adequate supply of Se in the diet maximizes the enzyme activity [46]. Apparently, the metabolites od DEL (3-PBA and Br 2 CA) do not pose a great risk to kidney functioning as creatinine concentrations in the blood sera were not elevated.…”

“…The ROS can damage DNA, proteins, and lipids, and change a cell's metabolism, and affect gene expression and post-translational modifications of proteins, which accelerates ageing, neurodegeneration, and development of atherosclerosis, hypertension, type II diabetes, and cancer [26,27]. Superoxide dismuthase (SOD) and glutathione peroxidase (GPx) are antioxidant enzymes ubiquitous in living organisms acting as an endogenous defense against ROS [28,29].…”

Effect of 28-Day Exposure to Fenpropathrin on the Activities of Serum Alanine Transaminase and Liver Antioxidant Enzymes in Mice

“…Even an application of antioxidants such as ascorbic acid or tocopherol did not protect yeast cells from the toxicity of the used PYRs (13). However, Musik et al (17) have shown that organic selenium compounds supplementation improved the oxidant/antioxidant balance in rats. The GPx are enzymes containing selenium.…”