Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs

Jia, Yongxing; Peng, Yalin; Zhao, Yiping; Cheng, Xi-Fei; Zhou, You; Chai, Chun-Li; Zeng, Lingshu; Pan, Min‐Hui; Xu, Li

doi:10.1021/acs.jafc.8b07245

Cited by 19 publications

(18 citation statements)

References 38 publications

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“…The compound decreased the activities of ALT and AST and suppressed the levels of enzymes and products caused by oxidative stress, as well as the expressions of several inflammatory mediators. The mechanisms involved the downregulation of the Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling and the activation of the Kelch-like ECH-associated protein 1(Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway [ 207 , 208 ].…”

Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Likhitwitayawuid

2021

Molecules

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Oxyresveratrol has recently attracted much research attention due to its simple chemical structure and diverse therapeutic potentials. Previous reviews describe the chemistry and biological activities of this phytoalexin, but additional coverage and greater accessibility are still needed. The current review provides a more comprehensive summary, covering research from 1955 to the present year. Oxyresveratrol occurs in both gymnosperms and angiosperms. However, it has never been reported in plants in the subclass Sympetalae, and this point might be of both chemotaxonomic and biosynthetic importance. Oxyresveratrol can be easily obtained from plant materials by conventional methods, and several systems for both qualitative and quantitative analysis of oxyresveratrol contents in plant materials and plant products are available. Oxyresveratrol possesses diverse biological and pharmacological activities such as the inhibition of tyrosinase and melanogenesis, antioxidant and anti-inflammatory activities, and protective effects against neurological disorders and digestive ailments. However, the unfavorable pharmacokinetic properties of oxyresveratrol, including low water solubility and poor oral availability and stability, have posed challenges to its development as a useful therapeutic agent. Recently, several delivery systems have emerged, with promising outcomes that may improve chances for the clinical study of oxyresveratrol.

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Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Likhitwitayawuid

2021

Molecules

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“…There are also a range of in vivo studies confirming that various plant-derived compounds, mainly polyphenols, decrease NF-κB and increase Nrf2 activity/expression in various model systems. These include peiminine [127], hesperetin [128], oxyresveratrol, resveratrol and mulberroside [129], salvianolic acid A [130], naringenin [131], δamyrone [132], chrysin, luteolin, apigenin, hesperetin and 3 , 4 -dimethoxy hesperetin [133], luteoloside [134], alpinetin [135], amygdalin [136], rosmarinic acid [137], chiisanoside [138], arbutin [139], and chicoric acid [140]. Moreover, the different direction of activation of Nrf2 and NF-κB was also shown to be a result of exposure to various toxic compounds.…”

Section: Mechanisms Of Nrf2-nf-κb Interactions Referencesmentioning

confidence: 99%

Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

2021

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Redox biology is a very quickly developing area of modern biological sciences, and roles of redox homeostasis in health and disease have recently received tremendous attention. There are a range of redox pairs in the cells/tissues responsible for redox homeostasis maintenance/regulation. In general, all redox elements are interconnected and regulated by various means, including antioxidant and vitagene networks. The redox status is responsible for maintenance of cell signaling and cell stress adaptation. Physiological roles of redox homeostasis maintenance in avian species, including poultry, have received limited attention and are poorly characterized. However, for the last 5 years, this topic attracted much attention, and a range of publications covered some related aspects. In fact, transcription factor Nrf2 was shown to be a master regulator of antioxidant defenses via activation of various vitagenes and other protective molecules to maintain redox homeostasis in cells/tissues. It was shown that Nrf2 is closely related to another transcription factor, namely, NF-κB, responsible for control of inflammation; however, its roles in poultry have not yet been characterized. Therefore, the aim of this review is to describe a current view on NF-κB functioning in poultry with a specific emphasis to its nutritional modulation under various stress conditions. In particular, on the one hand, it has been shown that, in many stress conditions in poultry, NF-κB activation can lead to increased synthesis of proinflammatory cytokines leading to systemic inflammation. On the other hand, there are a range of nutrients/supplements that can downregulate NF-κB and decrease the negative consequences of stress-related disturbances in redox homeostasis. In general, vitagene–NF-κB interactions in relation to redox balance homeostasis, immunity, and gut health in poultry production await further research.

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“…It suppresses oxidative stress damage by enhancing the activity of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPH-Px), and ameliorates the defects of TJ barriers in colitis animals and hydrogen peroxide (H 2 O 2 )stimulated intestinal epithelial cells (Martin et al, 2004;Mayangsari & Suzuki, 2018;Zhuang et al, 2019). Similarly, mulberroside A and its metabolites have anti-oxidative properties in protecting against lipopolysaccharide/d-galactosamine-induced liver injury in mice (Jia et al, 2019). Moreover mulberroside A exhibits neuroprotective effects in transient brain ischemia of rodents (Andrabi et al, 2004;Aziz et al, 2019;Wang et al, 2014) and ethanol-induced brain injury of mice (Wu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Mulberroside A repairs high fructose diet‐induced damage of intestinal epithelial and blood–brain barriers in mice: A potential for preventing hippocampal neuroinflammatory injury

Rao

Wen

Wang

et al. 2020

Journal of Neurochemistry

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Our previous studies showed that high fructose diet (HFrD)‐driven gut dysbiosis caused fecal short‐chain fatty acids (SCFAs) reduction and intestinal epithelial barrier (IEB) damage in mice, which might play an important role in hippocampal neuroinflammatory injury. Mulberroside A is reported to have neuroprotective effects in animal experiments, while the underlying mechanisms are not yet fully elucidated. Here, we investigated whether and how mulberroside A prevented HFrD‐induced neuroinflammatory injury. HFrD‐fed mice were treated orally with mulberroside A (20 and 40 mg/kg) for 8 weeks. Mulberroside A was found to inhibit hippocampal neuroinflammation and neurogenesis reduction in HFrD‐fed mice. It reshaped gut dysbiosis, increased fecal and serum SCFAs contents, reactivated signaling of the colonic NLR family, pyrin domain containing 6 (NLRP6) inflammasome, and up‐regulated Muc2 expression to prevent IEB damage, as well as subsequently, reduced serum endotoxin levels in this animal model. Additionally, mulberroside A inhibited oxidative stress in colon of HFrD‐fed mice and hydrogen peroxide (H2O2)‐stimulated Caco‐2 cells. Blood–brain barrier (BBB) structure defects were also observed in HFrD‐driven hippocampal neuroinflammatory injury of mice. Interestingly, mulberroside A maintained astrocyte morphology and up‐regulated tight junction proteins to repair BBB structure defects in hippocampus dentate gyrus (DG). Our results demonstrated that mulberroside A was capable of preventing HFrD‐induced damage of IEB and BBB in mice, which might contribute to the suppression of hippocampal neuroinflammatory injury.

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Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs

Cited by 19 publications

References 38 publications

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

Mulberroside A repairs high fructose diet‐induced damage of intestinal epithelial and blood–brain barriers in mice: A potential for preventing hippocampal neuroinflammatory injury

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