Comparison of the frequency of dental caries in asthmatic children under treatment with inhaled corticosteroids and healthy children in Sabzevar in 2017-2018

Hassanpour, Kazem; Tehrani, Human; Goudarzian, Maryam; Beihaghi, Sarah; Ebrahimi, Mina; Amiri, Parvin

doi:10.29333/ejgm/93478

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…Yet, salivary flow reduction and dry mouth are some of the side effects related to the use of inhaled drugs (Smidt et al, 2010). Studies have been demonstrating lack of consistency in the use of inhaled corticoid and its relation with dental caries especially in asthmatic patients, but Hassanpour et al (2019) found a higher mean of dmft in asthmatic patients than healthy group (p < 0.05) (Hassanpour et al, 2019;Mohamed et al, 2015). This result supports the finding of our work, which demonstrated that patients with AD that used inhaled corticoid were 6.4 times (OR = 6.41; p = 0.003, 95% CI: 1.88-21.08) more likely to have caries than patients that did not use inhaled corticoid.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Clinical oral profile of pediatric patients with atopic dermatitis: A cross‐sectional study

et al. 2020

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Objectives: This work aims to describe oral health conditions, eating habits, and oral hygiene in pediatric and adolescent patients with atopic dermatitis and correlate them with the severity of the Scoring Atopic Dermatitis (SCORAD). Also, we aim to estimate the effect of several variables on the diagnosis of dental caries in these patients. Material and Methods:A total of 92 children and adolescents with atopic dermatitis had their oral cavities examined. The effect of independent variables on the diagnosis of dental caries (outcome) was assessed using multiple binary logistic regression model. Results:Mild patients presented higher score of decayed, missing, and filled teeth in permanent dentition than moderate patients (p = 0.040). In the multivariable regression final model, the covariates using inhaled corticoid (OR = 6.4; p = 0.003), type of teething [deciduous dentition (OR = 7.9; p = 0.027) and mixed dentition (OR = 10.5; p = 0.007)], and brushing quality [poor mechanical control (OR = 10.6; p < 0.0001)] demonstrated significant direct effect on the diagnosis of dental caries. Conclusions:Our findings suggest that the presence of dental biofilm, use of inhaled corticoid, and type of teething are related to the presence of caries in atopic dermatitis patients. K E Y W O R D S adolescent, atopic dermatitis, children, mouth, oral health | 1835 SODRÉ et al. | INTRODUC TI ONPediatric patients with chronic diseases generally have a higher risk for the development of oral commitment, which may be related to the pathological mechanism of the disease itself or even to the implemented therapy (Turkistani et al., 2010). Among the diseases that most affect individuals since early childhood, there are topic disorders, like dental caries and atopic dermatitis (Bagramian et al., 2009;Thomsen, 2015;Williams et al., 2008). Due to its chronic feature, atopic dermatitis (AD) has numerous factors that are complexly interrelated, such as skin barrier dysfunction, genetic predisposition, immunological and environmental abnormalities, in addition to the participation of infectious agents, and psychological, nutritional, and pharmacological factors (Akdis et al., 2006;Nutten, 2015). Furthermore, AD is known to be linked to changes in the skin microbiome (dysbiosis) that is evidenced by the lower bacterial diversity, which is characterized by enrichment of Staphylococcus aureus and Staphylococcus epidermidis and depletion of Propionobacterium (Bjerre et al., 2017). This colonization by S. aureus demonstrates a relationship with the severity of the disease and consequently susceptibility to infections (Abad et al., 2020;Bjerre et al., 2017). The severity of AD can be classified by SCORAD or the "Scoring atopic dermatitis" index, which is based on the extension and intensity parameters of the lesions and subjective symptoms such as sleep and pruritus (Hanifin & Hajka, 1980). Patients with AD, especially the severe ones, tend to develop comorbidities like atopic conditions such as asthma, allergic rhinitis, and food allergies (NIAI...

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Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Clinical oral profile of pediatric patients with atopic dermatitis: A cross‐sectional study

et al. 2020

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“…У детей 9-12 лет, страдающих БА, распространенность кариозного процесса наиболее выражена при тяжелой степени заболевания [17]. Тяжесть кариеса зубов и заболеваний пародонта находится в прямой зависимости от степени тяжести БА и АтД [18][19][20][21]. Исследования показали, что распространенность кариеса у детей и подростков с аллергической патологией достигает 90-100% [22,23].…”

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Characteristics of Oral Cavity Microflora in Children with Bronchial Asthma and Atopic Dermatitis

Popova¹,

Алеманова²,

Vivtanenko³

et al. 2019

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<p>Oral Prevalence of <em>Candida</em> Species in Patients Undergoing Systemic Glucocorticoid Therapy and the Antifungal Sensitivity of the Isolates</p>

Xiao

Hoog

et al. 2020

IDR

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Background Candida species are commonly detected as colonizers of the oral cavity; candidiasis or candidemia can develop in patients who are immunocompromised. Use of topical or inhaled glucocorticoids can alter the spectrum of Candida species and can promote oral candidiasis. The present study aims to evaluate the diversity of Candida species in the oral cavity and their susceptibility to antifungal agents in patients undergoing treatment with systemic glucocorticoids (SGCs) compared with non-users. Methods We conducted a descriptive, analytical, cross-sectional study that enrolled 120 patients with oral problems who were undergoing treatment with SGCs and who were admitted to the hospital of the First Affiliated Hospital, College of Medicine, Zhejiang University and Zhejiang Hospital, Hangzhou, China, between February 2019 and September 2019. One hundred and twenty age-and sex-matched patients were recruited as the SGC non-user control group. Demographic data included oral complaints and underlying diseases; symptoms of oral candidiasis were identified on physical examination. Candida species were collected using a concentrated oral rinse. Identification of fungal isolates was based on conventional phenotypic methods assisted by DNA sequence analysis of the internal transcribed spacer (ITS) rDNA gene region. Antifungal activities of anidulafungin, amphotericin B, micafungin, caspofungin, 5-flucytosine, posaconazole, voriconazole, itraconazole, and fluconazole were evaluated using the Sensititre YeastOne TM YO10 panel supplemented by the CLSI-M27-A3 protocol. Results Fifty-two (43.33%) out of the 120 patients undergoing with SGCs were diagnosed with oral candidiasis, compared with 14 (11.67%) of the non-users ( P < 0.05). Likewise, we collected 88 strains from 73.33% of the SGC users compared with only 48 (40%) from non-users ( P < 0.05). Candida albicans was detected most frequently in both groups (45.45% vs 66.67%, respectively; P = 0.033); the overall frequency of non- Candida albicans (NCA) strains isolated from patients treated with SGCs were significantly higher than that identified among non-users (51.14% vs 33.33%, respectively; P = 0.046), although there were no significant differences concerning any single species of NCA. Resistance of C. albicans to itraconazole ( P = 0.004) and fluconazole ( P = 0.001) was significantly higher in patients treated with SGCs than in non-users; however, echinocandins, amphotericin B, voriconazole, and posaconazole were all active against strains from both participant groups with no significant differences detected. Conclusion ...

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Comparison of the frequency of dental caries in asthmatic children under treatment with inhaled corticosteroids and healthy children in Sabzevar in 2017-2018

Cited by 6 publications

References 18 publications

Clinical oral profile of pediatric patients with atopic dermatitis: A cross‐sectional study

Clinical oral profile of pediatric patients with atopic dermatitis: A cross‐sectional study

Characteristics of Oral Cavity Microflora in Children with Bronchial Asthma and Atopic Dermatitis

<p>Oral Prevalence of <em>Candida</em> Species in Patients Undergoing Systemic Glucocorticoid Therapy and the Antifungal Sensitivity of the Isolates</p>

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