Comparison of the Formula of PSA, Age, Prostate Volume and Race Versus PSA Density and the Detection of Primary Malignant Circulating Prostate Cells in Predicting a Positive Initial Prostate Biopsy in Chilean Men with Suspicion of Prostate Cancer

Murray, Nigel P; Reyes, Eduardo; Fuentealba, Cynthia; Orellana, Nelson; Morales, F. Javier

doi:10.7314/apjcp.2015.16.13.5365

Cited by 3 publications

(5 citation statements)

References 29 publications

(22 reference statements)

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“…These results were in parallel with the former two studies. 18 19 However, while predicting high-grade PCa, we did not observe difference among PSA, PSAD, and PSA-AV in our study. This might attribute to PSA per tumor volume decreases with increasing tumor grade according to a recent study.…”

Section: Discussioncontrasting

confidence: 81%

“…The predictive performance in the current study was better than that of all previous studies; thus, we recommend a PSA-AV cutoff of 400 in Chinese population. 18 19 20 …”

Section: Discussionmentioning

confidence: 99%

“…Later, in one study, the predictive effect of PSA-AV was similar to PSA density (PSAD) and another study showed that the predictive effect for a PSA-AV score of 700 was similar to a PSA cutoff of 4.0 ng ml −1 . 19 20 …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population

Zhang

et al. 2018

Asian J Androl

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This study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population. A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current study. The PSA-AV scores were calculated and assessed together with PSA and PSA density (PSAD) retrospectively. Among 2133 patients included in the analysis, 947 (44.4%) were diagnosed with PCa. The mean age, PSA, and positive rates of digital rectal examination result and transrectal ultrasound result were statistically higher in men diagnosed with PCa (all P < 0.05). The values of area under the receiver operating characteristic curves (AUCs) of PSAD and PSA-AV were 0.864 and 0.851, respectively, in predicting PCa in the entire population, both performed better than PSA (AUC = 0.805; P < 0.05). The superiority of PSAD and PSA-AV was more obvious in subgroup with PSA ranging from 2.0 ng ml−1 to 20.0 ng ml−1. A PSA-AV score of 400 had a sensitivity and specificity of 93.7% and 40.0%, respectively. In conclusion, the PSA-AV score performed equally with PSAD and was better than PSA in predicting PCa. This indicated that PSA-AV score could be a useful tool for predicting PCa in Chinese population.

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Section: Discussioncontrasting

confidence: 81%

“…The predictive performance in the current study was better than that of all previous studies; thus, we recommend a PSA-AV cutoff of 400 in Chinese population. 18 19 20 …”

Section: Discussionmentioning

confidence: 99%

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Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population

Zhang

et al. 2018

Asian J Androl

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“…Subgroups were set in Group 1 by considering region, PSA levels, age, prostate volume, method and tumor localization based on the results of meta-regression and clinical perspectives. Total serum PSA, prostate volume and age have been found to be clinically significant predictors of positive biopsy findings [45]. Within the subgroup of PSA level >=10 ng/ml and region of Asia, the pooled sensitivity was 0.65, 0.83 and specificity 0.82, 0.80.…”

Section: Varmentioning

confidence: 99%

Real-Time Elastography in the diagnosis of prostate cancer: a systematic review

Zhang

Meng

et al. 2019

Med Ultrason

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Aim: To evaluate the diagnostic accuracy of real-time elastography as a method for detecting prostate cancer.Material and methods: Relevant studies applying real-time elastography as the diagnostic modality and biopsy as the reference standard, published by March 1, 2018 were retrieved from PubMed, EMBASE, Web of Science and Cochrane Library databases. Two independent reviewers inspected all these articles to confirm the matching of the inclusion criteria. One reviewer with methodological expertise extracted the data from the included studies. Sensitivity, specificity and diagnostic odds ratio (DOR) were used to obtain overall estimates. Randomized effect method, meta-regression and subgroup analysis were performed.Results: Twenty-four studies out of 1156 identified articles met the inclusion criteria. Three groups were set: analysisby patient (Group 1), by core (Group 2), and by image (Group 3) and subgroups set in Group 1. The pooled estimate ofreal-time elastography sensitivity/ specificity/ DOR calculated with the identical P-value 0.00. Within subgroups “Asia” and“PSA>=10 ng/ml”, the pooled sensitivity, specificity and DOR were 0.83, 0.65 (p=0.01, I2=73.40%; p=0.02, I2=69.5%), 0.80, 0.82 (p=0.66, I2=0.00%; p=0.58, I2=0.00%) and 20.2, 8.67 (p=0.09, I2=54.2%; p=0.20, I2=35.5%), respectively. In these three groups, the areas under the SROC curve were 0.7417, 0.9246, and 0.6213 independently.Conclusions: Real-time elastography is a promising, reliable modality for the non-invasive diagnosis of patients with prostate cancer. The diagnostic accuracy of real-time elastography correlates tightly to the presence of higher PSA level and may help avoid unnecessary biopsy. It seems to be a useful tool in systemic biopsy.

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“…[93] The same group compared this method of CPC detection with PSA kinetics, age-defined PSA cut-off values, and the Montreal nomogram, and reported that CPC detection was superior in predicting prostate cancer at first biopsy. [94][95][96] They also concluded that men with lowgrade small volume tumors, those complying with the criteria for active observation, were CPC negative. [97] Men with benign prostatic disease, especially prostatitis, may have PSA-positive circulating tumor cells detected but they were P504S negative.…”

Section: In the Detection Of Prostate Cancermentioning

confidence: 99%

The significance and clinical utility of the detection of primary malignant circulating prostate cells: a review of the evidence

Murray¹

2016

JCMT

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Primary malignant circulating prostate cells (CPCs) are those detected in blood before definitive treatment for prostate cancer. CPCs can be detected in men with benign prostate disease; however, some methods to distinguish between benign and malignant prostate cells have to be validated. This study presents a review of the subject, including theoretical considerations for the selection of markers to detect them, the different methods used, and the utility of their detection in identifying men with prostate cancer and as a prognostic factor.

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Comparison of the Formula of PSA, Age, Prostate Volume and Race Versus PSA Density and the Detection of Primary Malignant Circulating Prostate Cells in Predicting a Positive Initial Prostate Biopsy in Chilean Men with Suspicion of Prostate Cancer

Cited by 3 publications

References 29 publications

Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population

Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population

Real-Time Elastography in the diagnosis of prostate cancer: a systematic review

The significance and clinical utility of the detection of primary malignant circulating prostate cells: a review of the evidence

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