Comparison of the Fertility Rates of Intra-Cytoplasmic Sperm Injections between Treated Endometriosis and Healthy Women

Abstract

Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis [2] High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners [3] Laparoscopic colorectal resections with transvaginal specimen extraction for severe endometriosis [4] SEndometriosis and infertility: A committee opinion [5] Effect of endometriosis on IVF/ICSI outcome: Stage III/ IV endometriosis worsens cumulative pregnancy and live-born rates [6] Possible effects of endometriosis-related immune events on reproductive function [7] Endometriosis and infertility [8] Treatment of endometriosis as a priority before art [9] Efficacy analysis of an experience on development of the combination therapy protocol for endometriosis management [10] Endometriosis management; A survey on medical & laparoscopic treatment [11] The impact of endometrioma on IVF/ICSI outcomes: A systematic review and meta-analysis [12] Effects of ovarian endometrioma on embryo quality [13] Evidence linked treatment for endometriosis-associated infertility [14] Assessment of oocyte quality in polycystic ovarian syndrome and endometriosis by spindle imaging and reactive oxygen species levels in follicular fluid and its relationship with IVF-ET outcome Aims The women with infertility caused by endometriosis, need to use assisted reproductive technology after their treatment. The objective of this study was to evaluate fertility rate using ICSI in women with treated endometriosis compared to healthy women. Materials & Methods In this retrospective quasi-experimental study, endometriotic women (n=150) who were treated by endometriosis treatment protocol of Sarem Women's hospital were selected and their fertility rate was compared with that of normal women (n=150) who referred Sarem Women's hospital for ICSI due to obstructive azoospermia of their husbands. The data were analyzed by Spearman rank correlation coefficient, Mann-Whitney U, Fisher's exact and Chi-square tests using SPSS 22 software. Findings The mature oocytes number of case group was significantly lower than control group (p=0.036); however, the fertility rate did not show significant differences between groups (p=0.397). There was a reverse significant correlation between the grade of endometriosis with the total oocyte and mature oocyte counts in endometriotic patients after treatment (p=0.04 and p=0.016, respectively). Conclusion The fertility rate using ICSI method in women after endometriosis treatment is not different from healthy women.