Comparison of the efficacy of metoprolol and carvedilol for preventing atrial fibrillation after coronary bypass surgery

Use of vitamins C and E as a prophylactic therapy to prevent postoperative atrial fibrillation

“…However, in those clinical trials, POAF incidence in the different carvedilol treated groups fluctuated between 8% and 16%, exceeding vitamin C results [105][106][107]. However, a comparative carvedilol-ascorbate trial could determine the real effects of these pharmacological agents (used separately or together) in preventing POAF.…”

Postoperative oral amiodarone versus oral bisoprolol as prophylaxis against atrial fibrillation after coronary artery bypass graft surgery: A prospective randomized trial

“…Potential reasons for this disparity could be that previous trials included a significant proportion of patients undergoing surgery for valvular heart disease (N 50% of the patients), with a lower proportion of patients placed on beta blockers (b 50% of the patients) and differences in dosing strategies that might have influenced the outcomes. Furthermore, propranolol, metoprolol and bisoprolol may not have the same efficacy for reducing post CABG AF: Acikel et al have found that carvedilol is more effective then metoprolol in these settings [23]. Hence, this study might offer an advantage in comparison with previous studies, since all subjects included in this trial are coronary patients and most of them (80%) were placed preoperatively on beta blockers.…”

The influence of preoperative pharmacotherapy on the appearance of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting

“…Acikel et al randomized 110 patients scheduled for elective CABG to receive either metoprolol (50 mg td) or carvedilol (12, 5 mg td). 37 Therapy was started 3 days prior to surgery and continued in the postoperative period with mean dosages of carvedilol (13 mg daily) and metorpolol (58 mg/day) in corresponding groups. POAF had an incidence of 36.4% in metorpolol compared to 16% in carvedilol group (p = 0.029).…”