Comparison of the efficacy and safety of a picosecond alexandrite laser and a Q-switched alexandrite laser for the treatment of freckles in Chinese patients

Yang, Yin; Lin, Peng; Ge, Yiping; Lin, Tong

doi:10.1016/j.jaad.2018.07.047

Cited by 16 publications

(23 citation statements)

References 2 publications

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“…However, these treatments usually result in oozing, bleeding, long periods of erythema and edema, crusting, and post‐inflammatory hyperpigmentation (PIH), which may cause discomfort and hinder a patient's ability to perform daily activities. The picosecond laser is a ground‐breaking innovation that can be used not only for the treatment of various pigmentary conditions but also for improving skin texture and dyspigmentation, thereby obtaining a unique rejuvenation effect . Rather than harnessing the principles of selective photothermolysis, picosecond lasers create zones of photomechanical (photoacoustic) trauma.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Safety and Efficacy of a Picosecond Alexandrite Laser With DLA for Acne Scars in Chinese Patients

Zhang

Fang

et al. 2019

Lasers Surg Med

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Background and Objectives: Recently, picosecond laser treatment has been used as an effective treatment for acne scars. To evaluate the efficacy and safety of a picosecond alexandrite laser with a diffractive lens array in the treatment of acne scars in Chinese patients. Study Design/Materials and Methods: Patients with facial acne scars were treated with a picosecond alexandrite laser in three sessions at 4-to 6-week intervals and followed up for 2 months. Primary outcomes were measured by physicians' blinded evaluation of the acne scar using the ECCA (échelle d'éva physicians'luation clinique des cicatrices d'acné) grading scale. The secondary outcomes included the investigator global assessment (IGA) on the improvement of post-inflammatory erythema (PIE), patients' assessment of improvement on a 4-point scale and of satisfaction on a 5-point scale. Pain scores and adverse effects were also evaluated. Result: Twenty patients with Fitzpatrick skin types III and IV were enrolled in the study and completed all treatment and follow-up visits. The mean ECCA scores fell from 197.75 ± 35.26 to 142.00 ± 35.92 (a 28% improvement), and the change was significant (P = 0.000). The mean IGA score of PIE improvement was 3.03 ± 0.75 (0 = no improvement and 4 = 76-100% improvement). On the basis of the patients' self-assessment, the average improvement scores were 2.30 ± 0.98 (0 indicating 0-25% improvement and 3 indicating >75% improvement). In total, 50% and 30% of the patients were "satisfied" and "very satisfied," respectively, with the treatment. The mean pain score was 3.20 ± 0.50 (0 = no pain, 10 = maximum pain) with topical anesthesia. The adverse effects included transient and mild erythema, edema, and scabbing. Conclusions: Treatment with a picosecond alexandrite laser with a diffractive lens array is effective and safe for acne scars in Chinese patients. Lasers Surg. Med.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Safety and Efficacy of a Picosecond Alexandrite Laser With DLA for Acne Scars in Chinese Patients

Zhang

Fang

et al. 2019

Lasers Surg Med

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“…Several studies have demonstrated a variety of PS lasers (e.g., 532, 755, 785, and 1064 nm) to be safe and efficacious in treating discrete benign pigmented lesions such as solar lentigines, freckles, café au lait macules, flat and raised epidermal lesions, Becker's nevi, nevus spilus, nevus of Ota and Hori's macules, and verrucous epidermal nevi [6,9,16–32]. Previously, nanosecond lasers have been associated with a relatively high risk of PIH with reports ranging from 25% to 47% [].…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of a Novel 730 nm Picosecond Titanium Sapphire Laser for the Treatment of Benign Pigmented Lesions

Lipp

Angra

2020

Lasers Surg Med

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Background and Objectives Picosecond lasers in dermatology were originally focused on optimizing the removal of unwanted tattoos. Subsequent advances in this technology have expanded its clinical indications to include treatment of benign pigmented lesions, photodamage, melasma, and scar revision. In this retrospective review, we evaluate a novel 730 nm picosecond titanium sapphire laser in treating benign pigmented lesions. Study Design/Materials and Methods This is a retrospective review of all patients who presented to our institution between December 2019 and March 2020 for treatment of their benign pigmented lesions with a 730 nm picosecond titanium sapphire laser. All Fitzpatrick skin types (I–VI) were included. Absolute and relative evaluations were conducted by two blinded board‐certified dermatologists using high‐resolution photographic images. Results Twenty‐two of 64 patients satisfied inclusion and exclusion criteria. Patients received 1.1 ± 0.3 treatment sessions. The absolute average pigmentation score prior to treatment was 2.04 ± 0.7 versus 1.39 ± 0.6 after treatment (P < 0.05). Improvement in pigmentation was observed in 86% of the patients, while 3% had no improvement and 11% had worsening of pigmentation. No other adverse events were observed. Downtime consisted of 1–2 days of mild edema and erythema followed by 3–5 days of mild pigment darkening and superficial crust. Conclusion The novel 730 nm picosecond titanium sapphire laser is a safe and effective treatment for benign pigmented lesions. Future prospective randomized control studies would be beneficial to further clarify its role in the treatment of benign pigmentation. Lasers Surg. Med. © 2020 Wiley Periodicals LLC

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“…Treating a greater number of lesions may result in more robust data and a clearer signal. Finally, Yang et al [23] reported no differences between a picosecond and nanosecond alexandrite laser for the treatment of Chinese freckles. Both lasers performed excellently after a single treatment and a 2‐month follow‐up evaluation.…”

Section: Discrete Pigmented Lesionsmentioning

confidence: 99%

“…Picosecond lasers with wavelengths of 532, 755, and 1064 nm have been reported to be safe and effective in the treatment of a wide range of discrete pigmented lesions including solar lentigines, freckles, verrucus epidermal nevus, café au lait macules (CALM), nevus of Ota, and Hori's macules. A total of five case reports/series; five retrospective reviews; three prospective open-label trials; and four split-face/lesion randomized comparison trials involving a cumulative 320 subjects have documented these findings [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Discrete Pigmented Lesionsmentioning

confidence: 99%

“…Nevus of Ota, Hori's macules, solar lentigines in Asians, and freckles in Chinese have been the subject of picosecond versus nanosecond laser comparison trials [23,24,28,93]. Ge et al [28] conducted a randomized, double‐blind, split lesion clinical trial comparing a 750 picoseconds alexandrite laser with a 70 nanoseconds alexandrite laser for the treatment of Nevus of Ota.…”

Section: Discrete Pigmented Lesionsmentioning

confidence: 99%

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A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

et al. 2020

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Background and Objectives The use of picosecond laser in dermatology was originally focused on optimizing the removal of unwanted tattoos. Subsequent advances in this technology have broadened its clinical indications to include treatment of benign pigmented lesions, photodamage, melasma, and scar revision. In this systematic review, evidence‐based recommendations are developed for the use of picosecond laser in dermatology. Study Design/Materials and Methods A comprehensive search of the English language literature was performed up to and including November 2019. Relevant citations were individually evaluated, synthesized, and categorized based on the Level of Evidence. With the addition of the authors’ combined clinical experience, clinical recommendations were developed. Results After application of inclusion and exclusion criteria, a total of 77 unique studies were evaluated. Treatment of benign pigmented lesions was associated with level I–IV evidence; rejuvenation was associated with level II evidence; melasma was associated with level II evidence; scar revision was associated with level II–III evidence; tattoo removal was associated with level I evidence. Conclusion Picosecond laser is a safe and effective treatment modality for an increasing range of dermatologic indications. Further development of this technology is warranted. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.

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Comparison of the efficacy and safety of a picosecond alexandrite laser and a Q-switched alexandrite laser for the treatment of freckles in Chinese patients

Cited by 16 publications

References 2 publications

Evaluation of the Safety and Efficacy of a Picosecond Alexandrite Laser With DLA for Acne Scars in Chinese Patients

Evaluation of the Safety and Efficacy of a Picosecond Alexandrite Laser With DLA for Acne Scars in Chinese Patients

Safety and Efficacy of a Novel 730 nm Picosecond Titanium Sapphire Laser for the Treatment of Benign Pigmented Lesions

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

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