Comparison of the Effects on Rib Fracture between the Traditional Japanese Medicine Jidabokuippo and Nonsteroidal Anti-Inflammatory Drugs: A Randomized Controlled Trial

Abstract

Jidabokuippo is a traditional Japanese medicine used for contusion-induced swelling and pain. This open multicenter randomized study was designed to compare the efficacies of jidabokuippo and nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rib fracture by analyzing the treatment duration. Our study involved 170 rib fracture patients capable of oral ingestion divided randomly into 2 groups: the jidabokuippo and NSAID groups. We compared the duration of treatment and healthcare expenditure between these 2 groups. Medication was continued in both groups until the visual analogue scale score decreased to less than 50% of the pretreatment score. We excluded the patients in whom medication was prematurely discontinued. We analyzed 81 patients belonging to the jidabokuippo and NSAIDs groups. No significant intergroup differences were observed in age, gender, severity (injury severity score), and presence/absence of underlying disease. The treatment duration was significantly shorter in the jidabokuippo group than in the NSAIDs group (P = 0.0003). Healthcare expenditure was significantly lower in the jidabokuippo group than in the NSAIDs group (P < 0.0001). Our results suggest that compared to NSAIDs, jidabokuippo can shorten the duration of treatment in patients with rib fracture and is a promising analgesic agent based on the medical economic viewpoint.

Traumatic lateral abdominal wall hematoma treated with Kampo medicines

“…Moreover, we have previously demonstrated the antioxidant activity of JDI [8,9]. We also reported that JDI could be useful not only for contusion and sprain but also for rib and extremity fractures [10,11].…”

Determination of β‐d‐glucan and endotoxin levels in Kampo extracts

“…For these reasons, it would seem difficult to apply these traditional treatment approaches in emergency medicine. Nevertheless, use of Kampo extracts is gradually increasing in clinical settings . However, it should be examined whether and how different concentrations of BDG and ETX in Kampo extracts affect patients.…”

Kampo Medicines for Frailty in Locomotor Disease

“…Kampo formulations exhibit antioxidant activity that is thought to be associated with swelling reduction ( 26 , 27 ). We compared the efficacies of JDI and NSAIDs in patients with rib fracture by analyzing the treatment duration ( 24 ). Our results suggested, that compared with NSAIDs, JDI could shorten the duration of treatment and may provide a promising analgesic agent, from a medical economic viewpoint (Figure 2 ).…”

“… Comparison of treatment durations and expenditures for medication between the jidabokuippo (JDI) and the non-steroidal anti-inflammatory drugs (NSAIDs) groups (( 24 ) revised). (A) .…”