Comparison of the effects of chronic central administration and chronic peripheral administration of islet amyloid polypeptide on food intake and meal pattern in the rat

Olsson, Mariann; Herrington, Margery K.; Reidelberger, Roger D.; Permert, Johan; Arnelo, Urban

doi:10.1016/j.peptides.2007.06.011

Cited by 35 publications

(36 citation statements)

References 43 publications

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“…Taken together, these data suggest that amylin's (and sCT) ability to reduce food intake is neither vagal afferent driven nor secondary to its inhibitory response on gastric emptying. Multiple laboratories have demonstrated that central amylin or sCT injections potently reduce food intake (2,7,21,29). A dose comparison between peripheral and central (third ventricle intracerebroventricular) chronic administration of amylin in rats revealed that the minimum effective dose at suppressing food intake was 10-fold lower when delivered intracerebroventricularly (29).…”

Section: Discussionmentioning

confidence: 99%

“…Multiple laboratories have demonstrated that central amylin or sCT injections potently reduce food intake (2,7,21,29). A dose comparison between peripheral and central (third ventricle intracerebroventricular) chronic administration of amylin in rats revealed that the minimum effective dose at suppressing food intake was 10-fold lower when delivered intracerebroventricularly (29). A relatively high density of amylin receptors are located in brain regions involved in the control of ingestive behaviors, such as the dorsal medial hypothalamus, ventromedial hypothalamus, nucleus accumbens, nucleus of the solitary tract and area postrema (4,37).…”

Section: Discussionmentioning

confidence: 99%

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Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Bello

Kemm

Moran³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Bello

Kemm

Moran³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Previous studies had shown that chronic subcutaneous or third ventricular infusion of amylin produced a transient, dose-dependent decrease in daily food intake and a decrease in body weight gain [40,41]. Mack and colleagues showed that amylin 21 (10µg/kg/day) infused subcutaneously for four weeks decreased food intake and body weight in rats fed a HF diet for five weeks [16].…”

Section: Hyperamylinemia Alone Does Not Cause Amylin Insensitivitymentioning

confidence: 99%

Influence of high-fat feeding, diet-induced obesity, and hyperamylinemia on the sensitivity to acute amylin

Boyle¹,

Rossier²,

Lutz³

2011

Physiology & Behavior

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Obesity results in the increased secretion of various hormones controlling food intake and body weight, such as leptin, and insulin; increased circulating levels of pancreatic amylin have also been described in obese humans and rodents. Because leptin-resistance is present in diet-induced obese (DIO) rats, and because hyperleptinemia seems necessary for the full development of leptin resistance, we tested whether amylin sensitivity is inversely correlated with adiposity, such that DIO reduces the anorectic action of acute amylin. We also determined if hyperamylinemia leads to a change in amylin sensitivity. In the first experiment, rats were chronically exposed to a high fat (HF; 60% fat) diet or fed standard chow for control. The anorectic response to amylin was tested on several occasions over a 14 week observation period. HF feeding led to the expected increase in body adiposity; the response to an acute amylin injection (5-50 g/kg s.c.) was unaltered for 10 weeks of HF feeding. Even after 12 weeks on a HF diet, which clearly caused obesity, acute administration of amylin (5 g/kg, s.c.) was still able to suppress food intake, although the suppression was not statistically significant. Further experiments using additional doses of amylin will be necessary to demonstrate possible amylin resistance after HF feeding or in DIO rats. In the second experiment, we tested more specifically whether hyperamylinemia that may result from HF feeding and subsequent obesity, reduces the sensitivity of the amylin signaling system. To avoid confounding factors, we chronically infused lean chow fed rats with amylin (5 or 10 g/kg/day s.c.) to elevate their plasma amylin concentration to levels observed in obese rats (30-40 pM). In the absence of obesity, hyperamylinemia did not lead to a reduced sensitivity to acute amylin (5-20 g/kg s.c.) injections; acute amylin reduced eating similarly in all groups of rats. Overall, we concluded that direct diet effects by short term exposure to HF appear to be of little importance for amylin sensitivity; further, long-term maintenance on a HF diet and the resulting obesity only slightly attenuated the anorectic response to acute amylin. Because we observed no marked changes in amylin sensitivity in lean, chow fed rats with induced hyperamylinemia, amylin receptor downregulation in chronic hyperamylinemia does not seem to occur. 1 Long-term maintenance on a HF diet only slightly attenuates acute amylin action.2 Attenuation of amylin action seems more related to obesity than HF exposure.3 Acute amylin sensitivity is not reduced by chronic hyperamylinemia.3 ABSTRACTObesity results in the increased secretion of various hormones controlling food intake and body weight, such as leptin, and insulin; increased circulating levels of pancreatic amylin have also been described in obese humans and rodents. Because leptinresistance is e.g. present in diet-induced obese (DIO) rats, and because hyperleptinemia seems necessary for the full development of leptin resistance, we tested whether amyl...

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“…Amylin easily crosses the blood-brain barrier (BBB) [1, 2] and mediates important brain functions including inhibition of appetite by acting on area postremal [3], relaxation of cerebrovascular structure [4, 5], and perhaps enhancement of neural regeneration [6]. It is co-secreted with insulin and plays an important role in regulating glucose metabolism [3].…”

Section: Introductionmentioning

confidence: 99%

Positive Association between Plasma Amylin and Cognition in a Homebound Elderly Population

Qiu

Zhu

et al. 2014

JAD

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Our recent study reported that amylin, a pancreatic peptide that readily crosses the blood-brain barrier, improves learning and memory in Alzheimer’s disease mouse models. However, the relationship between peripheral amylin and cognition in humans is unknown. In this follow-up study, using a cross-sectional, homebound elderly population, improvement in cognitive function with increasing quartiles of plasma amylin was suggested by positive association with verbal memory (p = 0.0002) and visuoconstruction tasks (p = 0.004), and inverse association with timed measures of attention (p < 0.0001) and executive function (p = 0.04). After adjusting for demographic information, apolipoprotein E4 allele, diabetes, stroke, kidney function, and lipid profile, log10 of plasma amylin remained associated with these cognitive domains. In contrast, plasma amyloid-β peptide was not associated with these specific cognitive domains. Our study suggests that peripheral amylin may be protective for cognitive decline, especially in the domains affected by Alzheimer’s disease.

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Comparison of the effects of chronic central administration and chronic peripheral administration of islet amyloid polypeptide on food intake and meal pattern in the rat

Cited by 35 publications

References 43 publications

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Influence of high-fat feeding, diet-induced obesity, and hyperamylinemia on the sensitivity to acute amylin

Positive Association between Plasma Amylin and Cognition in a Homebound Elderly Population

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