Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Bello, Nicholas T.; Kemm, Matthew; Moran, Timothy H.

doi:10.1152/ajpregu.90327.2008

Cited by 15 publications

(14 citation statements)

References 44 publications

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“…However, sCT decreased both short-term and long-term (1-and 24-hour values) food intake in high alcohol-consuming rats, which was accompanied by a decrease in body weight. The shortterm effect of sCT on food intake in the low alcohol consumers is compatible with other food intake studies, where various doses of sCT suppress food intake in a dose-dependent manner, showing the most robust effect on the first meal size (Bello et al 2008). Moreover, the present results are in accordance with previous studies that have established an anorexigenic effect of the activation of amylin receptors (Reda et al 2002).…”

Section: Discussionsupporting

confidence: 93%

“…Our data revealed that a low dose of sCT (1 μg/kg) did not block but presented a dosedependent effect in regard to alcohol-induced locomotor stimulation. Experiments in rhesus monkeys have showed that administration of lower doses of sCT, in the range of 0.032 to 1 μg/kg, decreases food intake in a dose-response manner (Bello, Kemm, & Moran 2008), suggesting a potential enhanced effect of higher doses of the drug. However, the absence of significant sCT effect in our locomotor activity experiments could potentially be explained by the requirement of higher doses of sCT in order to exert its alcohol antagonizing effects.…”

Section: Discussionmentioning

confidence: 99%

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Activation of amylin receptors attenuates alcohol‐mediated behaviours in rodents

2018

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Alcohol expresses its reinforcing properties by activating areas of the mesolimbic dopamine system, which consists of dopaminergic neurons projecting from the ventral tegmental area to the nucleus accumbens. The findings that reward induced by food and addictive drugs involve common mechanisms raise the possibility that gut-brain hormones, which control appetite, such as amylin, could be involved in reward regulation. Amylin decreases food intake, and despite its implication in the regulation of natural rewards, tenuous evidence support amylinergic mediation of artificial rewards, such as alcohol. Therefore, the present experiments were designed to investigate the effect of salmon calcitonin (sCT), an amylin receptor agonist and analogue of endogenous amylin, on various alcohol-related behaviours in rodents. We showed that acute sCT administration attenuated the established effects of alcohol on the mesolimbic dopamine system, particularly alcohol-induced locomotor stimulation and accumbal dopamine release. Using the conditioned place preference model, we demonstrated that repeated sCT administration prevented the expression of alcohol's rewarding properties and that acute sCT administration blocked the reward-dependent memory consolidation. In addition, sCT pre-treatment attenuated alcohol intake in low alcohol-consuming rats, with a more evident decrease in high alcohol consumers in the intermittent alcohol access model. Lastly, sCT did not alter peanut butter intake, blood alcohol concentration and plasma corticosterone levels in mice. Taken together, the present data support that amylin signalling is involved in the expression of alcohol reinforcement and that amylin receptor agonists could be considered for the treatment of alcohol use disorder in humans.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Activation of amylin receptors attenuates alcohol‐mediated behaviours in rodents

2018

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“…VTA knockdown of CTR-A expression was confirmed via qPCR (e). with systemic amylin's satiating properties (Bello et al, 2008;Lutz, 2005;Lutz et al, 1995b). Along with the current findings indicating a role for NAcC DA signaling in VTA amylin-mediated control of feeding, these data suggest that VTA AmyR activation may engage common physiological (DA) and behavioral (meal size) mechanisms to produce the suppression of intake of both palatable and bland foods by VTA AmyR activation.…”

Section: Discussionsupporting

confidence: 76%

“…Systemic administration of amylin and amylin agonists such as salmon calcitonin (sCT) and pramlintide reduce food intake and body weight in humans and animal models (Bello et al, 2008;Chapman et al, 2005;Lutz et al, 1994Lutz et al, , 2000Smith et al, 2007), effects mediated by the CNS (Lutz et al, 1995a;Rushing et al, 2000). Previous research has focused heavily on the notion that amylin receptor (AmyR) activation in the area postrema (AP), a hindbrain circumventricular nucleus, is responsible for amylin-induced hypophagia (Lutz et al, 1998;Mollet et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Amylin Modulates the Mesolimbic Dopamine System to Control Energy Balance

Mietlicki‐Baase

Reiner

Cone

et al. 2014

Neuropsychopharmacol

103

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Amylin acts in the CNS to reduce feeding and body weight. Recently, the ventral tegmental area (VTA), a mesolimbic nucleus important for food intake and reward, was identified as a site-of-action mediating the anorectic effects of amylin. However, the long-term physiological relevance and mechanisms mediating the intake-suppressive effects of VTA amylin receptor (AmyR) activation are unknown. Data show that the core component of the AmyR, the calcitonin receptor (CTR), is expressed on VTA dopamine (DA) neurons and that activation of VTA AmyRs reduces phasic DA in the nucleus accumbens core (NAcC). Suppression in NAcC DA mediates VTA amylin-induced hypophagia, as combined NAcC D1/D2 receptor agonists block the intake-suppressive effects of VTA AmyR activation. Knockdown of VTA CTR via adeno-associated virus short hairpin RNA resulted in hyperphagia and exacerbated body weight gain in rats maintained on high-fat diet. Collectively, these findings show that VTA AmyR signaling controls energy balance by modulating mesolimbic DA signaling.

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“…Meal pattern analyses revealed that this effect was mainly due to suppression of meal size, rather than changes to meal frequency, an effect that is consistent with the mechanism of intake suppression produced by peripherally administered amylin receptor agonists (Bello et al, 2008;Lutz et al, 1995b). Thus, it is logical that VTA amylin receptor signaling may control for food intake by modulating the rewarding value of the ongoing meal while having fewer effects on satiety (inter-meal processes).…”

Section: Discussionsupporting

confidence: 55%

Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake

Mietlicki‐Baase

Rupprecht

Olivos

et al. 2013

Neuropsychopharmacol

116

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The ability of amylin, a pancreatic b-cell-derived neuropeptide, to promote negative energy balance has been ascribed to neural activation at the area postrema. However, despite amylin binding throughout the brain, the possible role of amylin signaling at other nuclei in the control of food intake has been largely neglected. We show that mRNA for all components of the amylin receptor complex is expressed in the ventral tegmental area (VTA), a mesolimbic structure mediating food intake and reward. Direct activation of VTA amylin receptors reduces the intake of chow and palatable sucrose solution in rats. This effect is mediated by reductions in meal size and is not due to nausea/malaise or prolonged suppression of locomotor activity. VTA amylin receptor activation also reduces sucrose selfadministration on a progressive ratio schedule. Finally, antagonist studies provide novel evidence that VTA amylin receptor blockade increases food intake and attenuates the intake-suppressive effects of a peripherally administered amylin analog, suggesting that amylin receptor signaling in the VTA is physiologically relevant for food intake control and potentially clinically relevant for the treatment of obesity.

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Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Abstract: Bello NT, Kemm MH, Moran TH. Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys.

Cited by 15 publications

References 44 publications

Activation of amylin receptors attenuates alcohol‐mediated behaviours in rodents

Activation of amylin receptors attenuates alcohol‐mediated behaviours in rodents

Amylin Modulates the Mesolimbic Dopamine System to Control Energy Balance

Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake

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