Comparison of the effects of epidural or intravenous methadone on the minimum alveolar concentration of isoflurane in dogs

Campagnol, Daniela; Neto, Francisco José Teixeira; Peccinini, Rosângela Gonçalves; Oliveira, F. A.; Alvaides, Renata K.; Medeiros, Luíza Quintão

doi:10.1016/j.tvjl.2011.08.019

Cited by 25 publications

(29 citation statements)

References 17 publications

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“…It has been suggested that the administration of non-steroidal anti-inflammatory drugs (NSAIDs), opioids, or local anaesthetics prior to injury reduces central sensitisation, analgesic consumption, and the use of rescue analgesia [10,11]. Opioids are commonly used for sedation and the treatment of postoperative pain in small animals [4,12-14]. Although it is well known that they may cause immune suppression in humans by helping to control the release of inflammatory substances [15-17], there is little information regarding opioid action on the canine immune system.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of methadone and tramadol on postoperative analgesia and serum interleukin-6 in dogs undergoing orthopaedic surgery

et al. 2014

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BackgroundAcute postsurgical pain is of great interest due to potential risk of becoming chronic if not treated properly, worsening patient’s recovery and quality of life. Twenty-eight dogs with ruptured cruciate ligaments were divided into three groups that received intramuscular injections of 4 mg/kg of tramadol (TRA), 0.5 mg/kg of methadone (MET0.5), or 0.7 mg/kg of methadone (MET0.7). Physiological parameters (heart and respiratory rates and blood pressure) were evaluated at specified times: baseline (TBL), 1 (T1), 2 (T2), 4 (T4), 6 (T6), and 24 (T24) hours after premedication. Pain scores were described by visual analogue scale (VAS), modified Glasgow Composite, and Colorado University Acute Pain scales. Blood samples for measurement of interleukin (IL)-6 were collected at TBL, T1, T6, and T24. This was a prospective, randomised investigation to evaluate the efficacy of tramadol and methadone as premedications in dogs undergoing osteotomies.ResultsThere were no statistically significant differences between groups with respect to age, weight, gender, surgery time, and time to extubation. Heart rate, respiratory rate, and blood pressure values were maintained within acceptable ranges, and a reduction was observed at T2 in MET0.5 and MET0.7 compared with TBL. Increases in VAS scores were observed in TRA at T4 compared with TBL, T1, and T24 and between T1 and T6 (p < 0.001). In MET0.5, there was significant increase in VAS score at T4 compared with T1 (p < 0.001). TRA and MET0.5 showed significantly higher mean ± SD VAS scores (3.4 ± 2.5 and 2.5 ± 2.6, respectively) than MET0.7 (1.1 ± 1.5) at T4 (p < 0.001). TRA showed greater demand of rescue analgesia (four animals in T4 and two in T6) (p < 0.037). There were no statistically significant differences in sedation scores, Colorado Scale scores, or interleukin levels between groups and time points.ConclusionsMethadone given as premedication in doses of 0.7 mg/kg was better at controlling pain compared with lower doses and tramadol. However, dosage increases, administered as rescue analgesia, promoted adequate pain control even in tramadol group. Influence of these analgesics on IL-6 release could not be demonstrated, but significant levels were not found.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-014-0194-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of methadone and tramadol on postoperative analgesia and serum interleukin-6 in dogs undergoing orthopaedic surgery

et al. 2014

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“…Methadone administered by the epidural route to dogs that underwent femorotibial joint surgery had analgesia duration of approximately 7.5 h based on a numerical pain scoring system 2 . These differences in the duration of analgesia may be related to the different drugs, and different subjective pain scales used in our study and those of others 2,24 . The cortisol concentration is objective for determining physiologic or neurohumoral stress response in dogs; however, routine measurement of cortisol is clinically impractical 28 .…”

Section: Discussionmentioning

confidence: 64%

“…Epidural administration of oxymorphone in combination with bupivacaine in halothane-anesthetized dogs showed decreased heart rate and blood pressure 7 . Another study showed a decrease in heart rate after epidural methadone in isoflurane-anesthetized dogs, but an increase in blood pressure (systolic arterial pressure) 24 . We did not observe any alteration in the cardiovascular system with either dose of nalbuphine epidural in the present study during the anaesthetic period.…”

Section: Discussionmentioning

confidence: 96%

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Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs

Frazílio

DeRossi²,

Jardim³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy. METHODS:Twenty four healthy female dogs were randomly assigned to receive saline or nalbuphine at 0.3 or 0.6 mg/kg (n=8 for each group) administered via lumbosacral epidural catheter introduced cranially into the epidural canal. Changes in heart and respiratory rates and arterial blood pressure during surgery were recorded along with the corresponding EtISO. Immediately after tracheal extubation, analgesia, sedation, heart rate, respiratory rate, and arterial blood pressure were measured at predetermined intervals and every 60 min thereafter until the first rescue analgesic. RESULTS:A significant decrease in EtISO was associated with epidural nalbuphine at 0.3 mg/kg (26.3%) and 0.6 mg/kg (38.4%) but not with saline in ovariohysterectomized dogs. In the postoperative period, VAS and Colorado analgesic scores were lower for the dogs that received the higher nalbuphine dose, which only required supplemental analgesia 10 h following its administration, compared with dogs that received the lower dose. CONCLUSION:Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs.

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“…Among the different techniques, epidural administration of local anaesthetics and analgesics is nowadays widely employed in canine clinical patients, especially when performing orthopedic procedures involving the hind limbs [1, 2]. Beside its clinical application, within the last decade, epidural anaesthesia has been the focus of a large number of experimental investigations [3–5]. …”

Section: Introductionmentioning

confidence: 99%

Limitations of the Use of Pressure Waves to Verify Correct Epidural Needle Position in Dogs

Adami

Bergadano²,

Spadavecchia³

2013

Veterinary Medicine International

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The use of pressure waves to confirm the correct position of the epidural needle has been described in several domestic species and proposed as a valid alternative to standard methods, namely, control radiographic exam and fluoroscopy. The object of this retrospective clinical study was to evaluate the sensitivity of the epidural pressure waves as a test to verify the correct needle placement in the epidural space in dogs, in order to determine whether this technique could be useful not only in the clinical setting but also when certain knowledge of needle's tip position is required, for instance when performing clinical research focusing on epidural anaesthesia. Of the 54 client-owned dogs undergoing elective surgeries and enrolled in this retrospective study, only 45% showed epidural pressure waves before and after epidural injection. Twenty-six percent of the animals showed epidural pressure waves only after the injection, whereas 29% of the dogs showed epidural pressure waves neither before nor after injection and were defined as false negatives. Our results show that the epidural pressure wave technique to verify epidural needle position lacks sensitivity, resulting in many false negatives. As a consequence, the applicability of this technique is limited to situations in which precise, exact knowledge of the needle's tip position is not mandatory.

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Comparison of the effects of epidural or intravenous methadone on the minimum alveolar concentration of isoflurane in dogs

Cited by 25 publications

References 17 publications

Evaluation of the effects of methadone and tramadol on postoperative analgesia and serum interleukin-6 in dogs undergoing orthopaedic surgery

Evaluation of the effects of methadone and tramadol on postoperative analgesia and serum interleukin-6 in dogs undergoing orthopaedic surgery

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs

Limitations of the Use of Pressure Waves to Verify Correct Epidural Needle Position in Dogs

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