Comparison of the effects of L-type calcium channel antagonist Amlodipine with L/N-type calcium channel antagonist Cilnidipine on blood pressure, heart rate, proteinuria and lipid profile in hypertensive patients

Abstract

Abstract:Background: Cilnidipine is a novel and unique 1,4-dydropyridine derivative calcium antagonist that exerts potent inhibitory actions not only on L-type but also on N-type voltage dependent calcium channels. Blockade of the neural N-type calcium channel inhibits the secretion of norepinephrine from peripheral neural terminals and depresses sympathetic nervous system activity. Objective and methods: The purpose of this study was to assess the effect of Cilnidipine and Amlodipine on blood pressure (BP) levels. We did BP monitoring before and after once-daily use of Cilnidipine and Amlodipine in 100 hypertensive patients. Results: Both drugs significantly reduced systolic BP (SBP) and diastolic BP (DBP). However, the reductions in pulse rate (PR) were significantly greater in the Cilnidipine group than the Amlodipine group. N-type calcium channel blockade by Cilnidipine may not cause reflex tachycardia, and may be useful for hypertensive treatment. Conclusion: There was significant reduction in proteinuria with Clindipine as compared to Amlodipine. However, there were no significant change in total cholesterol level in diabetes and non-diabetics in both the group.

Efficacy of Cilnidipine (L/N-type Calcium Channel Blocker) in Treatment of Hypertension: A Meta-Analysis of Randomized and Non-randomized Controlled Trials

“… Minami et al [ 17 ]; Sakata et al [ 18 ]; Takeda et al [ 19 ]; Rose et al [ 20 ]; Kojima et al [ 21 ]; Tsuchihashi et al [ 22 ]; Morimoto et al [ 23 ]; Fujita et al [ 24 ]; Hong et al [ 25 ]; Konoshita et al [ 26 ]; Abe et al [ 27 ]; Miwa et al [ 28 ]; Abe et al [ 29 ]; Kanoaka et al [ 30 ]; Adake et al [ 11 ]; Singh et al [ 31 ]; Pathapati et al [ 32 ]; Masaki et al [ 33 ]; Das et al [ 34 ]; Singal et al [ 35 ]; Hwang et al [ 36 ]; Oh et al [ 37 ]; Kawabata et al [ 38 ]; Fujiwara et al [ 39 ] …”

“…FIGURE 2: Forest plot for change in SBP (K=24) SBP: systolic blood pressure; REML: random-effects model; SD: standard deviation; CI: confidence intervals Minami et al [17]; Sakata et al [18]; Takeda et al [19]; Rose et al [20]; Kojima et al [21]; Tsuchihashi et al [22]; Morimoto et al [23]; Fujita et al [24]; Hong et al [25]; Konoshita et al [26]; Abe et al [27]; Miwa et al [28]; Abe et al[29]; Kanoaka et al[30]; Adake et al[11]; Singh et al[31]; Pathapati et al[32]; Masaki et al[33]; Das et al[34]; Singal et al[35]; Hwang et al[36]; Oh et al[37]; Kawabata et al[38]; Fujiwara et al[39] …”