Comparison of the effects of curcumin, tramadol and surgical treatments on neuropathic pain induced by chronic constriction injury in rat

Ceyhan, Dilek; Koçman, Atacan Emre; Yıldırım, Engin; Özatik, Orhan; Aydın, Şule; Köse, Aydan Ayşe

doi:10.5137/1019-5149.jtn.19824-17.0

Cited by 14 publications

(14 citation statements)

References 14 publications

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“…In an experimental pain study, the simultaneous oral administration of curcumin with the intraperitoneal administration of tramadol significantly attenuated mechanical allodynia and thermal hyperalgesia. 45 Curcumin's anti-nociceptive mechanism is not clear but has proved to be part of the mechanisms involved in CX3CR1 expression, Mu and Delta opioid receptors, 5-HT (1A) receptors, or TNF-α expression. 46 Curcumin was also found to attenuate the capsaicin-induced transient receptor potential of vanilloid 1 in experimental pain hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Bulboacă¹,

Bolboacă²,

Stănescu³

et al. 2018

IJN

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BackgroundCurcumin has antioxidative properties that could be useful in various diseases due to its ability to act on multiple targets of various cellular pathways. We aimed to assess the efficacy of liposomal curcumin compared with curcumin solution, when in addition to sumatriptan (ST) treatment, in an experimental migraine model induced with nitroglycerin (NTG) in rats.MethodsSeven groups of 9 rats each were investigated: control group without migraine (1 mL saline solution intraperitoneal injection [ip]), control group with induced migraine, NTG+ST group (ST), NTG+ST+curcumin1 (CC1) group – 1 mg/100 g body weight (bw), NTG+ST+CC2 – 2 mg/100 g bw, NTG+ST+liposomal curcumin1 (lCC1) group – 1 mg/100 g bw, and NTG+ST+lCC2 (lCC2) group – 2 mg/100 g bw. NTG and ST were administered as 1 mL ip NTG | 1 mg/100 g bw and 1 mL ip ST | 1 mg/100 g bw, respectively. Plasma total oxidative stress (TOS), malondialdehyde (MDA), nitric oxide (NOx), thiol levels, as well as total antioxidative capacity (TAC) were assessed. The nociception process was assessed by counting the number of flinches and shakes after the formalin test.ResultsThe plasma TOS, MDA, and NOx levels, as oxidative stress parameters, were significantly decreased in the curcumin-treated groups, especially where curcumin was in liposomal form. The thiol and TAC were also improved by the curcumin treatment, with the best results obtained for the liposomal curcumin. The closest number of flinches and shakes to the control group was obtained for the group treated with liposomal curcumin at a dose of 2 mg/100 g bw.ConclusionLiposomal curcumin in a dose of 2 mg/100 g bw when in addition to ST treatment could be an optimum therapeutic strategy for migraine attacks and could represent a base for future clinical research and application.

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Section: Discussionmentioning

confidence: 99%

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Bulboacă¹,

Bolboacă²,

Stănescu³

et al. 2018

IJN

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“…Histological analysis showed dose-dependent myelin sheath thickening with 40 mg/kg/day being the more effective in reversing damage to the nerve [ 74 ]. Rats that underwent CCI or CCI-chronic constriction release of the sciatic nerve also showed after curcumin oral treatment greater axonal regeneration and weaker degeneration of nerve tissues [ 75 ]. In hereditary neuropathy models of CMT, a 90-day curcumin treatment by oral gavage starting at postnatal day 4 in R98C CMT1B and Tremble-J mice, and i.p.…”

Section: Curcumin Studies In Animal Models Of Pnmentioning

confidence: 99%

Key Developments in the Potential of Curcumin for the Treatment of Peripheral Neuropathies

et al. 2020

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Peripheral neuropathies (PN) can be triggered after metabolic diseases, traumatic peripheral nerve injury, genetic mutations, toxic substances, and/or inflammation. PN is a major clinical problem, affecting many patients and with few effective therapeutics. Recently, interest in natural dietary compounds, such as polyphenols, in human health has led to a great deal of research, especially in PN. Curcumin is a polyphenol extracted from the root of Curcuma longa. This molecule has long been used in Asian medicine for its anti-inflammatory, antibacterial, and antioxidant properties. However, like numerous polyphenols, curcumin has a very low bioavailability and a very fast metabolism. This review addresses multiple aspects of curcumin in PN, including bioavailability issues, new formulations, observations in animal behavioral tests, electrophysiological, histological, and molecular aspects, and clinical trials published to date. The, review covers in vitro and in vivo studies, with a special focus on the molecular mechanisms of curcumin (anti-inflammatory, antioxidant, anti-endoplasmic reticulum stress (anti-ER-stress), neuroprotection, and glial protection). This review provides for the first time an overview of curcumin in the treatment of PN. Finally, because PN are associated with numerous pathologies (e.g., cancers, diabetes, addiction, inflammatory disease...), this review is likely to interest a large audience.

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“…In addition, curcumin could be used to treat various neurological disorders, such as major depression, tardive dyskinesia, Alzheimer's disease, and diabetic neuropathy, as it has neuroprotective effects [27,28]. Recent studies have also demonstrated that curcumin has an anti-nociceptive effect in treating neuropathic pain [29]. These findings suggested a prospective efficacy of curcumin on pain relieving as a natural pigment.…”

Section: Discussionmentioning

confidence: 88%

Administration of Curcumin Alleviates Neuropathic Pain in a Rat Model of Brachial Plexus Avulsion

Xie¹,

Xie²,

Kang³

et al. 2019

Pharmacology

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Background/Aims: Brachial plexus avulsion (BPA) generally causes a chronic persistent pain that lacks efficacious treatment. Curcumin has been found to possess anti-inflammatory abilities. However, little is known about the mechanisms and effects of curcumin in an animal model of BPA. Methods: Mechanical withdrawal thresholds (MWT) were examined by von Frey filaments. Cold allodynia was tested by the acetone spray test. The levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in rat spinal cords were analyzed by the enzyme-linked immunosorbent assay, and the expression levels of c-Fos and nerve growth factor (NGF) were measured by Western blot. The expression level of glial fibrillary acidic protein (GFAP) was observed by immunofluorescence and Western blot. Results: After curcumin treatment, the MWT showed a significant increase when compared to the BPA group on both hind paws. A remarkable decrease of paw-withdrawal response frequency was observed compared with the BPA group. In addition, curcumin treatment significantly decreased the levels of TNF-α and IL-6 in rat spinal cords that were exceedingly upregulated in the BPA group. The protein levels of c-Fos and NGF were decreased by treatment with curcumin compared with the corresponding protein levels in the BPA group. Besides, curcumin reduced the number of GFAP positive cells and GFAP expression. Conclusions: Our findings suggest that curcumin significantly extenuates the BPA-induced pain and inflammation by reducing the expression level of proinflammatory cytokines and pain-associated proteins and inhibiting the activity of astrocytes.

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Comparison of the effects of curcumin, tramadol and surgical treatments on neuropathic pain induced by chronic constriction injury in rat

Abstract: CCI-CCR-tramadol treatment is highly effective in the symptomatic treatment of neuropathic pain. CCR-curcumin is associated with less degeneration and high levels of regeneration in the nerve tissue.

Cited by 14 publications

References 14 publications

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Key Developments in the Potential of Curcumin for the Treatment of Peripheral Neuropathies

Administration of Curcumin Alleviates Neuropathic Pain in a Rat Model of Brachial Plexus Avulsion

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