Comparison of the effects of deferasirox, deferiprone, and deferoxamine on the growth and virulence of <i>Vibrio vulnificus</i>

Neupane, Ganesh Prasad; Kim, Dong-Min

doi:10.1111/j.1537-2995.2009.02186.x

Cited by 35 publications

(20 citation statements)

References 22 publications

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“…Hydroxypyridinones have the potential to yield new specialized iron chelators through chemical functionalization and modification, and present with low toxicities and good biocompatibility (Santos et al, 2012;Zhou et al, 2012). Unlike deferoxamine, which is a siderophore for some bacteria (Neupane and Kim, 2009), DIBI and deferiprone are synthetic hydroxypyridinone-class chelators. DIBI is predicted to bind iron in a molar ratio of greater than one and more avidly than deferiprone or MAHMP (coordination number greater than 2), given its multiple integral MAHMP residues, each of which can presumably coordinate iron intra-cooperatively, i.e., proximal MAHMP residues in DIBI coordinating iron.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells

Coombs

Grant

Greenshields

et al. 2015

Experimental and Molecular Pathology

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells

Coombs

Grant

Greenshields

et al. 2015

Experimental and Molecular Pathology

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“…A more dramatic inhibition of bacterial growth was probably not achieved because some types of bacteria can use FO as an iron source. 28 Nonetheless, a greater inhibition of bacterial growth was achieved using higher concentrations of the bidentate ferrous iron chelator, 2,2Ј-dipyridyl 29 ( Figure 6D). This inhibitory effect was similarly abrogated when the 2,2Ј-dipyridyl was preincubated with a one-third molar ratio of ferric citrate.…”

mentioning

confidence: 99%

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

Hod

Zhang²,

Sokol

et al. 2010

Blood

411

498

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Although red blood cell (RBC) transfusions can be lifesaving, they are not without risk. In critically ill patients, RBC transfusions are associated with increased morbidity and mortality, which may increase with prolonged RBC storage before transfusion. The mechanisms responsible remain unknown. We hypothesized that acute clearance of a subset of damaged, stored RBCs delivers large amounts of iron to the monocyte/macrophage system, inducing inflammation. To test this in a well-controlled setting, we used a murine RBC storage and transfusion model to show that the transfusion of stored RBCs, or washed stored RBCs, increases plasma nontransferrin bound iron (NTBI), produces acute tissue iron deposition, and initiates inflammation. In contrast, the transfusion of fresh RBCs, or the infusion of stored RBC-derived supernatant, ghosts, or stroma-free lysate, does not produce these effects. Furthermore, the insult induced by transfusion of stored RBC synergizes with subclinical endotoxinemia producing clinically overt signs and symptoms. The increased plasma NTBI also enhances bacterial growth in vitro. Taken together, these results suggest that, in a mouse model, the cellular component of leukoreduced, stored RBC units contributes to the harmful effects of RBC transfusion that occur after prolonged storage. Nonetheless, these findings must be confirmed by prospective human studies.

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“…13 Previous study showed that long term use of chelating agent may induce hepatotoxicity. 12 In this study, the parameters related to the liver functions, such as SGOT and SGPT, were not significantly different between the two groups (Table 4). It might be caused by the relatively similar time range in the use of chelating agents among the participants.…”

mentioning

confidence: 53%

Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children

Rindarwati¹,

Diantini²,

Lestari³

2016

PCPR

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Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients. The most commonly used chelating agents are deferasirox and deferiprone. However, information regarding their effectiveness and side effects in Indonesian children population with TM were limited. This study was conducted to assess the effectiveness and side effects of deferasirox and deferiprone in pediatric patients with TM. This was an observational study with prospective analysis which was conducted during April-August 2015. We included pediatric patients with TM who visited a hospital in Bandung, Indonesia, using consecutive sampling method. Thirty two subjects were divided into two groups, i.e., deferasirox and deferiprone group. Review of medical records and interview were performed for each participants. Effectiveness was defined as reduction in ferritin level. Side effects were assessed using Naranjo scale. Data were analyzed using Mann-Whitney test, Wiloxon test and Chi square test. P value < 0.05 defined statistical significance. We found that deferasirox was more effective than deferiprone for the treatment of TM in pediatric patiens, with less side effects. The use of deferasirox as iron chelating agent is recommended for patients with TM.

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Comparison of the effects of deferasirox, deferiprone, and deferoxamine on the growth and virulence of Vibrio vulnificus

Abstract: When patients with iron overload need iron chelation therapy, especially in a population at high risk for V. vulnificus in its endemic season, DFS or DFP may be safely used rather than DFO.

Cited by 35 publications

References 22 publications

Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells

Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children

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