Comparison of the effects of two intrathecal anaesthetic techniques for transurethral prostatectomy on haemodynamic and pulmonary function

Abstract

The addition of fentanyl 25 microg to bupivacaine 10 mg and limiting the spread of the block does not improve either haemodynamic or pulmonary function compared with bupivacaine 15 mg in patients undergoing transurethral prostatectomy.

Combination of a reduced dose of an intrathecal local anesthetic with a small dose of an opioid: A meta-analysis of randomized trials

“…Trials were published between 1992 and 2012 and included data on 1393 patients, 733 of whom received intrathecal opioids (Table 1) [1,[3][4][5][6][7][8][11][12][13][14]22,[24][25][26][27]29,30,32,34,35,38,39,[42][43][44][45][46]. The median group size was 20 patients (range, 10-60 patients).…”

“…In the other 17 reports, there was a large variety of working hypotheses: different analgesic efficacy and different risks of adverse effects with experimental interventions [1,3,8,11,14,26,32,44]; improved analgesia and fewer adverse effects [13,25]; improved analgesia and equal risk of adverse effects [30]; equal analgesia and equal risk of adverse effects [22]; fewer adverse effects with no statement about analgesic efficacy [6,29,45]; and improved analgesia and potentially increased risk of adverse effects [27,35]. Selection of the LA dose in controls was based on literature findings in 6 reports [7,12,26,38,43,45], on previous personal findings in 2 [24,29], but unclear in the remaining 18 (64%).…”

“…Appendix A, Supplemental Data 10) [3,5,11,12,14,22,[24][25][26][27]30,32,34,38,44]. There was no significant difference between groups in the risk of bradycardia (defined as a heart rate <45-50 min À1 or the need for atropine) ( Fig.…”

Pulmonary effects of bupivacaine, ropivacaine, and levobupivacaine in parturients undergoing spinal anaesthesia for elective caesarean delivery: A randomised controlled study

“…However, previous investigation in patients undergoing transurethral resection of the prostate demonstrated that lung function was not altered when fentanyl was added to bupivacaine for spinal anesthesia. 24 Although fentanyl might reduce respiratory drive, it would be unlikely to affect capacity.…”