Pulmonary effects of bupivacaine, ropivacaine, and levobupivacaine in parturients undergoing spinal anaesthesia for elective caesarean delivery: A randomised controlled study

Lirk, Philipp; Kleber, N.; Mitterschiffthaler, G.; Keller, Christian; Benzer, A.; Pütz, G.

doi:10.1016/j.ijoa.2009.03.015

Cited by 8 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study, the neonatal effects of levobupivacaine and bupivacaine in combination with fentanyl were similar. In a study by Lirk et al .,[ 34 ] intrathecal bupivacaine, ropivacaine, and levobupivacaine used for CS produced similar effects on neonates (as evaluated by APGAR scores and the pH of arteries in the umbilical cord). In another study,[ 29 ] after combination of sufentanil with bupivacaine, ropivacaine, and levobupivacaine, APGAR scores and the pH of arteries in the umbilical cord in neonates did not differ; our results are consistent with that study.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have demonstrated the effect of a combination of local anesthetic and opioid for regional anesthesia in CS both extradurally[ 1 20 29 ] and intrathecally;[ 19 30 31 32 33 34 35 ] different results with regard to the characteristics of sensorial blockade between levobupivacaine and bupivacaine have been observed. However, most of these studies have concluded that there was less motor blockade with levobupivacaine than with bupivacaine.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A randomized clinical study comparing spinal anesthesia with isobaric levobupivacaine with fentanyl and hyperbaric bupivacaine with fentanyl in elective cesarean sections

2015

View full text Add to dashboard Cite

Background:To date, racemic bupivacaine is the most popular local anesthetic for spinal anesthesia in parturients undergoing elective cesarean delivery. With the introduction of levobupivacaine as pure S (–) enantiomer of bupivacaine which offers advantages of lower cardiotoxicity and neurotoxicity and shorter motor block duration, its use has widely increased in India. However, very few studies have been conducted about its efficacy in obstetric anesthesia. Thus, this study was undertaken to compare the sensorial, motor block levels, and side-effects of equal doses of hyperbaric bupivacaine and levobupivacaine with intrathecal fentanyl addition in elective cesarean cases.Materials and Methods:After approval of College Ethical Committee, 30 parturient with American Society of Anesthesiologists I-II undergoing elective cesarean section were enrolled for study with their informed consent. They were randomly divided equally to either Group BF receiving 10 mg (2 ml) hyperbaric bupivacaine and 25 mcg (0.5 ml) fentanyl, or Group LF receiving 10 mg (2 ml) isobaric levobupivacaine and 25 mcg (0.5 ml) fentanyl. Sensory and motor block characteristics of the groups were assessed with pinprick, cold swab, and Bromage scale; observed hemodynamic changes and side-effects were recorded. Effects on the neonate were observed by APGAR score at 1 and 5 min and umbilical cord blood gas analysis.Results:Hemodynamic parameters like mean arterial pressure of Group BF were found to be lower. Group BF exhibited maximum motor block level whereas in Group LF, max sensorial block level and postoperative visual analog scale scores were higher. Umbilical blood gas pCO2 was slightly higher, and pO2 was marginally lower in Group BF. Onset of motor block time, time to max motor block, time to T10 sensorial block, reversal of two dermatome, the first analgesic need were similar in both groups.Conclusion:Intrathecal isobaric levobupivacaine-fentanyl combination is a good alternative to hyperbaric bupivacaine-fentanyl combination in cesarean surgery as it is less effective in motor block, it maintains hemodynamic stability at higher sensorial block levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A randomized clinical study comparing spinal anesthesia with isobaric levobupivacaine with fentanyl and hyperbaric bupivacaine with fentanyl in elective cesarean sections

2015

View full text Add to dashboard Cite

show abstract

“…Un bloc moteur trop étendu peut être à l'origine des difficultés respiratoires au cours de la rachianesthésie. En cas d'extension thoracique haute, la réduction de la participation intercostale à l'effort ventilatoire réduit le volume de réserve expiratoire et la capacité vitale [ 17 ]. La position de Trendelenburg pourrait majorer cette extension en fonction de la baricité du produit anesthésique [ 18 ].…”

Section: Discussionunclassified

Etats hémodynamiques et respiratoires des opérées de fistules obstétricales sous rachianesthésie au CHRR Manakara, Madagascar

Martinetti¹,

Franklin²,

Lalao³

et al. 2016

Pan Afr Med J

View full text Add to dashboard Cite

L'objectif était d'évaluer les états hémodynamiques et respiratoires des opérées de fistules obstétricales et rapporter nos expériences sur la prise en charge de ces malades. Il s'agit d'une étude transversale descriptive effectuée au Bloc opératoire et Réanimation du CHRR Manakara allant du 20 au 30 aout 2013. Etaient incluses les patientes opérées de fistules obstétricales sous rachianesthésie. Nous avons exclu les patientes classées ASA >2 et celles ayant des tares cardio-vasculaires ou respiratoires. Après consultations préanesthésiques, et bilans préopératoires, nous avons administré chez les patientes 12,5mg de bupivacaïne adrénalinée 0,5% isobare en intrathécal. Elles étaient mises en position de Trendelenburg 5 minutes après l'injection du produit anesthésique et durant toute l'intervention. Le niveau sensitif, la pression artérielle, la fréquence cardiaque, la fréquence respiratoire et la saturation pulsée en oxygène (SpO2) étaient enregistrés pendant l'intervention. Nous avons retenues 57 malades. Le bloc sensitivomoteur était excellent pour toutes les malades. Un niveau métamérique supérieur à T6 était atteint chez 56,36% des malades. A part quelques épisodes d'hypertension artérielle et tachycardie, nous n'avons trouvé aucune difficulté respiratoire ni cardiovasculaire en rapport avec la position. Seuls, le niveau sensitif et la fréquence respiratoire présentaient une corrélation (p=0,01). Cette étude suggère que la position de Trendelenburg est réalisable au cours de la rachianesthésie en utilisant un produit anesthésique approprié, en faisant attention, notamment aux changements de position et en tenant compte de l'examen préanesthésique.

show abstract

Pulmonary Fibrosis

Nguyen¹,

Coleman²,

Zakowski³

2018

Consults in Obstetric Anesthesiology

View full text Add to dashboard Cite

Pulmonary effects of bupivacaine, ropivacaine, and levobupivacaine in parturients undergoing spinal anaesthesia for elective caesarean delivery: A randomised controlled study

Cited by 8 publications

References 26 publications

A randomized clinical study comparing spinal anesthesia with isobaric levobupivacaine with fentanyl and hyperbaric bupivacaine with fentanyl in elective cesarean sections

A randomized clinical study comparing spinal anesthesia with isobaric levobupivacaine with fentanyl and hyperbaric bupivacaine with fentanyl in elective cesarean sections

Etats hémodynamiques et respiratoires des opérées de fistules obstétricales sous rachianesthésie au CHRR Manakara, Madagascar

Pulmonary Fibrosis

Contact Info

Product

Resources

About