Comparison of the Effects of Added .ALPHA.- and .BETA.-Tricalcium Phosphate on the Basic Properties of Apatite Cement

Nakagawa, Akitoshi; Matsuya, Shigeki; Takeuchi, Akari; Ishikawa, Kunio

doi:10.4012/dmj.26.342

Cited by 16 publications

(16 citation statements)

References 12 publications

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“…Besides the aforementioned, it is important to mention on concretes, after hardening consisting of calcium orthophosphates only [237,238,377,[451][452][453][454]. The first biphasic composition consisting of a hardened DCPD matrix filled with β-TCP granules was introduced in 1992 [452].…”

Section: Reinforced Self-setting Formulations and Concretesmentioning

confidence: 99%

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Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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Section: Reinforced Self-setting Formulations and Concretesmentioning

confidence: 99%

“…Effects of added α-TCP and β-TCP were investigated to shed light on the setting reaction of apatite cement consisting of TTCP and DCPA [454]. Added β-TCP showed no reactivity, and thus resulted in extended setting time and decreased mechanical strength.…”

Section: Reinforced Self-setting Formulations and Concretesmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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“…Otherwise, additive plays like pore and result in the decrease in mechanical strength. 19), 20) Fortunately, addition of the proper amount of alite resulted in the increase of mechanical strength of set AC. When the DTS values of the AC containing 2.5 mass alite and no alite were compared, the former was approximately 1.7 times larger than the latter.…”

Section: Discussionmentioning

confidence: 99%

Effects of tricalcium silicate addition on basic properties of .ALPHA.-tricalcium phosphate cement

Cardenas

Takeuchi

Matsuya

et al. 2008

J. Ceram. Soc. Japan

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Addition of tricalcium silicate (Ca 3 SiO 5 ; alite) to apatite cement (AC) may be effective to increase the osteoconductivity of AC. However, only limited studies have been made so far for the effect of alite addition on the basic setting properties of a-tricalcium phosphate [a-Ca 3 (PO 4 ) 2 ; a-TCP] based cement. In the present study, effects of added alite on the basic properties of a-TCP based AC was studied. a-TCP powder containing 0.0, 2.5, 5.0, 10.0, and 20.0 mass alite were mixed with 0.25 mol/ L sodium dihydrogen phosphate solution (NaH 2 PO 4 ) and the obtained cement pastes were stored in 100 relative humidity at 37°C. Initial setting time was delayed with increase in alite content. The 2.5-5.0 mass of alite added cements were completely transformed into apatite within 24 h and the final mechanical strength of the set cement increased reaching approximately 15 MPa in terms of diametral tensile strength when compared with alite-free cement which showed approximately 9 MPa. However, 10.0-20.0 mass of alite addition suppressed the apatite formation and decreased the mechanical strength of the set cement. We concluded therefore, that addition of appropriate amount of alite to a-TCP is desirable with respect to the setting properties of AC.

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“…This implies longer permanence of β-TCP and of HA in the body 9,10 . TCPs are porous, resorbable, biocompatible materials, provoke little if any inflammatory response, permit the ingrowth of cells and vessels and have a direct connection with bony structure 26,27 . According to Den Boer et al 11 , several types of hydroxyapatite compounds have been tested for osteoconduction, and have yielded similar results to those obtained from autogenous grafts.…”

Section: Introductionmentioning

confidence: 99%

“…They are characterized by relatively low tensile strength and low fatigue resistance 9 . The higher the number of small pores for a given total porosity, the more resistant the material will be 12,26 . Shima et al 13 reduced the size of cement granules in order to decrease pore size and thus increase mechanical strength of cement.…”

Section: Introductionmentioning

confidence: 99%

Comparative histomorphometric analysis between α-Tcp cement and β-Tcp/Ha granules in the bone repair of rat calvaria

et al. 2011

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This study compared the effect of two bioceramics on the process of bone repair: α-tricalcium phosphate (α-TCP) cement and β-tricalcium phosphate hydroxyapatite particles (β-TCP/HA). Calvarial defects were created in 50 rats, divided into two groups (α and β/HA). Software was used at 7, 21, 60, 90 and 120 days to assess bone formation. Mean new bone formation rates were as follows: α group, 1.6% at 7 days, 5.24% at 21 days, 24% at 60 days, 30.21% at 90 days and 50.59% at 120 days; β/HA group, 1.94% at 7 days, 2.53% at 21 days, 12.47% at 60 days, 26.84% at 90 days and 38.82% at 120 days; control group, 0.15% at 7 days, 10.12% at 21 days, 15.10% at 60 days, 18.94% at 90 days, 48.50% at 120 days. Both materials are osteoconductive and biocompatible. Perhaps the larger rate of new bone formation observed in the α-TCP group, it also occurs in the β-TCP/HA group within a longer time period.

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Comparison of the Effects of Added .ALPHA.- and .BETA.-Tricalcium Phosphate on the Basic Properties of Apatite Cement

Cited by 16 publications

References 12 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Effects of tricalcium silicate addition on basic properties of .ALPHA.-tricalcium phosphate cement

Comparative histomorphometric analysis between α-Tcp cement and β-Tcp/Ha granules in the bone repair of rat calvaria

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