Comparison of the effects of ethane-1-hydroxy-1,1-diphosphonate and dichloromethylene diphosphonate upon periodontal bone resorption in rice rats (Oryzomys palustris)

Role of periodontal disease in bisphosphonate‐related osteonecrosis of the jaws in ovariectomized rats

“…BPs have shown favorable effects in controlling periodontal diseases by reducing alveolar bone loss and improving periodontal index (Rocha et al 2004;Lane et al 2005). Animal studies also demonstrated similar findings (Leonard et al 1979;Shoji et al 1995;Docquier et al 2002;Mitsuta et al 2002).…”

Zoledronate Effects on Systemic and Jaw Osteopenias in Ovariectomized Periostin-Deficient Mice

“…Clinical studies demonstrated a reduction of radiological and/or clinical signs of PD, including alveolar bone loss, gingival index and bleeding [8], [9], [10], [11], [12]. These beneficial effect of bisphosphonates on mandibular bone loss have also been demonstrated in animal models of PD such as the rice rat [13], [14], and/or as induced by elastic rings [15], [16], tooth ligature [7], [17], and bacterial inoculations [18], [19].…”

Effects of Topical Administration of Clodronate on Alveolar Bone Resorption in Rats With Experimental Periodontitis

“…7,8 Previous studies have shown that systemic administration of BPs is effective for preventing alveolar bone loss in experimental periodontitis. [9][10][11][12][13] Since most periodontitis is usually a local disease caused by local factors associated with plaque bacteria and mechanical stress, 7,8,14 the localized use of BPs at specific sites without systemic effects on general bone metabo-lism would be desirable when the clinical application of BPs to treat alveolar bone loss is considered. Therefore, the present study was designed to examine whether topical administration of a bisphosphonate clodronate could prevent alveolar bone resorption in rats with experimental periodontitis.…”