Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats

Tamaddonfard, Esmaeal; Farshid, Amir Abbas; Eghdami, Karim; Samadi, Farzad; Erfanparast, Amir

doi:10.1016/s1734-1140(13)71485-3

Cited by 66 publications

(53 citation statements)

References 43 publications

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“…Bitter substances derived from safranal and crocin carotenoid pigment (an important component of saffron stigma) are said to have pharmacological effects (7,8). Some studies investigated the many medicinal applications of saffron including induction of abortion (9), increasing uterine contractions (10,11), analgesic and antiinflammatory properties (12)(13)(14), anti-anxiety (15)(16)(17), sedation (18), and labor pain (19). Authors' recent trial also showed that oral capsules of saffron increased the Bishop score in term pregnant females with no labor pain (20).…”

Section: Introductionmentioning

confidence: 99%

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Mohammadierad¹,

Mohammad‐Alizadeh‐Charandabi²,

Mirghafourvand³

et al. 2018

Iran Red Crescent Med J

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Background: Reduction of pain and anxiety during labor is necessary to prevent some of the maternal and fetal complications, as well as request for cesarean section. There is limited evidence assessing the effects of saffron and dates on intensity of pain and anxiety. Objectives: The current study aimed at examining the effect of saffron with or without dates on the intensity of pain and anxiety during transitional and active phases of labor in primiparous females. Methods: In the current superiority trial, 96 primiparous females admitted to a hospital covered by the iranian social security organization in Tabriz, Iran, at the onset of active phase of labor were recruited using convenience sampling method from 10 January to 21 October 2016. They were randomly divided into three equal groups using block randomization; receiving 80 mL oral syrup of saffron (250 mg) plus date juice (65 g), saffron (250 mg) plus white sugar (165 mg sodium saccharin and 420 mg sodium carboxymethyl cellulose), or placebo every two hours for maximum three doses (240 mL). Intensity of pain and anxiety were assessed using 0-10 visual analogue scale every one hour. Results: Compared with the placebo, mean scores of both pain and anxiety were lower in the intervention groups. The differences were statistically significant at the saffron plus date juice group (adjusted mean difference: -0.8 (95% confidence interval (CI): -1.5 -0.0), P = 0.022 and -1.3 (95% CI: -2.4 to -0.2), P = 0.012, respectively), but were not significant at the saffron plus white sugar group (-0.5 (95% CI: -1.2 -0.2), P = 0.322 and -1.1 (95% CI: -2.2 -0.0), P = 0.058, respectively). The differences between the two intervention groups were not statistically significant (-0.3 (95% CI: -1.0 -0.4), P = 0.557 and -0.2 (95% CI: -1.3 -0.8), P = 0.927, respectively). One subject from saffron plus date juice, three from saffron plus white sugar, and four from the placebo groups had emergency cesarean section. Conclusions: The current study results showed that the oral syrup of saffron plus date juice could be used to reduce the intensity of pain and anxiety during labor in primiparous females. However, the results were inconclusive for the effects of saffron plus white sugar.

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Section: Introductionmentioning

confidence: 99%

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Mohammadierad¹,

Mohammad‐Alizadeh‐Charandabi²,

Mirghafourvand³

et al. 2018

Iran Red Crescent Med J

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“…The research showed that crocin and safranal showed antiinflammatory and antinociceptive effects in carrageenan model of inflammation and inflammatory pain. Crocin and safranal anti-inflammatory and antinociceptive effects were the same as those of diclofenac, as a reference drug (Tamaddonfard et al, 2013). There are many studies that show the neuroprotective activities of crocin and crocetin in experimental models of brain disorders, for instantce cerebral ischemia, memory impairment and Parkinson's disease (Zhang et al, 1994;Zheng et al, 2007;Ahmad et al, 2005).…”

Section: Antiinflammatuar Effect Of Saffronmentioning

confidence: 85%

“…Antiinflamatuar effect of saffranal is investigated by Tamaddonfard et al (2013). The research showed that crocin and safranal showed antiinflammatory and antinociceptive effects in carrageenan model of inflammation and inflammatory pain.…”

Section: Antiinflammatuar Effect Of Saffronmentioning

confidence: 99%

Therapeutic Potential of Saffron Crocus (Crocus sativus L.)

Selamoğlu

Özgen

2016

Turkish JAF Sci.Tech.

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Herbal plants are using for folk medicine since immemorial times. Hippocrates who is the father of medicine, refer to 400 medicinal plants and advised ‘‘let food be your medicine and let medicine be your food’’. Most of plants are using today for medicine. It is still acceptable today that prevention is more important than treatment. Saffron was utilized in folk remedy against scarlet fever, smallpox, colds, asthma, eye and heart diseases, tumours, and cancer.

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“…31 In a parallel study results demonstrated that ingredients of saffron such as crocin and safranal suppressed inflammatory pain response as well and decreased the number of neutrophils. 32 …”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Saffron (Crocus sativus) and its Active Ingredients: Role in the Prevention and Treatment of Disease

Rahmani¹,

Khan²,

Aldebasi³

2017

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Introduction:Crocus sativus is a member of iridaceae family and its use in health management is in practice since ancient time. Additionally, research based on clinical trials and animal models have advocates its role in disease cure without any severe adverse complications. The aim of this study is to summarize the study of saffron and its ingredients based on in vivo and in vitro and role in disease cure and prevention. Materials: This study was designed through the search engines such as Pub Med, Scopus and Google Scholar. The keywords used for the search were mainly focused on Saffron with health benefit and its therapeutics role in different diseases. Result: Saffron stigma is mixture of various components and recent studies have proven that saffron and its active ingredients play a key role in disease management. Moreover, clinical trials based study on the use of saffron and its individual components have confirmed the health promising effects. Conclusion: Although Saffron has potential role in the disease cure and prevention via modulation of anti-oxidant, anti-inflammatory, anti-tumour, anti-microbial and anti-diabetic activity. Furthermore, advanced research is needed to elaborate the role of saffron in health management and its mechanism of action in the modulation of biological activities.

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Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats

Abstract: The present study showed anti-inflammatory and antinociceptive activities for crocin, safranal and diclofenac in carrageenan model of local inflammation and inflammatory pain.

Cited by 66 publications

References 43 publications

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Therapeutic Potential of Saffron Crocus (Crocus sativus L.)

Saffron (Crocus sativus) and its Active Ingredients: Role in the Prevention and Treatment of Disease

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