Comparison of the effects of tens and sodium salicylate iontophoresis in the management of osteoarthritits of the knee

Aiyejusunle, C B; Kola-Korolo, T A; Ajiboye, Olufunke Adewumi

doi:10.4314/nqjhm.v17i1.12539

Cited by 13 publications

(14 citation statements)

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“…These results are in agreement with previous reports in which other authors showed that iontophoresis aids in better treatment of joint disorders (26,27). Aiyejusunle et al have reported that cathodal iontophoresis (0.1-0.3 mA/cm 2 ) of sodium salicylate resulted in reduced pain and functional disability (26). Bender et al have shown that the concentration of etofenamate in the synovial fluid following iontophoresis was twice that of etofenamate levels in serum, and, hence, topical iontophoresis of etofenamate was suitable for alleviation of arthritis in superficially located joints (27).…”

Section: Iontophoretic Drug Deliverysupporting

confidence: 96%

“…Iontophoresis-mediated delivery of drugs resulted in 3-fold (P<0.01) higher AUC 0-t in synovial fluid compared to passive drug delivery (Tables I, II). These results are in agreement with previous reports in which other authors showed that iontophoresis aids in better treatment of joint disorders (26,27). Aiyejusunle et al have reported that cathodal iontophoresis (0.1-0.3 mA/cm 2 ) of sodium salicylate resulted in reduced pain and functional disability (26).…”

Section: Iontophoretic Drug Deliverysupporting

confidence: 92%

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“ChilDrive”: A Technique of Combining Regional Cutaneous Hypothermia with Iontophoresis for the Delivery of Drugs to Synovial Fluid

Sammeta

Murthy

2009

Pharm Res

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Section: Iontophoretic Drug Deliverysupporting

confidence: 96%

Section: Iontophoretic Drug Deliverysupporting

confidence: 92%

“ChilDrive”: A Technique of Combining Regional Cutaneous Hypothermia with Iontophoresis for the Delivery of Drugs to Synovial Fluid

Sammeta

Murthy

2009

Pharm Res

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“…The treatment responses emanated from patients with the use of 5% Ibuprofen iontophoresis followed similar trend as found in the earlier studies [8] [17] [18]. Xiaoying et al, reported that iontophoresis facilitated local and systemic delivery of ionisable drugs such as ibuprofen and sodium diclofenac, compared with passive diffusion.…”

Section: Discussionsupporting

confidence: 72%

“…It is a non-invasive procedure by which high concentration of ionisable substances, mostly medications or bio-active agents, is propelled transdermally by repulsive electromotive force generated from two electrodes fastened over the overlying skin of the body segment [13]. Existing data have shown therapeutic gains of this procedure when combined with therapeutic exercises [8] [9]. In spite of the documented therapeutic effects of TENS and iontophoresis however, their comparative efficacies in combination with exercise, have been minimally evaluated.…”

Section: Introductionmentioning

confidence: 99%

5% Ibuprofen Iontophoresis Compared with Transcutaneous Electrical Nerve Stimulation in the Management of Knee Osteoarthritis: A Feasibility Study

Bello¹,

Kuwornu²

2014

OJTR

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Objective: The study compared the inclusions of 5% ibuprofen iontophoresis and Transcutaneous Electrical Nerve stimulation (TENS) in the management of osteoarthritis (OA) of the knee joint. Subjects and Methods: Patients diagnosed with knee OA and referred for physiotherapy at a tertiary health facility in Accra, Ghana participated in the study. They were alternately assigned into either TENS or iontophoresis groups. Patients in TENS Group received conventional TENS mode while those in iontophoresis group were treated with 5% ibuprofen iontophoresis using galvanic electrical current. Both protocols were performed twice weekly for six weeks in addition to their prescribed therapeutic exercises. 15-minute walking time, Numerical Rating Scale and Goniometer were used as the main outcome measures to determine subjects' walking speed, pain and active range of motion (AROM) respectively. Treatment evaluation was performed at baseline, week 3 and week 6 by an independent assessor. Comparisons of variables within and between groups were tested using Friedman's mean rank and Mann-Whitney U tests respectively at p < 0.05. Results: Participants in both groups were not significantly different in age (p = 0.460), height (p = 0.548) and weight (p = 0.810). Significant improvements were recorded for walking speed (p = 0.001), pain (p = 0.001) and AROM (p = 0.001) of the * Corresponding author.A. I. Bello, S. Kuwornu 167 subjects within groups. However, between group comparison of the treatment variables showed no significant differences (p > 0.05) for all the outcome measures. Conclusion: 5% ibuprofen iontophoresis and TENS add equal therapeutic value in the management of knee OA. Consideration of both modalities as adjuncts to therapeutic exercises is therefore worthwhile for managing the condition.

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“…Indeed, there are very few publications that deal with this subject. With the keyword « joint pain, analgesic, Africa », only 17 publications were found from the PubMed database in August 2015 of which two directly related to the assessment of the effects of analgesic in arthritis [4, 5] and about half of them are related to viral infections. This result prompted us to conduct a study in which the main objective was to describe the characteristics of patients with joint pains treated with analgesics in an African context where prescription is based on the purchasing power of patients.…”

Section: Introductionmentioning

confidence: 99%

Joint pain epidemiology and analgesic usage in Madagascar

Samison¹,

Randriatsarafara²,

Ralandison³

2017

Pan Afr Med J

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IntroductionTo describe the epidemiology of joint pains and document analgesics usage in an African context.MethodsPatients suffering from joint pain were recruited from nine sites located in Antananarivo, Madagascar, including 6 hospital services and 3 clinics. Doctors collected information on the etiology and characteristics of the patients’ pain. Analgesics prescribed by these doctors were also documented.ResultsIn total, 400 patients were enrolled in the study (52.5% women, mean age of 42.34 years ± 17.7 [4-86]). Pain of mechanical type was found in 260 participants, 65%; 95% CI [60.1% to 69.6%] and inflammatory type pains in 128 cases 32%; 95% CI [27.5% to 36.9%]. Mixed pains were found in 12 patients (3%). The median duration of pain prior to the consultation was 6.5 days. The average pain intensity was 57.9 ± 19.9 mm of a total of 100 mm maximum on a visual analogue scale, VAS. The etiologies of mechanical type pains were dominated by fracture, common low back pain and tendonitis. Arthrosis was the dominant cause of inflammatory type pain, followed by rheumatoid arthritis and gout. NSAIDs (74.5%) were the most frequently prescribed analgesics followed by paracetamol (49.5%), weak opioids (23%) and corticosteroids (12.25%). Two-thirds of medical prescriptions (65.3%) were of combined analgesics.ConclusionThese findings demonstrated that mechanical type pains were the main reason for consultations for joint pain in these situations in Antananarivo, Madagascar. The most frequently prescribed pain-relieving medications were NSAIDs, paracetamol, weak opioids and corticosteroids. This descriptive study may be a useful starting point for further epidemiological studies of pain in the African context.

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Comparison of the effects of tens and sodium salicylate iontophoresis in the management of osteoarthritits of the knee

Cited by 13 publications

References 0 publications

“ChilDrive”: A Technique of Combining Regional Cutaneous Hypothermia with Iontophoresis for the Delivery of Drugs to Synovial Fluid

“ChilDrive”: A Technique of Combining Regional Cutaneous Hypothermia with Iontophoresis for the Delivery of Drugs to Synovial Fluid

5% Ibuprofen Iontophoresis Compared with Transcutaneous Electrical Nerve Stimulation in the Management of Knee Osteoarthritis: A Feasibility Study

Joint pain epidemiology and analgesic usage in Madagascar

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