According to the literature, microorganisms of the genus Kocuria are becoming widespread, but not as avirulent representatives of the normal microbiota of the human body, but as pathogens.
Recently, after the identification of the causative agents of infectious and inflammatory processes, various types of Kocuria have been included in the list of etiological agents isolated from patients with cholecystitis, endocarditis, peritonitis, and meningitis as well as from carious tooth cavities and post-extraction tooth sockets. Bacteria of the genus Kocuria possess pathogenicity that enables them to play an important role in the occurrence of infectious and inflammatory processes in various organs and systems of the human body. Given that antibiotics are the most commonly used drugs of choice in medical and dental practice for the treatment of infections and inflammations, antibiotic resistance is considered as a global health and development threat.
In order to overcome the challenge of antibiotic resistance, antiseptics, a group of medicines with a pronounced antimicrobial effect, are being increasingly used for the treatment of infectious and inflammatory processes. The purpose of this study is to investigate the antibacterial and antiadhesive activity of dekasan, and drugs of comparison, chlorhexidine and iodoform, against clinical isolates of Kocuria spp. isolated from the oral cavity of patients with infectious inflammatory post-extraction complications. Materials and methods: five clinical isolates of Kocuria spp. were studied as microorganisms isolated from patients, who received the treatment for infectious and inflammatory post-extraction complications at the medical and surgical departments of Poltava Regional Center of Stomatology – Dental Polyclinic. We determined the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBcC) of antiseptics against clinical isolates of Kocuria spp. taking into account ISO recommendations. The adhesive properties of clinical isolates of Kocuria spp. were assessed by exposing them to subbacteriostatic concentrations of antiseptics, namely dekasan, chlorhexidine, and iodoform. The evaluation was conducted using erythrocytes of blood group 1(0) Rh+ and considering the index of microorganism adhesion (IAM) following the method developed by V. I. Brillis. The results obtained have demonstrated variations in the antimicrobial and anti-adhesive activities among the tested antiseptics, dekasan, chlorhexidine, and iodoform.
