Comparison of the Effect of Oestrogen Plus Foeniculum vulgare Seed and Oestrogen alone on Increase in Endometrial Thickness in Infertile Women

Yavangi, Mahnaz; Rabiee, Soghra; Nazari, Shahram; Farimani-Sanoee, Marzieh; Amiri, Iraj; Bahmanzadeh, Maryam; Heidari-Soureshjani, Saeid

doi:10.7860/jcdr/2018/30164.11020

Cited by 11 publications

(10 citation statements)

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“…Its main application is on hot flashes in postmenopausal women but it can also help anxiety in those patients with depression [81]. Vaginal fennel ethanol extract cream showed an improvement of vaginal atrophy and sexual functions in menopause women due to its estrogenic effects [83]. No critical side effects have been reported [81,83].…”

Section: Herbal Derivativesmentioning

confidence: 99%

A Nutraceutical Approach to Menopausal Complaints

et al. 2019

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The menopausal transition, or perimenopause, is characterized by menstrual irregularities, vasomotor symptoms, sleep disturbances, mood symptoms, and urogenital tract atrophy. These changes can also affect the quality of life and one’s self-esteem. Hormone replacement therapy (HRT) is considered the best option to achieve therapeutic relief of different menopausal symptoms but is usually restricted to moderate or severe symptoms. Moreover, many women refuse HRT for a variety of reasons concerning the fear of cancer and other adverse effects. According to these considerations, new topics are emerging: Dissatisfaction with drug costs and conventional healthcare, desire for personalized medicines, and the public perception that “natural is good”. In this context, nonhormonal therapies are mostly evolving, and it is not unusual that women often request a “natural” approach for their symptoms. The aim of this study is to investigate nonhormonal therapies that have been identified to reduce the menopausal symptoms.

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Section: Herbal Derivativesmentioning

confidence: 99%

A Nutraceutical Approach to Menopausal Complaints

et al. 2019

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“…The total FSFI score was significantly increased in fennel group (8.2 ± 9.4 to 33.79 ± 0.7) cmopared to control group (8.03 ± 10.36 to 18.99 ± 1.09; P < 0.001). No drop out was observed in groups, which introduce it as safe and acceptable treatment 41. As the results of two clinical trials showed, vaginal fennel ethanol extract cream could improve sexual functions in menopause women due to its estrogenic effects.…”

Section: Methodsmentioning

confidence: 81%

“…No significant differences were observed between two groups in regard of demographic characteristic ( P > 0.05). The mean days to achieve endometrial thickness of at least 8 mm were 13.1 ± 3.2 and 14.2 ± 3.5 in fennel and control groups ( P > 0.05) 41. Although, fennel tea failed to achieve the adequate endometrial thickness for fertility, but evaluating the efficacy of fennel oil or extracts on fertility is recommended.…”

Section: Methodsmentioning

confidence: 90%

Foeniculum vulgareas Valuable Plant in Management of Women's Health

Mahboubi¹

2019

J Menopausal Med

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This review paper evaluates use of Foeniculum vulgare extracts as a popular female plant in management of different ailments of women. Information in this paper was gathered from accessible sources (PubMed, Science Direct, Springer, Wiley, and Google), and traditional books (Persian or English modern traditional books), unpublished data (R&D reports, thesis and dissertation) by keywords based on the words F. vulgare or fennel and women. Efficacy of oral fennel oil in management of dysmenorrhea, premenstrual syndrome, amenorrhea, menopause, lactation, and polycystic ovary syndrome were confirmed according to results of clinical studies. Results of clinical efficacy of fennel oil on menstrual bleeding is complicated, but results of one meta-analysis study revealed that fennel oil significantly increased means of bleeding in the first menstrual periodic cycle ( P = 0.001), while fennel oil had no significant effect on bleeding in the second menstrual cycle ( P = 0.67). Topical and vaginal fennel extract (5%) exhibited good efficacy in treatment of sexual function, vaginal atrophy, and hirsutism. Fennel had no effect on bone density, or body mass index of menopause women. Results of clinical studies introduce fennel as a valuable medicinal plant in management of women's ailments, but understanding the mechanism of action could be the subject of future studies.

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“…In the present study, in line with other studies, fennel consumption decreased non-significantly the atretic follicle number in the treated groups compared to that of control animals. Several factors such as estrogen could serve as follicle survival and anti-apoptotic factors [ 35 ]. This sex hormone via estrogen receptor could lead to a reduction of Fas-ligand activity [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Hydroalcoholic extract and seed of Foeniculum vulgare improve folliculogenesis and total antioxidant capacity level in F1 female mice offspring

Pourjafari

Haghpanah

Nematollahi-Mahani

et al. 2020

BMC Complement Med Ther

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Background Foeniculum vulgare (fennel) is traditionally suggested for the fertility improvement in Iranian lore due to its antioxidant and phytoestrogen compounds. The present study aimed to investigate the effects of fennel seed and its hydroalcoholic extract on the serum total antioxidant capacity (TAC) and folliculogenesis in offspring exposed to either of the treatments in utero and 56 days after birth (PND 56). Methods Pregnant NMRI mice were randomly divided into 5 groups of 7: extract-treated groups received 500 and 1000 mg/kg/day fennel extract (FE), seed-treated groups received 500 and 1000 mg/kg/day fennel seed (FS), and the control group (CTL) received no treatment. The treatments started from pregnancy day 1 and continued until PND 56. Body and right ovary weights and ovary dimensions were recorded. Hematoxylin and eosin stained ovary sections were prepared to calculate the proportion of different follicles. The level of TAC in the serums was also measured by fluorescence recovery after photo bleaching. Results A marked rise in the body and ovary weights of treated mice was observed compared to the CTL group. The mean number of primordial, primary, pre-antral, and pre-ovulatory follicles as well as corpus luteum size in the treated offspring was significantly higher compared to those of CTL offspring. The atretic follicle number was nonsignificantly lower in either of the treatment groups compared with that in the CTL. However, treatment of animals with 500 mg/kg FE showed a more pronounced effect. Animals in FS500, FE500 and FE1000 groups had a significantly higher level of serum TAC compared to the CTL group. Conclusions Fennel extract and seed administration in pregnancy and lactation period improve offspring’s folliculogenesis. Higher level of TAC in the serum of offspring might have positively altered the folliculogenesis milieu.

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Comparison of the Effect of Oestrogen Plus Foeniculum vulgare Seed and Oestrogen alone on Increase in Endometrial Thickness in Infertile Women

Cited by 11 publications

References 0 publications

A Nutraceutical Approach to Menopausal Complaints

A Nutraceutical Approach to Menopausal Complaints

Foeniculum vulgareas Valuable Plant in Management of Women's Health

Hydroalcoholic extract and seed of Foeniculum vulgare improve folliculogenesis and total antioxidant capacity level in F1 female mice offspring

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