Hydroalcoholic extract and seed of Foeniculum vulgare improve folliculogenesis and total antioxidant capacity level in F1 female mice offspring

Pourjafari, Fahimeh; Haghpanah, Tahereh; Nematollahi-Mahani, Seyed Noureddin; Pourjafari, Fariba; Ezzatabadipour, Massood

doi:10.1186/s12906-020-03083-3

Cited by 11 publications

(8 citation statements)

References 32 publications

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“…In this sense, it was determined that the GF1 group male quails from the control and other fennel-supplemented groups had a lower rate of abnormal and dead spermatozoa, a lower rate than other fennel-supplemented groups in terms of concentration, but a significantly higher rate than all other groups in terms of motility. The use of fennel, which has an antioxidant effect, is recommended to improve fertility (25). In studies using fennel oil in different animal species, an improvement in testicular histological structure and an increase in spermatological quality have been reported (26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Japon Bıldırcınlarında Yumurtlama Döneminde Yeme Rezene (Foeniculum Vulgare Mill.) İlavesinin Yumurta Verimi, Kesim ve Karkas Özellikleri, Bağırsaklarda Parazit Oluşumu ve Spermatolojik Kalite Üzerine Etkisi

Çetin

ERDEM>

DURUSOY>

et al. 2022

Dicle Üniversitesi Veteriner Fakültesi Dergisi

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This study was carried out to determine the effects of supplementation of ground fennel to quail rations on egg production, slaughter, intestinal parasites, and semen quality. For this purpose, 48 female and 24 male quails were used in the study. The experimental groups consisted of the control group with basal feed + 0% ground fennel, and the GF1, GF2, and GF4 groups with ground fennel-supplemented basal feed by 1%, 2%, and 4% respectively, also each group was designed in pairs. The weekly live weight values were found to be numerically higher in the groups with fennel-supplemented rations than in the control group. In addition, the live weight values of female and male quails were also numerically higher in the groups with fennel-supplemented rations. Egg weight, egg production, and feed intake of female quails were high, especially in the GF2 group. Furthermore, the feed conversion ratio was superior in the GF2 group. Regarding the slaughter and carcass parts, the fennel-supplemented groups were numerically higher than the control group. It was observed that the oviduct weight increased with the growing fennel ratio. In addition, the fennel supplementation increased the semen concentration in male quails. The increasing fennel addition enhanced the abnormal and dead spermatozoa rates and decreased semen motility. As a result of the macroscopic examination of the intestinal lumen of the quails in the control and fennel-supplemented groups, no adult helminths were detected; however, Giardia spp.-like cysts were observed. As a result, the usage of ground fennel as a feed additive by 2% had a positive effect on yield characteristics of female quails, and the use by 1% had a positive effect on male quails. Consequently, the usage of ground fennel as a feed additive would be beneficial in quail farming.

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Section: Discussionmentioning

confidence: 99%

Japon Bıldırcınlarında Yumurtlama Döneminde Yeme Rezene (Foeniculum Vulgare Mill.) İlavesinin Yumurta Verimi, Kesim ve Karkas Özellikleri, Bağırsaklarda Parazit Oluşumu ve Spermatolojik Kalite Üzerine Etkisi

Çetin

ERDEM>

DURUSOY>

et al. 2022

Dicle Üniversitesi Veteriner Fakültesi Dergisi

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“…1 , pregnant mice ( n = 32) were randomly assigned to following experimental groups: control group (CTL), in which the animals consumed a standard rodent chow; FV group, which the animals received hydroalcoholic extract of fennel (500 mg/kg/day) [ 20 ]; FX group, which the animals received hydroalcoholic extract of flaxseed (500 mg/kg/day) [ 20 ]; and FX + FV group, which animals received hydroalcoholic extract of flax (500 mg/kg/day) and fennel seed (500 mg/kg/day). Based on the our previous studies [ 20 , 22 ], a dose of 500 mg/Kg was chosen for both extracts as an effective dose. In order to intake a daily dose of 500 mg/Kg of extract by animals, first, in a pilot study, the required amount of extract was measured based on the animal weight for one week.…”

Section: Methodsmentioning

confidence: 99%

In utero and postnatal exposure to Foeniculum vulgare and Linum usitatissimum seed extracts: modifications of key enzymes involved in epigenetic regulation and estrogen receptors expression in the offspring’s ovaries of NMRI mice

Pourjafari

Ezzatabadipour

Nematollahi‐Mahani

et al. 2023

BMC Complement Med Ther

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Background Early-life exposure to exogenous estrogens such as phytoestrogens (plant-derived estrogens) could affect later health through epigenetic modifications. Foeniculum vulgare (fennel) and Linum usitatissimum (flax) are two common medicinal plants with high phytoestrogen content. Considering the developmental epigenetic programming effect of phytoestrogens, the main goal of the present study was to evaluate the perinatal exposure with life-long exposure to hydroalcoholic extracts of both plants on offspring’s ovarian epigenetic changes and estrogen receptors (ESRs) expression level as signaling cascades triggers of phytoestrogens. Methods Pregnant mice were randomly divided into control (CTL) that received no treatment and extract-treated groups that received 500 mg/kg/day of fennel (FV) and flaxseed (FX) alone or in combination (FV + FX) during gestation and lactation. At weaning, female offspring exposed to extracts prenatally remained on the maternal-doses diets until puberty. Then, the ovaries were collected for morphometric studies and quantitative real-time PCR analysis. Results A reduction in mRNA transcripts of the epigenetic modifying enzymes DNMTs and HDACs as well as estrogen receptors was observed in the FV and FX groups compared to the CTL group. Interestingly, an increase in ESRα/ESRβ ratio along with HDAC2 overexpression was observed in the FV + FX group. Conclusion Our findings clearly show a positive relationship between pre and postnatal exposure to fennel and flaxseed extracts, ovarian epigenetic changes, and estrogen receptors expression, which may affect the estrogen signaling pathway. However, due to the high phytoestrogen contents of these extracts, the use of these plants in humans requires more detailed investigations.

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“…The fixed tissue samples were dehydrated in ascending concentrations of alcohol and embedded in paraffin. Slices of tissue with 5 µ m thickness were prepared and stained with hematoxylin and eosin and then evaluated under a light microscope (Olympus IX51, Japan) [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Serum Scavenging Capacity and Folliculogenesis Impact following Flaxseed Consumption in the First-Generation Mice Pups

Pourjafari

Haghpanah

Palmerini

et al. 2022

Journal of Toxicology

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Flaxseed is a source of antioxidants utilized for female infertility treatment in traditional medicine. This study investigated the effects of flax hydroalcoholic extract and flaxseeds during prenatal and postnatal (PND) periods on folliculogenesis and serum total antioxidant capacity (TAC). Pregnant NMRI mice received 500 and 1000 mg/kg of flax extract (LE) and the same doses of flaxseed (LS). Female pups received the same regimen for 56 days. The body, ovarian morphometry, follicle development, and TAC levels were evaluated. The ovarian weight significantly increased in the LE1000 group compared to the LS500 group. The LE500 group had a considerably lower number of primary and antral follicles compared to the CTL and LS1000 groups. The number of antral follicles significantly increased in the LE1000 group compared to the LS500 and LE500 groups. The number of preovulatory follicles was higher in the LE1000 group. A significant increase in the TAC levels was detected in the LS500, LS1000, and LE1000 groups. LE showed a dose-dependent protective effect on the folliculogenesis in F1, which is more evident with the dosage of 1000 mg/kg. This could be related to the strongest antioxidant property of LE1000, as shown by the highest levels of TAC.

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Hydroalcoholic extract and seed of Foeniculum vulgare improve folliculogenesis and total antioxidant capacity level in F1 female mice offspring

Cited by 11 publications

References 32 publications

Japon Bıldırcınlarında Yumurtlama Döneminde Yeme Rezene (Foeniculum Vulgare Mill.) İlavesinin Yumurta Verimi, Kesim ve Karkas Özellikleri, Bağırsaklarda Parazit Oluşumu ve Spermatolojik Kalite Üzerine Etkisi

Japon Bıldırcınlarında Yumurtlama Döneminde Yeme Rezene (Foeniculum Vulgare Mill.) İlavesinin Yumurta Verimi, Kesim ve Karkas Özellikleri, Bağırsaklarda Parazit Oluşumu ve Spermatolojik Kalite Üzerine Etkisi

In utero and postnatal exposure to Foeniculum vulgare and Linum usitatissimum seed extracts: modifications of key enzymes involved in epigenetic regulation and estrogen receptors expression in the offspring’s ovaries of NMRI mice

Serum Scavenging Capacity and Folliculogenesis Impact following Flaxseed Consumption in the First-Generation Mice Pups

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