Comparison of the effect of maternal hypothyroidism on carbohydrate metabolism in young and aged male offspring in rats

Karbalaei, Narges; Ghasemi, Asghar; Faraji, Fatemeh; Zahediasl, Saleh

doi:10.3109/00365513.2012.743164

Cited by 25 publications

(38 citation statements)

References 43 publications

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“…We used a transient model of TCH, as serum concentrations of thyroid hormones and TSH were similar to controls in adult offspring, findings similar to our previous studies [10, 46] and others [27, 47]. Using anti-thyroid drugs for creating animal model of TCH is reasonable and a relatively common practice since ∼1-5% of neonates whose hyperthyroid mothers had been treated with PTU, were born with suppressed thyroid hormones [7, 48-50].…”

Section: Discussionsupporting

confidence: 62%

“…The incidence of TCH is very low in iodine-sufficient areas such as the United States (1 in 50000) or very high in the iodine-deficient areas such as Europe (1 in 100) [6] and Africa (1 in 10) [9]. Hypothyroidism during pregnancy can cause glucose intolerance during adulthood [10, 11] that is a result of disturbed intrauterine conditions [12, 13]. …”

Section: Introductionmentioning

confidence: 99%

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Transient Congenital Hypothyroidism Alters Gene Expression of Glucose Transporters and Impairs Glucose Sensing Apparatus in Young and Aged Offspring Rats

Gholami

Jeddi

Zadeh‐Vakili

et al. 2017

Cell Physiol Biochem

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Background/Aims: Transient congenital hypothyroidism (TCH) could disturb carbohydrate metabolism in adulthood. Aging is associated with increased risk of type 2 diabetes. This study aims to address effects of TCH on mRNA expressions of glucose transporters (GLUTs) and glucokinase (GcK) in islets and insulin target tissues of aged offspring rats. Methods: The TCH group received water containing 0.025% 6-propyl-2-thiouracil during gestation. Offspring from control and TCH groups (n=6 in each group) were followed until month 19. Gene expressions of GLUTs and GcK were measured at months 3 and 19. Results: Compared to controls, aged TCH rats had higher GLUT4 expression in heart (4.88 fold) and soleus (6.91 fold), while expression was lower in epididymal fat (12%). In TCH rats, GLUT2 and GcK expressions in islets were lower in young (12% and 10%, respectively) and higher in aged (10.85 and 8.42 fold, respectively) rats. In addition, liver GLUT2 and GcK expressions were higher in young (13.11 and 21.15 fold, respectively) and lower in aged rats (44% and 5%, respectively). Conclusion: Thyroid hormone deficiency during fetal period impaired glucose sensing apparatus and changed glucose transporter expression in insulin-sensitive tissues of aged offspring rats. These changes may contribute to impaired carbohydrate metabolism.

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Transient Congenital Hypothyroidism Alters Gene Expression of Glucose Transporters and Impairs Glucose Sensing Apparatus in Young and Aged Offspring Rats

Gholami

Jeddi

Zadeh‐Vakili

et al. 2017

Cell Physiol Biochem

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“…The sex-associated differences in blood pressure, observed in humans, have also been documented in animal models (Reckelhoff 2001). Finally, outcomes of impaired intrauterine growth may vary according to age of offspring ( Roland et al 2010;Karbalaei et al 2013), results that justify both ours and those of Santos et al (2012).…”

Section: Discussionmentioning

confidence: 80%

“…The fetal thyroid gland is inactive until birth (Galton et al 1999) and maternal THs are the only source of THs during fetal life (Santos et al 2012). Adverse effects of TH deficiency during fetal development have been evaluated on various systems (Chattergoon et al 2012;Karbalaei et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic properties and arterial structure in male rat offspring with fetal hypothyroidism

Ghanbari

Bagheripuor²,

Piryaei³

et al. 2016

gpb

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Abstract. Thyroid hormones (THs) play a crucial role in the development of different systems during fetal life; fetal hypothyroidism (FH) is associated with reduced cardiac function and dimensions in neonates. The aim of this study is to determine whether TH deficiency during fetal life is associated with arterial structural and hemodynamic changes during adulthood. Hypothyroidism was induced by adding 0.025% 6-propyl-2-thiouracil in drinking water throughout pregnancy, while controls consumed only tap water. Hemodynamic parameters, cross-sectional area, intima-media thickness (IMT), and density of nuclei of smooth muscle cells and endothelial cells (ECs) in the aorta and mesenteric arteries were measured. Compared to controls, in the FH group, baseline systolic blood pressure (105.7 ± 3.1 vs. 87.9 ± 3.3 mm Hg, p < 0.01), diastolic blood pressure (64.4 ± 1.7 vs. 53.2 ± 2.1 mm Hg, p < 0.05), and mean arterial pressure (80.9 ± 2.1 vs. 67.1 ± 2.1 mm Hg, p < 0.01) were significantly lower. In addition, in the FH group, intensity and latency of response to phenylephrine were significantly lower and longer, respectively, as were the IMT and density of ECs in the aorta and superior mesenteric arteries. In conclusion, this study showed that TH deficiency during fetal life can have long-lasting functional and histological effects, which can compromise cardiovascular function during adulthood.

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“…Fetal abdominal fat was highest with low protein maternal diet; and fetal midthigh fat was highest at intermediate protein, high fat, and low carbohydrate diets (45). Maternal hypothyroidism may cause glucose intolerance and may contribute to the increased risk of type 2 diabetes in the offspring in rats (46). Gestational diabetes mellitus alters neonatal plasma lipids metabolism and causes hypercholesterolemia in the newborn period (47).…”

Section: Fetal Protein Metabolismmentioning

confidence: 99%

Maternal and Fetal Carbohydrate, Lipid and Protein Metabolisms

Şengül

Dede

2014

Electron J Gen Med

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Comparison of the effect of maternal hypothyroidism on carbohydrate metabolism in young and aged male offspring in rats

Cited by 25 publications

References 43 publications

Transient Congenital Hypothyroidism Alters Gene Expression of Glucose Transporters and Impairs Glucose Sensing Apparatus in Young and Aged Offspring Rats

Transient Congenital Hypothyroidism Alters Gene Expression of Glucose Transporters and Impairs Glucose Sensing Apparatus in Young and Aged Offspring Rats

Hemodynamic properties and arterial structure in male rat offspring with fetal hypothyroidism

Maternal and Fetal Carbohydrate, Lipid and Protein Metabolisms

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