Comparison of the effect of aerosolized fibrin sealant and biodegradable synthetic polyurethane foam on hemostasis and wound healing after endoscopic sinus surgery: a prospective randomized study

Abstract

FS and Nasopore were equally successful in achieving hemostasis and patient satisfaction after FESS. However, our results suggest that differential mucosal healing patterns may be induced by alternative absorbable hemostatic materials. FS-treated sides showed more optimal healing patterns than Nasopore-packed sides.

Fibrin tissue adhesive versus nasal packing in endoscopic nasal surgery: a systematic review and meta-analysis

“…The studies by Vaiman et al and Gleich et al presented data as binary outcomes (24,26) ; the studies by Jung et al and Yu et al used an ordinal scale (0 = absent to 3 = severe) to grade the severity of outcomes measured by clinicians, and a VAS (0 = no symptoms to 10 = unbearable) to grade the severity of outcomes measured by participants (12,25) . Since bleeding was assessed by both clinicians and participants in some studies, the method used is indicated in the table (12,25) .…”

“…The studies by Vaiman et al and Gleich et al presented data as binary outcomes (24,26) ; the studies by Jung et al and Yu et al used an ordinal scale (0 = absent to 3 = severe) to grade the severity of outcomes measured by clinicians, and a VAS (0 = no symptoms to 10 = unbearable) to grade the severity of outcomes measured by participants (12,25) . Since bleeding was assessed by both clinicians and participants in some studies, the method used is indicated in the table (12,25) . Additionally, where studies presented clinician-assessed outcome data on a range of follow these acting as 'split-participants' , meaning they received the intervention in one nasal cavity and the comparison in the other (12,24,25) .…”

“…Since bleeding was assessed by both clinicians and participants in some studies, the method used is indicated in the table (12,25) . Additionally, where studies presented clinician-assessed outcome data on a range of follow these acting as 'split-participants' , meaning they received the intervention in one nasal cavity and the comparison in the other (12,24,25) . All studies used FTA as the sole intervention with either Merocel (12,26) , Nasopore (25) , or Gelfoam as the comparison (24) .…”

“…Unfortunately, upon initial analysis it became apparent that one study did not include a denominator in the results (22) , and a second study was noted to have a significant overlap in participants after consultation with the author (23) . These studies were subsequently removed, and the remaining four studies underwent analysis (12,(24)(25)(26) .…”

The Effect of TISSEEL® on Colorectal Anastomosis Healing Process in a Diabetic Animal Experimental Model

“…Diabetes affects a large number of physiological factors involved in the healing process, such as growth factor production, angiogenic response, collagen concentration, tissue granulation and extracellular matrix accumulation and remodeling by matrix metalloproteinases (16). However, fibrin sealants have been used as hemostatic factors and enhancers of the wound healing process in various surgical procedures including gastrointestinal anastomoses, plastic surgery, gynecologic and urologic procedures (17,18).…”