Comparison of the Dose Accuracy of Prefilled Insulin Pens

Weise, Alexander; Pfützner, J; Borig, Julia; Pfützner, A; Safinowski, Michael; Hänel, Heike; Musholt, Petra B.; Pfützner, Andreas

doi:10.1177/193229680900300116

Cited by 20 publications

(21 citation statements)

References 12 publications

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“…9 Comparing the SR with the NGFP revealed good performance of both pens but reported few doses outside the ISO limits for both pens. 10 All the above- mentioned studies included only a small number of doses and pens. In terms of an overall assessment of the dosing accuracy we conducted the first comparable study on a large scale including the most common insulin pens, SR, FP, NGFP, and KP, covering the low (1 unit), the middle (30 and 40 units), and the high (60 units) dosage levels for all pens in addition to the 80-unit dosage level for the SR in line with ISO guidelines.…”

Section: Discussionmentioning

confidence: 99%

Study on the Dosing Accuracy of Commonly Used Disposable Insulin Pens

Krzywon

Burg

Fuhr

et al. 2012

Diabetes Technology & Therapeutics

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Background: Improved patient comfort and optimal glycemic control have led to the widespread use of insulin pens, particularly in Europe. Most of the former studies on the dose accuracy of insulin pens included only a small number of doses and pens. In extension to our previous large-scale study testing the dosing accuracy following a randomized dosing sequence with each pen, the present study was more directed toward the dose accuracy for one specific dose dispensed repeatedly with the same pen. This is the first study providing detailed comparative data on the accuracy of repeated dose delivery with prefilled disposable insulin pens at low, middle, and high doses, dispensed over the entire pen volume. Results: All tested insulin pens met the requirements for accuracy with none of the single values being outside the defined range of the ISO recommendations (1 -1 units, 30 -1.5 units, and 60 -3 units, respectively). Conclusion:The present study demonstrated a consistent and accurate dose delivery at all dosage levels for all tested insulin pens, with no clinically relevant differences among the products.

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Section: Discussionmentioning

confidence: 99%

Study on the Dosing Accuracy of Commonly Used Disposable Insulin Pens

Krzywon

Burg

Fuhr

et al. 2012

Diabetes Technology & Therapeutics

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“…53 Another study also found that SoloSTAR and the original FlexPen were similarly accurate when used by device-naive individuals to deliver 20-unit doses of insulin. 65 One study compared the improved FlexPen with SoloSTAR: both pens showed very good accuracy, and the improved FlexPen was even more accurate than the SoloSTAR (p < 0.05) 64 ( Table 2).…”

Section: Clinical Studies Comparing Insulin Pensmentioning

confidence: 99%

“…60 To avoid this, it may be necessary to carry out multiple priming before injecting with the OptiClik pen. Other studies have examined the dosing accuracy of SoloSTAR compared with FlexPen (improved and original), Humulin/Humalog pen, and OptiClik pen 59,[61][62][63][64] ( Table 2). The largest of these comparative studies investigated 2280 doses of the SoloSTAR and the original FlexPen devices and showed that pens had comparable accuracy over the standard doses of 5, 10, and 30 units.…”

Section: Clinical Studies Comparing Insulin Pensmentioning

confidence: 99%

Practical Aspects of Insulin Pen Devices

Pearson

2010

J Diabetes Sci Technol

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Insulin pen devices have several advantages over the traditional vial-and-syringe method of insulin delivery, including improved patient satisfaction and adherence, greater ease of use, superior accuracy for delivering small doses of insulin, greater social acceptability, and less reported injection pain. In recent years, pens have become increasingly user-friendly, and some models are highly intuitive to use, requiring little or no instruction. Despite this progress, uptake of these devices in the United States has not matched that in many other areas of the world. There is a need for improved awareness of the current characteristics of insulin pen devices among United States health care professionals. Knowledge of the design improvements that have been incorporated into pens, both to address patient needs and as a result of the improved technology behind the device mechanics, is essential to promoting the use of insulin pen devices. This review highlights some of the practical aspects of pen use and discusses the factors to be considered when selecting among different insulin pens.

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“…The image selected for the calculation was a coronal image including the caudate nucleus, putamen and thalamus, as images at this level also include the temporal lobe and frontal lobe, atrophy of which are especially related to cognitive impairment or dementia [21,22]. From day 3 of admission, the subjects were provided training sessions for insulin self-injection three or four times a day using the checklist shown in Table 1, which was made according to the instruction manual of NovoRapid ® FlexPen ® (Novo Nordisk, Bagsvaerd, Denmark) [23,24]. Training sessions were provided by nurses working in the field of diabetes under diabetologist's guidance and were standardized using the descriptive brochure provided by Novo Nordisk Pharma Ltd..…”

mentioning

confidence: 99%