Comparison of the deleterious effects of yaji and cadmium chloride on testicular physiomorphological and oxidative stress status: The gonadoprotective effects of an omega-3 fatty acid

Ekhoye, E. I.; Olerimi, Samson Eshikhokhale; Ehebha, Santos Ehizokhale

doi:10.5653/cerm.2019.03517

Cited by 4 publications

(5 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The testicular weight and the body weight of each rat were determined. The gonadosomatic index was reached by the formula: gonadosomatic index = the testicular weight /the body weight × 100% ( 17 ).…”

Section: Methodsmentioning

confidence: 99%

Chronic exposure to yttrium induced cell apoptosis in the testis by mediating Ca2+/IP3R1/CaMKII signaling

Liu

Ding

Xie

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

IntroductionEnvironmental pollutants, such as rare earth elements, affect human health and particularly induce reproductive system injury. Yttrium (Y), one of the most widely used heavy rare earth elements, has been reported the cytotoxicity. However, the biological effects of Y3+ in the human body are largely unknown.MethodsTo further investigate the effects of Y on the reproductive system, in vivo (rat models) and in vitro studies were performed. Histopathological and immunohistochemical examination were conducted, and western blotting assays were performed to detect the protein expression. TUNEL/DAPI staining were used to detect cell apoptosis, and the intracellular calcium concentrations were also determined.ResultsLong-term exposure to YCl3 in rats produced significant pathological changes. YCl3 treatment could induce cell apoptosis in vivo and in vitro. In addition, YCl3 enhanced the concentration of cytosolic Ca2+ and up regulated the expression of IP3R1/CaMKII axis in Leydig cells. However, inhibition of IP3R1 and CaMKII with 2-APB and KN93, respectively, could reverse these effects.ConclusionLong-term exposure to yttrium could induce testicular injury by stimulating cell apoptosis, which might be associated with activation of Ca2+/IP3R1/CaMKII axis in Leydig cells.

show abstract

Section: Methodsmentioning

confidence: 99%

Chronic exposure to yttrium induced cell apoptosis in the testis by mediating Ca2+/IP3R1/CaMKII signaling

Liu

Ding

Xie

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…Therefore, it is reasonable to believe that n-3 PUFAs have ameliorating effects on Cd exposure-induced reproductive impairment. Indeed, significant reductions in sperm count, sperm motility, and the percentage of sperm with normal morphology were studied in Cd exposure-induced mice, and supplementation with n-3 PUFAs could largely alleviate the effects of Cd on semen quality ( 154 ). Researchers in another study thought that this improvement might be mediated by the antioxidant properties of n-3 PUFAs ( 155 ).…”

Section: The Role Of N-3 Pufas In CD Exposurementioning

confidence: 99%

The function of omega-3 polyunsaturated fatty acids in response to cadmium exposure

Chen

Wang

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Throughout history, pollution has become a part of our daily life with the improvement of life quality and the advancement of industry and heavy industry. In recent years, the adverse effects of heavy metals, such as cadmium (Cd), on human health have been widely discussed, particularly on the immune system. Here, this review summarizes the available evidence on how Cd exposure may affect health. By analyzing the general manifestations of inflammation caused by Cd exposure, we find that the role of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) in vivo can counteract Cd-induced harm. Additionally, we elucidate the effects of n-3 PUFAs on the immune system, and analyze their prophylactic and therapeutic effects on Cd exposure. Overall, this review highlights the role of n-3 PUFAs in the pathological changes induced by Cd exposure. Although n-3 PUFAs remain to be verified whether they can be used as therapeutic agents, as rehabilitation therapy, supplementation with n-3 PUFAs is reliable and effective.

show abstract

“…Increased level of MDA suggests that CdCl 2 -induced oxidative stress causes testicular damage by increasing ROS production [ 194 ]. When 2.5 mg/kg body weight CdCl 2 was orally supplemented to two groups of male rats for 14 and 42 days, respectively, it caused a duration-dependent decrease in testosterone levels, FSH, and LH along with decreased semen quality parameters and gonadosomatic index [ 195 ]. Cadmium accumulation in testis generates high levels of ROS, subsequently surpassing the antioxidant capacity of testes.…”

Section: Environmental Factorsmentioning

confidence: 99%

“…Sperm and testicular Leydig cell mitochondria are highly susceptible to Cd-induced oxidative stress. Cadmium may cause spermatotoxicity by either affecting spermatogenesis via oxidative stress or disrupting the HPG axis [ 195 , 199 ].…”

Section: Environmental Factorsmentioning

confidence: 99%

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

et al. 2021

View full text Add to dashboard Cite

Hypogonadism is an endocrine disorder characterized by inadequate serum testosterone production by the Leydig cells of the testis. It is triggered by alterations in the hypothalamic–pituitary–gonadal axis. Erectile dysfunction (ED) is another common disorder in men that involves an alteration in erectile response–organic, relational, or psychological. The incidence of hypogonadism and ED is common in men aged over 40 years. Hypogonadism (including late-onset hypogonadism) and ED may be linked to several environmental factors-induced oxidative stresses. The factors mainly include exposure to pesticides, radiation, air pollution, heavy metals and other endocrine-disrupting chemicals. These environmental risk factors may induce oxidative stress and lead to hormonal dysfunctions. To better understand the subject, the study used many keywords, including “hypogonadism”, “late-onset hypogonadism”, “testosterone”, “erectile dysfunction”, “reactive oxygen species”, “oxidative stress”, and “environmental pollution” in major online databases, such as SCOPUS and PUBMED to extract relevant scientific information. Based on these parameters, this review summarizes a comprehensive insight into the important environmental issues that may have a direct or indirect association with hypogonadism and ED in men. The study concludes that environmental factors-induced oxidative stress may cause infertility in men. The hypothesis and outcomes were reviewed critically, and the mechanistic approaches are applied through oxidant-sensitive pathways. This study also provides reccomendations on future therapeutic interventions and protective measures against such adverse environmental factors-induced hypogonadism and ED.

show abstract

Comparison of the deleterious effects of yaji and cadmium chloride on testicular physiomorphological and oxidative stress status: The gonadoprotective effects of an omega-3 fatty acid

Cited by 4 publications

References 50 publications

Chronic exposure to yttrium induced cell apoptosis in the testis by mediating Ca2+/IP3R1/CaMKII signaling

Chronic exposure to yttrium induced cell apoptosis in the testis by mediating Ca2+/IP3R1/CaMKII signaling

The function of omega-3 polyunsaturated fatty acids in response to cadmium exposure

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

Contact Info

Product

Resources

About