Comparison of the Corneal Endothelium in an American and a Japanese Population

Matsuda, Michihiko; Yee, Richard W.; Edelhauser, Henry F.

doi:10.1001/archopht.1985.01050010072023

Cited by 116 publications

(105 citation statements)

References 16 publications

(2 reference statements)

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“…1 Geyer et al 2 found equal prevalence of glaucoma in OSAS as in the general population. Ophthalmic findings in OSAS are floppy eyelid syndrome, 3,4 keratoconus, 5 papilloedema, 6 and ischaemic optic neuropathy. 7 Optic nerve vascular dysregulation secondary to OSAS-induced arterial hypertension and arteriosclerosis or the imbalance between nitric oxide (a vasodilator) and endothelin (a vasoconstrictor) has been suggested to contribute to optic neuropathy.…”

Section: Case Reportmentioning

confidence: 42%

Corneal endothelial cell density in a normal Pakistani population

Ashraf

Saeed

Zia

2005

Eye

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Section: Case Reportmentioning

confidence: 42%

Corneal endothelial cell density in a normal Pakistani population

Ashraf

Saeed

Zia

2005

Eye

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“…There is also a racial difference in endothelial cell density, which, for example, is significantly higher in the Japanese than the Americans [3]. In Fuchs corneal endothelial dystrophy, cell density decreases more rapidly and more extensively which eventually results in bullous keratopathy.…”

Section: Introductionmentioning

confidence: 38%

Prevalence of Primary Cornea guttata and Morphology of Corneal Endothelium in Aging Japanese and Singaporean Subjects

et al. 2002

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The purpose of the present study was to examine, in the aging people, racial and gender differences in the morphology of corneal endothelium as well as the incidence of cornea guttata in two Asian subject groups, one in Singapore and the other in Japan. Four hundred and sixty-five Chinese Singaporeans and 299 Japanese subjects (residents of Monzen-machi, Ishikawa Prefecture) aged 50 years and older were recruited for the study. Corneal endothelial abnormalities were diagnosed with slit-lamp biomicroscopy and specular microscopy. Primary cornea guttata appeared as beaten metal appearance in slit-lamp images and dark regions in specular images. In addition to cornea guttata, corneal endothelial morphology was also analysed with specular microscopy. The mean cell density was 2,808/mm² in the Japanese subjects which was significantly higher than the 2,718/mm² seen in the Singaporeans (p < 0.001). The incidence of cornea guttata was significantly higher in the Singaporeans than in the Japanese individuals and also higher in women than in men of both racial groups. These differences support not only a racial and a gender factor but also a possible environmental influence.

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“…The cell density for Asian subject is greater at all age ranges than the Caucasion race. The data points (diamonds) are from a Japanese patient group (linear line, Y=4109-124X) and the data (triangles) are from an Caucasian American patient group (linear line, Y=3254-121X) 18 . Mean endothelial cell density values for ICCE patients (Inable eta 1985 32 ) are plotted in Graph A to demonstrate regional endothelial cell changes after superior incision ICCE.…”

Section: Guidelines For Specular Microscopy In Fda Clinical Trialsmentioning

confidence: 49%

Review of Corneal Endothelial Specular Microscopy for FDA Clinical Trials of Refractive Procedures, Surgical Devices, and New Intraocular Drugs and Solutions

McCarey¹,

Edelhauser²,

Lynn³

2008

Cornea

292

235

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Specular microscopy can provide a non-invasive morphological analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiological reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corneal endothelium. The purpose of this review is to discuss normal and stressed endothelial cell morphology, the techniques for determining the morphology parameters, and clinical trial applications.

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Comparison of the Corneal Endothelium in an American and a Japanese Population

Cited by 116 publications

References 16 publications

Corneal endothelial cell density in a normal Pakistani population

Corneal endothelial cell density in a normal Pakistani population

Prevalence of Primary Cornea guttata and Morphology of Corneal Endothelium in Aging Japanese and Singaporean Subjects

Review of Corneal Endothelial Specular Microscopy for FDA Clinical Trials of Refractive Procedures, Surgical Devices, and New Intraocular Drugs and Solutions

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