Comparison of the Clinical Implications among Five Different Nutritional Indices in Patients with Lupus Nephritis

Ahn, Sung Soo; Yoo, Juyoung; Jung, Seung Min; Song, Jason Jungsik; Park, Yong Bum; Lee, Sang Won

doi:10.3390/nu11071456

Cited by 20 publications

(22 citation statements)

References 48 publications

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“…Older age might be associated with more complications, which increased the mortality rate. In one study, predictors related to 30-day mortality included older, non-healthcare workers, pre-existing conditions, disease severity, and hospital-acquired infections [31].Interestingly, BMI was originally considered only as a way to measure body composition, but now obesity is considered a chronic inflammatory state that may affect the immune system through fat-derived inflammation [32]. COVID-19 was currently considered to have potential complex immunological damage [30].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Clinical Implications among Two Different Nutritional Indices in Hospitalized Patients with COVID-19

Liu

Chen

et al. 2020

Preprint

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Background: Coronavirus disease 2019 is an emerging infectious disease.It was first reported in Wuhan, China, and then broke out on a large scale around the world.This study aimed to assess the clinical significance of two different nutritional indices in 245 patients with COVID-19. Methods:In this retrospective single-center study, we finally included 245 consecutive patients who confirmed COVID-19 in Wuhan University Zhongnan Hospital from January 1 to February 29. Cases were classified as either discharged or dead. Demographic, clinical and laboratory datas were registered, two different nutritional indices were calculated: (i)the Controlling nutritional status (CONUT) score;(ii) prognostic nutritional index (PNI). We used univariate and multivariate logistic regression analysis to explore the relationship between nutritional indices and hospital death .Results: 212 of them were discharged and 33 of them died. In-hospital mortality was signifcantly higher in the severe group of PNI than in the moderate and normal groups. It was also significantly worse in the severe-CONUT group than in the moderate-, mild-, and normal-CONUT groups.Multivariate logistic regression analysis showed the CONUT score (odds ratio3.371,95%CI(1.124-10.106), p = 0.030) and PNI(odds ratio 0.721,95% CI(0.581-0.896),P=0.003) were independent predictors of all-cause death at an early stage; Multivariate logistic regression analysis also showed that the severe group of PNI was the independent risk predictor of in-hospital death(odds ratio 24.225, 95% CI (2.147-273.327) , p=0.010).The CONUT score cutoff value was 5.5 (56.00 and 80.81%; AUC 0.753; 95% CI (0.644-0.862) ;respectively).The PNI cutoff value was 40.58 (81.80 and 66.20%; AUC 0.778; 95% CI(0.686-0.809); respectively).We use PNI and the COUNT score to assess malnutrition, which can have a prognosis effect of COVID-19patients. Conclusion:The CONUT score and PNI could be a reliable prognostic marker of all-cause deathin patients with COVID-19. (933-5129) <0·001 PCT,ng/ml 0.0(0.00-0.11) 0 (0.00-0.07) 0 (0.00-0.03) 0.06 (0.00-0.23) 0.43 (0.1-1.16) <0·001 All-cause death 25(16.13%) 1(5.6%) 6(8.3%) 12(20.69%) 6(85.71%) <0·001 COPD, chronic obstructive pulmonary disease; WBC, white blood cells; ALT, alanine aminotransferase;TC,Total cholesterol; HDL, high density lipoprotein PT, prothrombin time;PCT,Procalcitonin; CONUT, Controlling nutritional status; PNI, Prognostic nutritional index; BMI, Body mass index *Between evaluation of clinical indicators and COUNT score, 90 patients lacked records of lymphocyte counts or albumin or total cholesterolModel 1 :The multivariate analysis of PNI associated with in-hospital death adjusted for age, sex, BMI, history of hypertension, history of chronic obstructive pulmonary disease ， history of coronary heart disease ,respiratory rate, alanine transaminase, creatinine, D-dimer, white blood cell count, Lymphocyte, PCT, Model 2 :The multivariate analysis of COUNT score associated with in-hospital death adjusted for age, sex, BMI, history of hypertension, h...

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Section: Discussionmentioning

confidence: 99%

Comparison of the Clinical Implications among Two Different Nutritional Indices in Hospitalized Patients with COVID-19

Liu

Chen

et al. 2020

Preprint

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“…Its utility has been demonstrated in the assessment of the prognosis of patients with end-stage liver disease and acute heart failure [16,17]; it has also been correlated with the disease activity in patients with lupus nephritis [27]. The impact of CONUT score on survival has also been reported in hospitalized elderly people [28] and in patients with hypertension [18] or in peritoneal dialysis [19].…”

Section: Introductionmentioning

confidence: 99%

CONUT Score: A New Tool for Predicting Prognosis in Patients with Advanced Thyroid Cancer Treated with TKI

Dalmiglio

Brilli

Campanile

et al. 2022

Cancers

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(1) Background: The Controlling Nutritional Status (CONUT) score is an immuno-nutritional screening tool based on serum albumin, total cholesterol, and lymphocyte count. The aim of the study was to assess the CONUT score as a potential prognostic factor of response to therapy in patients with advanced thyroid cancer treated with tyrosine kinase inhibitors (TKIs). (2) Methods: We retrospectively evaluated 42 metastatic thyroid cancer patients (54.8% female). The median age at the time of TKI treatment was 69 years. Histological diagnosis was differentiated thyroid cancer in 66.7%, poorly differentiated thyroid cancer in 21.4%, and medullary thyroid cancer in 11.9% of patients. CONUT score was assessed before starting TKI therapy. (3) Results: Progression-free survival (PFS) and overall survival (OS) were significantly influenced by baseline CONUT score. The best CONUT cut-off able to predict the response to treatment was 3. Both PFS and OS were better in patients with CONUT score <3 than in those with CONUT score ≥3 (p < 0.0001). CONUT score was the only independent prognostic factor associated with PFS (p = 0.021) and OS (p = 0.007). (4) Conclusions: CONUT score represents a relatively new screening tool, easily applicable in clinical practice and potentially useful in predicting prognosis in thyroid cancer patients treated with TKIs.

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“…The CONUT score is now used as an immuno-nutritional index [16,17]. It correlates with disease activity in patients with lupus nephritis [18]. The CONUT score is also associated with poor survival in patients with hepatitis B virus reactivation [19].…”

Section: Introductionmentioning

confidence: 99%

Controlling Nutritional Status (CONUT) Score is Associated with Overall Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Cohort Study

et al. 2020

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We aimed to investigate the impact of the controlling nutritional status (CONUT) score, an immuno-nutritional biomarker, on the prognosis of patients with hepatocellular carcinoma (HCC) treated with lenvatinib (LEN). This retrospective study enrolled 164 patients with HCC and treated with LEN (median age 73 years, Barcelona Clinic Liver Cancer (BCLC) stage B/C 93/71). Factors associated with overall survival (OS) were evaluated using multivariate and decision tree analyses. OS was calculated using the Kaplan–Meier method and analyzed using the log–rank test. Independent factors for OS were albumin–bilirubin grade 1, BCLC stage B, and CONUT score <5 (hazard ratio (HR) 2.9, 95% confidence interval (CI) 1.58–5.31, p < 0.001). The CONUT score was the most important variable for OS, with OS rates of 70.0% and 29.0% in the low and high CONUT groups, respectively. Additionally, the median survival time was longer in the low CONUT group than in the high CONUT group (median survival time not reached vs. 11.3 months, p < 0.001). The CONUT score was the most important prognostic variable, rather than albumin–bilirubin grade and BCLC stage, in patients with HCC treated with LEN. Accordingly, immuno-nutritional status may be an important factor in the management of patients with HCC treated with LEN.

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Comparison of the Clinical Implications among Five Different Nutritional Indices in Patients with Lupus Nephritis

Cited by 20 publications

References 48 publications

Comparison of the Clinical Implications among Two Different Nutritional Indices in Hospitalized Patients with COVID-19

Comparison of the Clinical Implications among Two Different Nutritional Indices in Hospitalized Patients with COVID-19

CONUT Score: A New Tool for Predicting Prognosis in Patients with Advanced Thyroid Cancer Treated with TKI

Controlling Nutritional Status (CONUT) Score is Associated with Overall Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Cohort Study

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