CONUT Score: A New Tool for Predicting Prognosis in Patients with Advanced Thyroid Cancer Treated with TKI

Dalmiglio, Cristina; Brilli, Lucia; Campanile, M; Ciuoli, Cristina; Cartocci, Alessandra; Castagna, Maria Grazia

doi:10.3390/cancers14030724

Cited by 15 publications

(8 citation statements)

References 51 publications

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“…Finally, CONUT consists of lymphocytes and albumin together with cholesterol, so it is not difficult to understand that CONUT is associated with the prognosis of cancer patients. The coefficient of CONUT in NMRS was 0.354, which is consistent with previous findings ( 52 ).…”

Section: Discussionsupporting

confidence: 92%

A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma

et al. 2022

Front. Nutr.

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Osteosarcoma is a primary malignant bone tumor with high metastatic potential. To date, achieving long-term survival of osteosarcoma patients remains a difficult task. Metabolic reprogramming has emerged as a new hallmark of cancer. However, studies on the prognostic value of hematological markers related to nutritional and metabolism in cancer patients are limited and contradictory. In this retrospective study, we extensively collected 16 hematological markers related to nutritional and metabolism in 223 osteosarcoma patients. A nutritional metabolism related prognostic scoring system (NMRS) in patients with osteosarcoma was constructed by least absolute contraction and selection operator (LASSO) cox regression analysis. Compared with individual hematological indicators, NMRS has stronger predictive power (training set: 0.811 vs. 0.362–2.638; validation set: 0.767 vs. 0.333–0.595). It is an independent prognostic factor for the survival of patients with osteosarcoma [HR: 1.957 (1.375–2.786) training set; HR: 3.146 (1.574–6.266) validation set]. NMRS-based nomograms have good and stable predictive power. NMRS facilitates further risk stratification of patients with the same clinical characteristics.

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Section: Discussionsupporting

confidence: 92%

A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma

et al. 2022

Front. Nutr.

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“…The CONUT score is an index related to ALB concentration, lymphocyte count, and TC concentration. Studies have shown that the CONUT score is strongly correlated with the survival rate of patients with thyroid cancer; it is also an independent risk factor for lung cancer prognosis[ 25 , 43 ]. NPS is an index related to serum ALB concentration, TC concentration, LMR, and NLR and has been proven to be a predictor of OS in a variety of tumors.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of preoperative immune-nutritional scoring systems in remnant gastric cancer patients undergoing surgery

Zhang¹,

Wang²,

Li³

et al. 2023

World J Gastrointest Surg

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BACKGROUND Remnant gastric cancer (GC) is defined as GC that occurs five years or more after gastrectomy. Systematically evaluating the preoperative immune and nutritional status of patients and analyzing its prognostic impact on postoperative remnant gastric cancer (RGC) patients are crucial. A simple scoring system that combines multiple immune or nutritional indicators to identify nutritional or immune status before surgery is necessary. AIM To evaluate the value of preoperative immune-nutritional scoring systems in predicting the prognosis of patients with RGC. METHODS The clinical data of 54 patients with RGC were collected and analyzed retrospectively. Prognostic nutritional index (PNI), controlled nutritional status (CONUT), and Naples prognostic score (NPS) were calculated by preoperative blood indicators, including absolute lymphocyte count, lymphocyte to monocyte ratio, neutrophil to lymphocyte ratio, serum albumin, and serum total cholesterol. Patients with RGC were divided into groups according to the immune-nutritional risk. The relationship between the three preoperative immune-nutritional scores and clinical characteristics was analyzed. Cox regression and Kaplan–Meier analysis was performed to analyze the difference in overall survival (OS) rate between various immune-nutritional score groups. RESULTS The median age of this cohort was 70.5 years (ranging from 39 to 87 years). No significant correlation was found between most pathological features and immune-nutritional status ( P > 0.05). Patients with a PNI score < 45, CONUT score or NPS score ≥ 3 were considered to be at high immune-nutritional risk. The areas under the receiver operating characteristic curves of PNI, CONUT, and NPS systems for predicting postoperative survival were 0.611 [95% confidence interval (CI): 0.460–0.763; P = 0.161], 0.635 (95%CI: 0.485–0.784; P = 0.090), and 0.707 (95%CI: 0.566–0.848; P = 0.009), respectively. Cox regression analysis showed that the three immune-nutritional scoring systems were significantly correlated with OS (PNI: P = 0.002; CONUT: P = 0.039; NPS: P < 0.001). Survival analysis revealed a significant difference in OS between different immune-nutritional groups (PNI: 75 mo vs 42 mo, P = 0.001; CONUT: 69 mo vs 48 mo, P = 0.033; NPS: 77 mo vs 40 mo, P < 0.001). CONCLUSION These preoperative immune-nutritional scores are reliable multidimensional prognostic scoring systems for predicting the prognosis of patients with RGC, in which the NPS system has relatively effective predictive performance.

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“…Results indicated that CONUT score is a prognostic item in patients with MDS. Although the underline mechanism of action and how high CONUT score indicates true undernutrition or cachexia are still unclear, but it becomes a consensus that CONUT score is a useful tool ( 19 – 21 ), which can be quickly and accurately detected in peripheral blood test at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of the controlling nutritional status score in patients with myelodysplastic syndromes

Chen

Wang

et al. 2022

Front. Nutr.

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BackgroundMyelodysplastic syndromes (MDS) are a heterogeneous spectrum of clonal hematopoietic disorders with varying degrees of cytopenia and morphologic dysplasia. The controlling nutritional status (CONUT) score, an easy-to-use tool for assessing the nutritional status, was reported as an independent prognostic factor in cancer patients. However, its role in patients with MDS is unclear.ObjectiveWe aimed to explore the impact of CONUT score on the prognosis of patients with MDS, which is of great significance for clinical treatment.MethodsA total of 121 patients with MDS were analyzed. The CONUT score was calculated prior to therapy. The bio-informatics tool X-tile was used to define the CONUT score and the threshold of 4 points was determined to predict the prognosis. Patients were divided into CONUTlow and CONUThigh groups, and the characteristics were compared between two groups.ResultsResults show that CONUTlow was associated with better overall survival (OS) than CONUThigh patients (Median OS, 30.20 vs. 19.63 months, p = 0.0003). However, there were no statistical differences in progression-free survival (PFS) between the two groups (p = 0.2683). Results of univariate and multivariate COX proportional hazard analysis adjusted for bone marrow blasts level, platelet count, International Prognostic Scoring System (IPSS) scores, gender, and hemoglobin (Hb) level showed that the CONUT score was useful in the evaluation standard of OS of MDS (hazard ratio (HR) 2.297, 95% CI 1.441–3.663, p < 0.001).ConclusionsThe CONUT, as a novel immuno-nutritional biomarker, may be useful in predicting the OS of MDS.

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CONUT Score: A New Tool for Predicting Prognosis in Patients with Advanced Thyroid Cancer Treated with TKI

Cited by 15 publications

References 51 publications

A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma

A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma

Prognostic value of preoperative immune-nutritional scoring systems in remnant gastric cancer patients undergoing surgery

Prognostic value of the controlling nutritional status score in patients with myelodysplastic syndromes

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