Comparison of the Anti-angiogenic and Anti-inflammatory Effects of Two Antibiotics: Clarithromycin Versus Moxifloxacin

Uehara, Hironori; Das, Subrata K.; Cho, Yang Kyung; Archer, Bonnie; Ambati, Balamurali K.

doi:10.3109/02713683.2015.1037926

Cited by 6 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moxifloxacin is a fourth-generation QN that has a strong antibacterial activity in Gram-positive and Gram-negative bacteria, and thus has wide clinical uses. In recent years, a number of studies have demonstrated the immunomodulatory effects of MXF ( 49 – 52 ). Anti-infection therapies should not only consider the sensitivity and potency of antibacterial agents; however, the association between antibacterial in vivo efficacy and immunoregulation additionally requires consideration.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages

Qiu

Yuan

et al. 2018

Mol Med Report

View full text Add to dashboard Cite

Sepsis is a systemic inflammatory condition in response to life-threatening infections, and macrophages are a key source of inflammatory cytokines. Moxifloxacin (MXF) has antibacterial activity in Gram-positive and Gram-negative bacteria. The present study investigated the effects of MXF on a lipopolysaccharide (LPS)-stimulated inflammatory response and gene expression in macrophages. Peritoneal macrophages were isolated from male C57BL/6J mice and treated with LPS and/or MXF. The mRNA and protein expression of toll-like receptor 4 (TLR4), sphingosine kinase 1 (SPHK1) and nuclear factor (NF)-κB was determined by quantitative polymerase chain reaction, western blotting and immunofluorescence analysis. The expression of tumor necrosis factor (TNF)-α and interleukin (IL)-6 was determined with ELISAs. The data demonstrated that MXF dose-dependently decreased the viability of macrophages, and 8 and 16 µg/ml MXF prevented the LPS-induced increase in TLR4, SPHK1, NF-κB p65, TNF-α and IL-6 expression. The inhibition was most effective at a concentration of 16 µg/ml MXF, whereas, 64 µg/ml MXF exerted a pro-inflammatory effect. Collectively, the data demonstrated a bidirectional effect of MXF: Lower MXF concentrations (8 and 16 µg/ml) inhibited the inflammatory response; however, a higher MXF concentration (64 µg/ml) had a pro-inflammatory effect on LPS-treated mouse peritoneal macrophages. In conclusion, these results suggested the importance of MXF as an inhibitor of the inflammatory response at an optimal dose. MXF inhibition of the inflammatory response may be mediated by TLR4 signaling.

show abstract

Section: Discussionmentioning

confidence: 99%

Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages

Qiu

Yuan

et al. 2018

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…It has also been documented that AZM can inhibit epithelial-to-mesenchymal transition (EMT) in lung epithelium (Banerjee et al, 2012;Pu et al, 2018), further supporting its role as an epithelial barrier-protecting drug. Macrolides are also able to inhibit the release by fibroblasts of vascular endothelial growth factor, and this may contribute to inhibitory effects of clarithromycin on angiogenesis during chronic inflammation (Yatsunami and Hayashi, 2001;Kanoh and Rubin, 2010;Uehara et al, 2016).…”

Section: A Anti-inflammatory/immunomodulatory Effectsmentioning

confidence: 99%

Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development

et al. 2021

View full text Add to dashboard Cite

“…Conservative therapeutic approaches aim to control causative factors, to alleviate pain and to restore a stable ocular surface in the early stage of LSCD, including nonpreserved lubricating eye drops, autologous serum drops, bandage contact lenses, anti-inflammatory drugs, and anti-angiogenic therapy [ 173 , 174 , 175 , 176 , 177 ]. Autologous serum eye drops as a natural preservative-free and growth factor-containing lubricant can promote corneal epithelial healing and medically reverse advanced LSCD [ 178 , 179 ].…”

Section: Therapy Of Lscdmentioning

confidence: 99%

Corneal Epithelial Stem Cells–Physiology, Pathophysiology and Therapeutic Options

Ruan

Jiang

Musayeva

et al. 2021

Cells

View full text Add to dashboard Cite

In the human cornea, regeneration of the epithelium is regulated by the stem cell reservoir of the limbus, which is the marginal region of the cornea representing the anatomical and functional border between the corneal and conjunctival epithelium. In support of this concept, extensive limbal damage, e.g., by chemical or thermal injury, inflammation, or surgery, may induce limbal stem cell deficiency (LSCD) leading to vascularization and opacification of the cornea and eventually vision loss. These acquired forms of limbal stem cell deficiency may occur uni- or bilaterally, which is important for the choice of treatment. Moreover, a variety of inherited diseases, such as congenital aniridia or dyskeratosis congenita, are characterized by LSCD typically occurring bilaterally. Several techniques of autologous and allogenic stem cell transplantation have been established. The limbus can be restored by transplantation of whole limbal grafts, small limbal biopsies or by ex vivo-expanded limbal cells. In this review, the physiology of the corneal epithelium, the pathophysiology of LSCD, and the therapeutic options will be presented.

show abstract

Comparison of the Anti-angiogenic and Anti-inflammatory Effects of Two Antibiotics: Clarithromycin Versus Moxifloxacin

Abstract: Clarithromycin suppressed LY and inflammation in the cornea, and its anti-inflammatory effect was significantly superior to that of moxifloxacin.

Cited by 6 publications

References 31 publications

Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages

Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages

Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development

Corneal Epithelial Stem Cells–Physiology, Pathophysiology and Therapeutic Options

Contact Info

Product

Resources

About