Comparison of the Anesthetic Efficacy of Mepivacaine and Lidocaine in Patients with Irreversible Pulpitis: A Double-blind Randomized Clinical Trial

Visconti, Renata Pieroni; Tortamano, Isabel Peixoto; Buscariolo, Inês Aparecida

doi:10.1016/j.joen.2016.06.015

Cited by 29 publications

(57 citation statements)

References 29 publications

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“…, Visconti et al . ). Two of the six articles were excluded – one (Allegretti ) for being previously published as an eligible article and another (Maniglia‐Ferreira et al .…”

Section: Resultsmentioning

confidence: 97%

“…, Visconti et al . ) compared mepivacaine 2% and lidocaine 2%, both with a vasoconstrictor, whilst one study (Cohen et al . ) compared mepivacaine 3% without vasoconstrictor and lidocaine 2% with vasoconstrictor.…”

Section: Resultsmentioning

confidence: 99%

“…, Visconti et al . ) applied an electric pulp test 10 min after the IAN block. Initially, the IAN block was considered successful if a negative response was observed after maximum stimulation (80 mA).…”

Section: Resultsmentioning

confidence: 99%

“…, Visconti et al . ) that classified pain in none (0), slight (1), moderate (2) and severe (3). Scores 0 and 1 indicated pain levels that did not hamper the treatment.…”

Section: Resultsmentioning

confidence: 99%

“…, Visconti et al . ). There is an even greater uncertainty considering the limited scientific literature on the efficacy of mepivacaine compared to other drugs (Claffey et al .…”

Section: Introductionmentioning

confidence: 97%

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Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta‐analysis

et al. 2018

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This study aimed to compare the effectiveness of mepivacaine and lidocaine for pulpal anaesthesia and pain control when administered via an inferior alveolar nerve block during the root canal treatment of mandibular molars in patients with symptomatic irreversible pulpitis. A research protocol was developed and registered in PROSPERO. The systematic search was conducted during May 2017 in eight databases. The studies were selected based on inclusion and exclusion criteria. Two examiners analysed the sample independently, decided the eligibility for inclusion and classified the articles according to their quality. Statistical analysis was performed with MantelHaenszel and I-square (I 2 ) tests considering a confidence interval of 95%. The initial sample consisted of 1130 articles, out of which four were eligible. The articles were published between 1993 and 2016. For both pulpal anaesthesia and pain control, there was no significant difference between mepivacaine and lidocaine (P = 0.843, I 2 = 0%, and P = 0.183, I 2 = 21.1%, respectively). Mepivacaine and lidocaine were similarly effective for pulpal anaesthesia and pain control after inferior alveolar nerve blocks for root canal treatment.

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“…, Visconti et al . ). Two of the six articles were excluded – one (Allegretti ) for being previously published as an eligible article and another (Maniglia‐Ferreira et al .…”

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…, Visconti et al . ) that classified pain in none (0), slight (1), moderate (2) and severe (3). Scores 0 and 1 indicated pain levels that did not hamper the treatment.…”

Section: Resultsmentioning

confidence: 99%

“…, Visconti et al . ). There is an even greater uncertainty considering the limited scientific literature on the efficacy of mepivacaine compared to other drugs (Claffey et al .…”

Section: Introductionmentioning

confidence: 97%

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Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta‐analysis

et al. 2018

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Injectable local anaesthetic agents for dental anaesthesia

George

Morgan

Meechan

et al. 2018

Cochrane Database of Systematic Reviews

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For success (absence of pain), low-quality evidence suggests that 4% articaine, 1:100,000 epinephrine was superior to 2% lidocaine, 1:100,000 epinephrine for root treating of posterior teeth with irreversible pulpitis, and 2% lidocaine, 1:100,000 epinephrine was superior to 4% prilocaine plain when surgical procedures/periodontal treatment was provided. Moderate-quality evidence shows that 2% lidocaine, 1:100,000 epinephrine was superior to 3% prilocaine, 0.03 IU felypressin when surgical procedures were performed.Adverse events were rare. Moderate-quality evidence shows no difference in pain on injection when 4% articaine, 1:100,000 epinephrine and 2% lidocaine, 1:100,000 epinephrine were compared, although lidocaine resulted in slightly less pain following injection.Many outcomes tested our primary objectives in simulated scenarios, although clinical alternatives may not be possible.Further studies are needed to increase the strength of the evidence. These studies should be clearly reported, have low risk of bias with adequate sample size, and provide data in a format that will allow meta-analysis. Once assessed, results of the 34 'Studies awaiting classification (full text unavailable)' may alter the conclusions of the review.

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Basic Injection Technique

2024

Local Anesthesia in Dentistry

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Comparison of the Anesthetic Efficacy of Mepivacaine and Lidocaine in Patients with Irreversible Pulpitis: A Double-blind Randomized Clinical Trial

Cited by 29 publications

References 29 publications

Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta‐analysis

Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta‐analysis

Injectable local anaesthetic agents for dental anaesthesia

Basic Injection Technique

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