Comparison of the anesthetic efficacy and cardiopulmonary effects of continuous rate infusions of alfaxalone-2-hydroxypropyl-β-cyclodextrin and propofol in dogs

Alfaxalone and medetomidine intravenous infusion to maintain anaesthesia in colts undergoing field castration

“…There is currently limited information regarding the cardiovascular effects of alfaxalone in the horse. In the dog, a 2 h infusion of alfaxalone resulted in only mild haemodynamic changes with cardiac variables (cardiac index, heart rate, systemic vascular resistance, arterial blood pressure) remaining stable and not differing significantly from baseline values [29]. In conscious ponies sedated with an i.v.…”

The cardiopulmonary effects and quality of anesthesia after induction with alfaxalone in 2‐hydroxypropyl‐β‐cyclodextrin in dogs and cats: a systematic review

“…Two of the studies (Maddern et al, 2010;Michou et al, 2012) in dogs and one study in cats were rated an LOE1; ROB1. There were a total of six LOE1 studies (Maddern et al, 2010;Psatha et al, 2011;Michou et al, 2012;Suarez et al, 2012;Amengual et al, 2013;, four LOE3 studies (Ambros et al, 2008;Muir et al, 2008;Rodriguez et al, 2012;Maney et al, 2013), and one LOE5 study (O'Hagan et al, 2012a,b) in dogs on this subject. One LOE1 study , one LOE3 study (Muir et al, 2009), and one LOE5 study (O'Hagan et al, 2012a,b) included information on this topic in cats.…”

“…One study in dogs (Jimenez et al, 2012) and one study in cats were graded an LOE1, ROB1. For dogs, there were a total of six LOE1 studies (Maddern et al, 2010;Psatha et al, 2011;Suarez et al, 2012;Amengual et al, 2013;Bortolami et al, 2013;Hunt et al, 2013), five LOE3 studies (Ambros et al, 2008;Muir et al, 2008;Keates & Whittem, 2012;Rodriguez et al, 2012;Maney et al, 2013), and one LOE5 study (O'Hagan et al, 2012a,b) on the quality of recovery from anesthesia. For cats, there were two LOE1 studies Mathis et al, 2012), one LOE2 study (Zaki et al, 2009), two LOE3 studies Muir et al, 2009) and one LOE5 study (O'Hagan et al, 2012a,b) on this topic.…”

“…Several categories of bias were identified in the studies included in this review. Many of the studies were not blinded, which increases the risk of detection bias (Ambros et al, 2008;O'Hagan et al, 2012a,b;Suarez et al, 2012;. Some studies had selection bias due to nonrandom allocation of subjects into treatment groups (Ambros et al, 2008;Zaki et al, 2009).…”

“…Many of the studies were not blinded, which increases the risk of detection bias (Ambros et al, 2008;O'Hagan et al, 2012a,b;Suarez et al, 2012;. Some studies had selection bias due to nonrandom allocation of subjects into treatment groups (Ambros et al, 2008;Zaki et al, 2009). Psatha et al (2011) had missing data 20 min postinduction, which may risk attrition bias (Psatha et al, 2011).…”